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• W2890291036 abstract "Obesity increases the risk of numerous chronic diseases. Obesity is classified clinically using body mass index (BMI), waist-to-hip ratio, and body fat percentage. The lipoprotein lipase (LPL) gene has been linked to lipoprotein metabolism and obesity. We performed a case-control study to determine the association between LPL gene polymorphisms and obesity-associated phenotypes such as insulin resistance (IR).We examined the different LPL gene variants for association in 642 individuals segregated by BMI and IR. Genotyping of the LPL gene -93 and -53 promoter gene polymorphisms were analyzed using polymerase chain reaction-restriction fragment length polymorphism.A substantial association was observed for -93 gene polymorphism of the LPL gene with obesity, while -53 promoter gene polymorphism showed association with IR.We found a significant association between -93 and -53 promoter gene polymorphisms of the LPL gene with obesity and associated phenotypes in the studied population." @default.
• W2890291036 created "2018-09-27" @default.
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• W2890291036 date "2018-09-10" @default.
• W2890291036 modified "2023-10-10" @default.
• W2890291036 title "The Association of a Rare Variant of -93, -53 Promoter Gene Polymorphisms of Lipoprotein Lipase Gene with Obesity and Insulin Resistance" @default.
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• W2890291036 doi "https://doi.org/10.5001/omj.2018.74" @default.
• W2890291036 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6131921" @default.
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