FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2890314188> ?p ?o ?g. }

• W2890314188 endingPage "560" @default.
• W2890314188 startingPage "547" @default.
• W2890314188 abstract "Despite the essential role of the active metabolite of vitamin A, all-trans retinoic acid (atRA) in spermatogenesis, the enzymes, and cellular populations responsible for its synthesis in the postnatal testis remain largely unknown. The aldehyde dehydrogenase 1A (ALDH1A) family of enzymes residing within Sertoli cells is responsible for the synthesis of atRA, driving the first round of spermatogenesis. Those studies also revealed that the atRA required to drive subsequent rounds of spermatogenesis is possibly derived from the ALDH1A enzymes residing within the meiotic and post-meiotic germ cells. Three ALDH1A isozymes (ALDH1A1, ALDH1A2, and ALDH1A3) are present in the testis. Although, ALDH1A1 is expressed in adult Sertoli cells and is suggested to contribute to the atRA required for the pre-meiotic transitions, ALDH1A2 is proposed to be the essential isomer involved in testicular atRA biosynthesis. In this report, we first examine the requirement for ALDH1A2 via the generation and analysis of a conditional Aldh1a2 germ cell knockout and a tamoxifen-induced Aldh1a2 knockout model. We then utilized the pan-ALDH1A inhibitor (WIN 18446) to test the collective contribution of the ALDH1A enzymes to atRA biosynthesis following the first round of spermatogenesis. Collectively, our data provide the first in vivo evidence demonstrating that animals severely deficient in ALDH1A2 postnatally proceed normally through spermatogenesis. Our studies with a pan-ALDH1A inhibitor (WIN 18446) also suggest that an alternative source of atRA biosynthesis independent of the ALDH1A enzymes becomes available to maintain atRA levels for several spermatogenic cycles following an initial atRA injection." @default.
• W2890314188 created "2018-09-27" @default.
• W2890314188 creator A5007577863 @default.
• W2890314188 creator A5013587307 @default.
• W2890314188 creator A5026603966 @default.
• W2890314188 creator A5036416416 @default.
• W2890314188 creator A5036636635 @default.
• W2890314188 creator A5055101259 @default.
• W2890314188 creator A5072175880 @default.
• W2890314188 date "2018-09-21" @default.
• W2890314188 modified "2023-10-07" @default.
• W2890314188 title "Sources of<i>all-trans</i>retinal oxidation independent of the aldehyde dehydrogenase 1A isozymes exist in the postnatal testis†" @default.
• W2890314188 cites W131928997 @default.
• W2890314188 cites W1495595158 @default.
• W2890314188 cites W1527331090 @default.
• W2890314188 cites W1590180359 @default.
• W2890314188 cites W160335167 @default.
• W2890314188 cites W1607516925 @default.
• W2890314188 cites W1618929865 @default.
• W2890314188 cites W1723001059 @default.
• W2890314188 cites W1911871301 @default.
• W2890314188 cites W1965809313 @default.
• W2890314188 cites W1972776993 @default.
• W2890314188 cites W1974267020 @default.
• W2890314188 cites W1977825177 @default.
• W2890314188 cites W1984912286 @default.
• W2890314188 cites W1987529504 @default.
• W2890314188 cites W1988092962 @default.
• W2890314188 cites W1990514940 @default.
• W2890314188 cites W1998194192 @default.
• W2890314188 cites W2002998074 @default.
• W2890314188 cites W2004293136 @default.
• W2890314188 cites W2007538507 @default.
• W2890314188 cites W2012565034 @default.
• W2890314188 cites W2014398701 @default.
• W2890314188 cites W2020121361 @default.
• W2890314188 cites W2021047790 @default.
• W2890314188 cites W2026130605 @default.
• W2890314188 cites W2029658854 @default.
• W2890314188 cites W2038639188 @default.
• W2890314188 cites W2040046771 @default.
• W2890314188 cites W2040213004 @default.
• W2890314188 cites W2046275054 @default.
• W2890314188 cites W2063144779 @default.
• W2890314188 cites W2067767286 @default.
• W2890314188 cites W2069084546 @default.
• W2890314188 cites W2073738799 @default.
• W2890314188 cites W2080524329 @default.
• W2890314188 cites W2082262367 @default.
• W2890314188 cites W2086345206 @default.
• W2890314188 cites W2093814700 @default.
• W2890314188 cites W2100309864 @default.
• W2890314188 cites W2107277218 @default.
• W2890314188 cites W2109887989 @default.
• W2890314188 cites W2110280340 @default.
• W2890314188 cites W2111104494 @default.
• W2890314188 cites W2115147225 @default.
• W2890314188 cites W2118001999 @default.
• W2890314188 cites W2119168427 @default.
• W2890314188 cites W2119742360 @default.
• W2890314188 cites W2120069727 @default.
• W2890314188 cites W2124090668 @default.
• W2890314188 cites W2125429880 @default.
• W2890314188 cites W2136456223 @default.
• W2890314188 cites W2141234587 @default.
• W2890314188 cites W2149940976 @default.
• W2890314188 cites W2150494778 @default.
• W2890314188 cites W2153935329 @default.
• W2890314188 cites W2155121802 @default.
• W2890314188 cites W2156326281 @default.
• W2890314188 cites W2164428202 @default.
• W2890314188 cites W2166187009 @default.
• W2890314188 cites W2168207691 @default.
• W2890314188 cites W2169148057 @default.
• W2890314188 cites W2171612928 @default.
• W2890314188 cites W2172205775 @default.
• W2890314188 cites W2192080449 @default.
• W2890314188 cites W2227045291 @default.
• W2890314188 cites W2237266875 @default.
• W2890314188 cites W2298207820 @default.
• W2890314188 cites W2327834369 @default.
• W2890314188 cites W2331948128 @default.
• W2890314188 cites W2413413428 @default.
• W2890314188 cites W2509148942 @default.
• W2890314188 cites W2533419568 @default.
• W2890314188 cites W2608706515 @default.
• W2890314188 cites W2767205153 @default.
• W2890314188 cites W2794070776 @default.
• W2890314188 doi "https://doi.org/10.1093/biolre/ioy200" @default.
• W2890314188 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6378859" @default.
• W2890314188 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30247516" @default.
• W2890314188 hasPublicationYear "2018" @default.
• W2890314188 type Work @default.
• W2890314188 sameAs 2890314188 @default.
• W2890314188 citedByCount "15" @default.
• W2890314188 countsByYear W28903141882018 @default.
• W2890314188 countsByYear W28903141882019 @default.
• W2890314188 countsByYear W28903141882020 @default.

• next