FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2890301436> ?p ?o ?g. }

• W2890301436 endingPage "4226" @default.
• W2890301436 startingPage "4211" @default.
• W2890301436 abstract "20,230 protein-coding genes have been predicted from the analysis of the human genome (neXtProt release 2018-01-17), and about 10% of them are still lacking functional annotation, either predicted by bioinformatics tools or captured from experimental reports. A systematic exploration of the available literature on uncharacterized human genes/proteins led to proposal of functional annotations for 113 proteins and to consolidation of a list of 1,862 uncharacterized human proteins. The advanced search functionality of neXtProt was used extensively in order to examine the landscape of the uncharacterized human proteome in terms of subcellular locations, protein–protein interactions, tissue expression, association with diseases, and 3D structure. Finally, a deep data mining in various publicly available resources allowed building functional hypotheses for 26 uncharacterized human proteins validated at protein level (uPE1). These hypotheses cover the fields of cilia biology, male reproduction, metabolism, nervous system, immunity, inflammation, RNA metabolism, and chromatin biology. They will require experimental validation before they can be considered for annotation. Despite technological progresses, the pace of human protein characterization studies is still slow. It could be accelerated by a better integration of existing knowledge resources and by initiating large collaborative projects involving specialists of different biology fields. We hope that our analysis will contribute to set up the ground for such collaborative approaches and will be exploited by the HUPO Human Proteome Project teams committed to characterize uPE1 proteins." @default.
• W2890301436 created "2018-09-27" @default.
• W2890301436 creator A5041748189 @default.
• W2890301436 creator A5068838014 @default.
• W2890301436 creator A5069843378 @default.
• W2890301436 creator A5077746658 @default.
• W2890301436 date "2018-09-07" @default.
• W2890301436 modified "2023-10-13" @default.
• W2890301436 title "Exploring the Uncharacterized Human Proteome Using neXtProt" @default.
• W2890301436 cites W1425381042 @default.
• W2890301436 cites W1513793790 @default.
• W2890301436 cites W1530075337 @default.
• W2890301436 cites W1925671842 @default.
• W2890301436 cites W1965033845 @default.
• W2890301436 cites W1971192989 @default.
• W2890301436 cites W1975046858 @default.
• W2890301436 cites W1976672042 @default.
• W2890301436 cites W1978047973 @default.
• W2890301436 cites W1978326437 @default.
• W2890301436 cites W1979817764 @default.
• W2890301436 cites W1983127887 @default.
• W2890301436 cites W1989277387 @default.
• W2890301436 cites W1992008514 @default.
• W2890301436 cites W1994803330 @default.
• W2890301436 cites W2001130890 @default.
• W2890301436 cites W2010651323 @default.
• W2890301436 cites W2012034410 @default.
• W2890301436 cites W2013218791 @default.
• W2890301436 cites W2018075425 @default.
• W2890301436 cites W2018838463 @default.
• W2890301436 cites W2020558917 @default.
• W2890301436 cites W2031145877 @default.
• W2890301436 cites W2036032819 @default.
• W2890301436 cites W2042826490 @default.
• W2890301436 cites W2053218283 @default.
• W2890301436 cites W2054839912 @default.
• W2890301436 cites W2056041927 @default.
• W2890301436 cites W2060769471 @default.
• W2890301436 cites W2068496730 @default.
• W2890301436 cites W2068871850 @default.
• W2890301436 cites W2069860553 @default.
• W2890301436 cites W2070387100 @default.
• W2890301436 cites W2079898750 @default.
• W2890301436 cites W2081375228 @default.
• W2890301436 cites W2084858500 @default.
• W2890301436 cites W2087072206 @default.
• W2890301436 cites W2089417149 @default.
• W2890301436 cites W2091264505 @default.
• W2890301436 cites W2098650870 @default.
• W2890301436 cites W2099477841 @default.
• W2890301436 cites W2100557679 @default.
• W2890301436 cites W2101553897 @default.
• W2890301436 cites W2103017472 @default.
• W2890301436 cites W2108797218 @default.
• W2890301436 cites W2110256992 @default.
• W2890301436 cites W2117397620 @default.
• W2890301436 cites W2126194787 @default.
• W2890301436 cites W2130479394 @default.
• W2890301436 cites W2138779444 @default.
• W2890301436 cites W2141154711 @default.
• W2890301436 cites W2144392328 @default.
• W2890301436 cites W2144542560 @default.
• W2890301436 cites W2145378936 @default.
• W2890301436 cites W2145825345 @default.
• W2890301436 cites W2146526204 @default.
• W2890301436 cites W2147871639 @default.
• W2890301436 cites W2148670907 @default.
• W2890301436 cites W2151671698 @default.
• W2890301436 cites W2155575747 @default.
• W2890301436 cites W2159841286 @default.
• W2890301436 cites W2165329833 @default.
• W2890301436 cites W2166977115 @default.
• W2890301436 cites W2170329239 @default.
• W2890301436 cites W2197381113 @default.
• W2890301436 cites W2219197181 @default.
• W2890301436 cites W2258035417 @default.
• W2890301436 cites W2288308260 @default.
• W2890301436 cites W2293873588 @default.
• W2890301436 cites W2306300251 @default.
• W2890301436 cites W2323678851 @default.
• W2890301436 cites W2363363069 @default.
• W2890301436 cites W2399912172 @default.
• W2890301436 cites W2437130027 @default.
• W2890301436 cites W2470951287 @default.
• W2890301436 cites W2471350098 @default.
• W2890301436 cites W2472696785 @default.
• W2890301436 cites W2488048472 @default.
• W2890301436 cites W2498027120 @default.
• W2890301436 cites W2518901523 @default.
• W2890301436 cites W2520711929 @default.
• W2890301436 cites W2520816666 @default.
• W2890301436 cites W2549998959 @default.
• W2890301436 cites W2557496587 @default.
• W2890301436 cites W2559861862 @default.
• W2890301436 cites W2560310361 @default.
• W2890301436 cites W257459350 @default.
• W2890301436 cites W2586245344 @default.
• W2890301436 cites W2609827283 @default.

• next