FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2890306495> ?p ?o ?g. }

• W2890306495 endingPage "6186" @default.
• W2890306495 startingPage "6178" @default.
• W2890306495 abstract "BACKGROUND:Osteosarcoma is the most common primary bone malignancy and often presents at an early age. Calycosin is a phytoestrogen isoflavone, which has previously been reported to inhibit tumor cell growth. The aim of this study was to investigate the effects of calycosin on apoptosis of estrogen receptor (ER)-positive and ER-negative human osteosarcoma cell lines and tumor xenografts in mice. MATERIAL AND METHODS:Cultured ER-positive MG-63 human osteosarcoma cells and ER-negative U2-OS human osteosarcoma cells were treated with increasing doses of calycosin (0, 25, 50, and 100 μm). Cell viability and apoptosis were studied by an MTT assay and flow cytometry. Western blot measured the expression levels of the apoptosis-related protein p-PI3K, p-Akt, and p-mTOR in MG-63 cells, with and without pretreatment with the PI3K inhibitor, LY294002, the AKT inhibitor, MK-2206, or the mTOR inhibitor, rapamycin. MG-63 tumor-bearing nude mice were used to evaluate the effects of treatment with calycosin. RESULTS:Calycosin treatment inhibited proliferation and induced apoptosis in MG-63 cells, but had no effect on U2-0S cells. In MG-63 cells, calycosin treatment increased the expression of the PI3K/AKT/mTOR pathway proteins; inhibitor assays showed that expression of the PI3K protein was most strongly associated with the antitumor effects of calycosin. In the nude mouse MG-63 tumor xenografts, calycosin inhibited tumor growth and regulated the expression levels of apoptosis-related PI3K/AKT/mTOR pathway proteins. CONCLUSIONS:The phytoestrogen, calycosin, induced apoptosis of cells of the ER-positive osteosarcoma cell line, MG-63, via the PI3K/AKT/mTOR pathway, with these effects being mainly due to PI3K." @default.
• W2890306495 created "2018-09-27" @default.
• W2890306495 creator A5012429052 @default.
• W2890306495 creator A5017077218 @default.
• W2890306495 creator A5038576892 @default.
• W2890306495 creator A5090839187 @default.
• W2890306495 date "2018-09-05" @default.
• W2890306495 modified "2023-09-26" @default.
• W2890306495 title "Calycosin, a Phytoestrogen Isoflavone, Induces Apoptosis of Estrogen Receptor-Positive MG-63 Osteosarcoma Cells via the Phosphatidylinositol 3-Kinase (PI3K)/AKT/Mammalian Target of Rapamycin (mTOR) Pathway" @default.
• W2890306495 cites W1611610664 @default.
• W2890306495 cites W181426613 @default.
• W2890306495 cites W1836802760 @default.
• W2890306495 cites W1961187943 @default.
• W2890306495 cites W1966483713 @default.
• W2890306495 cites W1977943009 @default.
• W2890306495 cites W1989920462 @default.
• W2890306495 cites W2030132546 @default.
• W2890306495 cites W2039026538 @default.
• W2890306495 cites W2043310375 @default.
• W2890306495 cites W2053496951 @default.
• W2890306495 cites W2074433596 @default.
• W2890306495 cites W2087877138 @default.
• W2890306495 cites W2088459820 @default.
• W2890306495 cites W2100983960 @default.
• W2890306495 cites W2104014368 @default.
• W2890306495 cites W2117247812 @default.
• W2890306495 cites W2178308549 @default.
• W2890306495 cites W2472847134 @default.
• W2890306495 cites W2556240288 @default.
• W2890306495 cites W2556502410 @default.
• W2890306495 doi "https://doi.org/10.12659/msm.910201" @default.
• W2890306495 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6134888" @default.
• W2890306495 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30182951" @default.
• W2890306495 hasPublicationYear "2018" @default.
• W2890306495 type Work @default.
• W2890306495 sameAs 2890306495 @default.
• W2890306495 citedByCount "16" @default.
• W2890306495 countsByYear W28903064952019 @default.
• W2890306495 countsByYear W28903064952020 @default.
• W2890306495 countsByYear W28903064952021 @default.
• W2890306495 countsByYear W28903064952022 @default.
• W2890306495 countsByYear W28903064952023 @default.
• W2890306495 crossrefType "journal-article" @default.
• W2890306495 hasAuthorship W2890306495A5012429052 @default.
• W2890306495 hasAuthorship W2890306495A5017077218 @default.
• W2890306495 hasAuthorship W2890306495A5038576892 @default.
• W2890306495 hasAuthorship W2890306495A5090839187 @default.
• W2890306495 hasBestOaLocation W28903064952 @default.
• W2890306495 hasConcept C121608353 @default.
• W2890306495 hasConcept C134018914 @default.
• W2890306495 hasConcept C153911025 @default.
• W2890306495 hasConcept C185592680 @default.
• W2890306495 hasConcept C190283241 @default.
• W2890306495 hasConcept C2776578907 @default.
• W2890306495 hasConcept C2777760704 @default.
• W2890306495 hasConcept C2778298627 @default.
• W2890306495 hasConcept C2779580426 @default.
• W2890306495 hasConcept C2780783641 @default.
• W2890306495 hasConcept C2780955279 @default.
• W2890306495 hasConcept C502942594 @default.
• W2890306495 hasConcept C530470458 @default.
• W2890306495 hasConcept C53227056 @default.
• W2890306495 hasConcept C54355233 @default.
• W2890306495 hasConcept C55493867 @default.
• W2890306495 hasConcept C62112901 @default.
• W2890306495 hasConcept C75217442 @default.
• W2890306495 hasConcept C84606932 @default.
• W2890306495 hasConcept C86554907 @default.
• W2890306495 hasConcept C86803240 @default.
• W2890306495 hasConceptScore W2890306495C121608353 @default.
• W2890306495 hasConceptScore W2890306495C134018914 @default.
• W2890306495 hasConceptScore W2890306495C153911025 @default.
• W2890306495 hasConceptScore W2890306495C185592680 @default.
• W2890306495 hasConceptScore W2890306495C190283241 @default.
• W2890306495 hasConceptScore W2890306495C2776578907 @default.
• W2890306495 hasConceptScore W2890306495C2777760704 @default.
• W2890306495 hasConceptScore W2890306495C2778298627 @default.
• W2890306495 hasConceptScore W2890306495C2779580426 @default.
• W2890306495 hasConceptScore W2890306495C2780783641 @default.
• W2890306495 hasConceptScore W2890306495C2780955279 @default.
• W2890306495 hasConceptScore W2890306495C502942594 @default.
• W2890306495 hasConceptScore W2890306495C530470458 @default.
• W2890306495 hasConceptScore W2890306495C53227056 @default.
• W2890306495 hasConceptScore W2890306495C54355233 @default.
• W2890306495 hasConceptScore W2890306495C55493867 @default.
• W2890306495 hasConceptScore W2890306495C62112901 @default.
• W2890306495 hasConceptScore W2890306495C75217442 @default.
• W2890306495 hasConceptScore W2890306495C84606932 @default.
• W2890306495 hasConceptScore W2890306495C86554907 @default.
• W2890306495 hasConceptScore W2890306495C86803240 @default.
• W2890306495 hasLocation W28903064951 @default.
• W2890306495 hasLocation W28903064952 @default.
• W2890306495 hasLocation W28903064953 @default.
• W2890306495 hasLocation W28903064954 @default.
• W2890306495 hasOpenAccess W2890306495 @default.
• W2890306495 hasPrimaryLocation W28903064951 @default.
• W2890306495 hasRelatedWork W2384173773 @default.
• W2890306495 hasRelatedWork W2385169010 @default.

• next