FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2890300209> ?p ?o ?g. }

• W2890300209 endingPage "102" @default.
• W2890300209 startingPage "97" @default.
• W2890300209 abstract "Oxidative deamination of norepinephrine (NE) and dopamine (DA) by monoamine oxidase (MAO) generates the catecholaldehydes 3,4-dihydroxyphenylglycolaldehyde (DOPEGAL) and 3,4-dihydroxyphenylacetaldehyde (DOPAL), respectively, and H2O2. Catecholaldehydes are highly reactive electrophiles that have been implicated as causal factors in the etiology of neurodegenerative diseases and cardiac injury from ischemia and diabetes. The reactivity of both catechol and aldehyde groups enables the catecholaldehdyes to cross-link proteins and other biological molecules. Carnosine is a β-alanyl-histidine dipeptide found in millimolar concentrations in brain and myocardium. It is well known to detoxify aldehydes formed from oxidized lipids and sugars, yet the reactivity of carnosine with catecholaldehydes has never been reported. Here, we investigated the ability of carnosine to form conjugates with DOPAL and DOPEGAL. Both catecholaldehydes were highly reactive towards l-cysteine (l-Cys), as well as carnosine; however, glutathione (GSH) showed essentially no reactivity towards DOPAL. In contrast, GSH readily reacted with the lipid peroxidation product 4-hydroxy-2-nonenal (4HNE), while carnosine showed low reactivity to 4HNE by comparison. To determine whether carnosine mitigates catecholaldehyde toxicity, samples of atrial myocardium were collected from patients undergoing elective cardiac surgery. Using permeabilized myofibers prepared from this tissue, mitochondrial respiration analysis revealed a concentration-dependent decrease in ADP-stimulated respiration with DOPAL. Pre-incubation with carnosine, but not GSH or l-Cys, significantly reduced this effect (p < 0.05). Carnosine was also able to block formation of catecholaldehyde protein adducts in isolated human cardiac mitochondria treated with NE. These findings demonstrate the unique reactivity of carnosine towards catecholaldehydes and, therefore, suggest a novel and distinct biological role for histidine dipeptides in this detoxification reaction. The therapeutic potential of carnosine in diseases associated with catecholamine-related toxicity is worthy of further examination." @default.
• W2890300209 created "2018-09-27" @default.
• W2890300209 creator A5016208056 @default.
• W2890300209 creator A5017984161 @default.
• W2890300209 creator A5040748951 @default.
• W2890300209 creator A5050028150 @default.
• W2890300209 creator A5090081860 @default.
• W2890300209 date "2018-09-06" @default.
• W2890300209 modified "2023-09-26" @default.
• W2890300209 title "Biochemical characterization of the catecholaldehyde reactivity of l-carnosine and its therapeutic potential in human myocardium" @default.
• W2890300209 cites W103420449 @default.
• W2890300209 cites W1544469036 @default.
• W2890300209 cites W1964832419 @default.
• W2890300209 cites W1965138638 @default.
• W2890300209 cites W1972381933 @default.
• W2890300209 cites W1980234111 @default.
• W2890300209 cites W1988131381 @default.
• W2890300209 cites W1994043090 @default.
• W2890300209 cites W1996805139 @default.
• W2890300209 cites W2007271767 @default.
• W2890300209 cites W2010947186 @default.
• W2890300209 cites W2015827383 @default.
• W2890300209 cites W2015970562 @default.
• W2890300209 cites W2016756266 @default.
• W2890300209 cites W2043969745 @default.
• W2890300209 cites W2066019537 @default.
• W2890300209 cites W2070703124 @default.
• W2890300209 cites W2071627769 @default.
• W2890300209 cites W2073508576 @default.
• W2890300209 cites W2077261489 @default.
• W2890300209 cites W2080689158 @default.
• W2890300209 cites W2084538987 @default.
• W2890300209 cites W2101239107 @default.
• W2890300209 cites W2111370164 @default.
• W2890300209 cites W2118389697 @default.
• W2890300209 cites W2138121094 @default.
• W2890300209 cites W2141410612 @default.
• W2890300209 cites W2164853857 @default.
• W2890300209 cites W2172121372 @default.
• W2890300209 cites W2282981307 @default.
• W2890300209 cites W2409170833 @default.
• W2890300209 cites W2747997044 @default.
• W2890300209 doi "https://doi.org/10.1007/s00726-018-2647-y" @default.
• W2890300209 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6924506" @default.
• W2890300209 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30191330" @default.
• W2890300209 hasPublicationYear "2018" @default.
• W2890300209 type Work @default.
• W2890300209 sameAs 2890300209 @default.
• W2890300209 citedByCount "19" @default.
• W2890300209 countsByYear W28903002092019 @default.
• W2890300209 countsByYear W28903002092020 @default.
• W2890300209 countsByYear W28903002092021 @default.
• W2890300209 countsByYear W28903002092022 @default.
• W2890300209 countsByYear W28903002092023 @default.
• W2890300209 crossrefType "journal-article" @default.
• W2890300209 hasAuthorship W2890300209A5016208056 @default.
• W2890300209 hasAuthorship W2890300209A5017984161 @default.
• W2890300209 hasAuthorship W2890300209A5040748951 @default.
• W2890300209 hasAuthorship W2890300209A5050028150 @default.
• W2890300209 hasAuthorship W2890300209A5090081860 @default.
• W2890300209 hasBestOaLocation W28903002092 @default.
• W2890300209 hasConcept C181199279 @default.
• W2890300209 hasConcept C185592680 @default.
• W2890300209 hasConcept C2776024655 @default.
• W2890300209 hasConcept C2776151105 @default.
• W2890300209 hasConcept C2780687331 @default.
• W2890300209 hasConcept C2780829032 @default.
• W2890300209 hasConcept C538909803 @default.
• W2890300209 hasConcept C55493867 @default.
• W2890300209 hasConceptScore W2890300209C181199279 @default.
• W2890300209 hasConceptScore W2890300209C185592680 @default.
• W2890300209 hasConceptScore W2890300209C2776024655 @default.
• W2890300209 hasConceptScore W2890300209C2776151105 @default.
• W2890300209 hasConceptScore W2890300209C2780687331 @default.
• W2890300209 hasConceptScore W2890300209C2780829032 @default.
• W2890300209 hasConceptScore W2890300209C538909803 @default.
• W2890300209 hasConceptScore W2890300209C55493867 @default.
• W2890300209 hasFunder F4320337337 @default.
• W2890300209 hasFunder F4320337338 @default.
• W2890300209 hasIssue "1" @default.
• W2890300209 hasLocation W28903002091 @default.
• W2890300209 hasLocation W28903002092 @default.
• W2890300209 hasLocation W28903002093 @default.
• W2890300209 hasLocation W28903002094 @default.
• W2890300209 hasOpenAccess W2890300209 @default.
• W2890300209 hasPrimaryLocation W28903002091 @default.
• W2890300209 hasRelatedWork W1989354585 @default.
• W2890300209 hasRelatedWork W2015274231 @default.
• W2890300209 hasRelatedWork W2031629077 @default.
• W2890300209 hasRelatedWork W2040577258 @default.
• W2890300209 hasRelatedWork W2042958718 @default.
• W2890300209 hasRelatedWork W2070656560 @default.
• W2890300209 hasRelatedWork W2083726789 @default.
• W2890300209 hasRelatedWork W2332315579 @default.
• W2890300209 hasRelatedWork W2415187581 @default.
• W2890300209 hasRelatedWork W2472379420 @default.
• W2890300209 hasVolume "51" @default.
• W2890300209 isParatext "false" @default.

• next