FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2890314577> ?p ?o ?g. }

• W2890314577 endingPage "e1510277" @default.
• W2890314577 startingPage "e1510277" @default.
• W2890314577 abstract "GBM tissues are comprised of not only tumor cells but also tumor-associated nontumor cells, such as stromal cells and immune cells, which dilute the purity of glioma cells and function in glioma biology. However, the roles of miRNAs in modulating glioma purity are not clarified. In total, 838 glioma samples with transcriptome data, including 537 RNAseq data from TCGA project and 301 microarray data from Chinese Glioma Genome Atlas (CGGA project), were recruited into our investigation. Tumor purity, molecular subtypes and IDH status were also available. R language was employed as the main tool for statistical analysis and graphical work. Screening miRNA profiling and paired TCGA samples' transcriptome data demonstrates that miR-17-5p expression harbors the most significant positive correlation with glioma purity among all miRNAs. CXCL14 shows robust negative correlation with miR-17-5p expression in TCGA and CGGA dataset. miR-17-5p directly targets CXCL14 and functions as a tumor-suppressor of GBM. CXCL14 showed lower expression in proneural subtype and may contribute as a potential marker for proneural subtype in glioma. Genes markedly correlated with CXCL14 are involved in essential functions associated with anti-tumor immune process. CXCL14 has a strong correlation with immune(T cells, Monocytic lineage and Neutrophils) and Fibroblasts within glioma environment. miR-17-5p and CXCL14 exhibited predictive values for high-grade glioma(HGG) patients: Higher miR-17-5p indicated significantly longer survival while lower CXCL14 indicated longer survival. Our results highlight the importance of the miR-17-5p-CXCL14 axis in regulating key steps of anti-tumor immune process and may serve as potential targets of immune treatments for gliomas." @default.
• W2890314577 created "2018-09-27" @default.
• W2890314577 creator A5004419270 @default.
• W2890314577 creator A5005168346 @default.
• W2890314577 creator A5007510730 @default.
• W2890314577 creator A5026037575 @default.
• W2890314577 creator A5030048278 @default.
• W2890314577 creator A5045399954 @default.
• W2890314577 creator A5065408488 @default.
• W2890314577 creator A5081675173 @default.
• W2890314577 date "2018-09-11" @default.
• W2890314577 modified "2023-10-17" @default.
• W2890314577 title "miR-17-5p-CXCL14 axis related transcriptome profile and clinical outcome in diffuse gliomas" @default.
• W2890314577 cites W1121277736 @default.
• W2890314577 cites W1649213427 @default.
• W2890314577 cites W1757089901 @default.
• W2890314577 cites W1809740262 @default.
• W2890314577 cites W1948215485 @default.
• W2890314577 cites W1973759139 @default.
• W2890314577 cites W1983798380 @default.
• W2890314577 cites W1996436013 @default.
• W2890314577 cites W2019889666 @default.
• W2890314577 cites W2024672608 @default.
• W2890314577 cites W2030384822 @default.
• W2890314577 cites W2049820772 @default.
• W2890314577 cites W2053122486 @default.
• W2890314577 cites W2056918364 @default.
• W2890314577 cites W2066671159 @default.
• W2890314577 cites W2085642771 @default.
• W2890314577 cites W2113942802 @default.
• W2890314577 cites W2130430382 @default.
• W2890314577 cites W2135404870 @default.
• W2890314577 cites W2140641560 @default.
• W2890314577 cites W2150544967 @default.
• W2890314577 cites W2156323704 @default.
• W2890314577 cites W2165261531 @default.
• W2890314577 cites W2172431577 @default.
• W2890314577 cites W2191192181 @default.
• W2890314577 cites W2220215167 @default.
• W2890314577 cites W2312281573 @default.
• W2890314577 cites W2415253563 @default.
• W2890314577 cites W2477394350 @default.
• W2890314577 cites W2533508881 @default.
• W2890314577 cites W2572346489 @default.
• W2890314577 cites W2590408006 @default.
• W2890314577 cites W2614733071 @default.
• W2890314577 cites W2617691667 @default.
• W2890314577 cites W2739998491 @default.
• W2890314577 cites W2765415318 @default.
• W2890314577 cites W2790573862 @default.
• W2890314577 cites W2797556919 @default.
• W2890314577 cites W2800458993 @default.
• W2890314577 doi "https://doi.org/10.1080/2162402x.2018.1510277" @default.
• W2890314577 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6279316" @default.
• W2890314577 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30524906" @default.
• W2890314577 hasPublicationYear "2018" @default.
• W2890314577 type Work @default.
• W2890314577 sameAs 2890314577 @default.
• W2890314577 citedByCount "17" @default.
• W2890314577 countsByYear W28903145772019 @default.
• W2890314577 countsByYear W28903145772020 @default.
• W2890314577 countsByYear W28903145772021 @default.
• W2890314577 countsByYear W28903145772022 @default.
• W2890314577 countsByYear W28903145772023 @default.
• W2890314577 crossrefType "journal-article" @default.
• W2890314577 hasAuthorship W2890314577A5004419270 @default.
• W2890314577 hasAuthorship W2890314577A5005168346 @default.
• W2890314577 hasAuthorship W2890314577A5007510730 @default.
• W2890314577 hasAuthorship W2890314577A5026037575 @default.
• W2890314577 hasAuthorship W2890314577A5030048278 @default.
• W2890314577 hasAuthorship W2890314577A5045399954 @default.
• W2890314577 hasAuthorship W2890314577A5065408488 @default.
• W2890314577 hasAuthorship W2890314577A5081675173 @default.
• W2890314577 hasBestOaLocation W28903145771 @default.
• W2890314577 hasConcept C104317684 @default.
• W2890314577 hasConcept C126322002 @default.
• W2890314577 hasConcept C12823836 @default.
• W2890314577 hasConcept C13373296 @default.
• W2890314577 hasConcept C150194340 @default.
• W2890314577 hasConcept C162317418 @default.
• W2890314577 hasConcept C2776194525 @default.
• W2890314577 hasConcept C2776914184 @default.
• W2890314577 hasConcept C2778227246 @default.
• W2890314577 hasConcept C45240729 @default.
• W2890314577 hasConcept C502942594 @default.
• W2890314577 hasConcept C54355233 @default.
• W2890314577 hasConcept C71924100 @default.
• W2890314577 hasConcept C86803240 @default.
• W2890314577 hasConceptScore W2890314577C104317684 @default.
• W2890314577 hasConceptScore W2890314577C126322002 @default.
• W2890314577 hasConceptScore W2890314577C12823836 @default.
• W2890314577 hasConceptScore W2890314577C13373296 @default.
• W2890314577 hasConceptScore W2890314577C150194340 @default.
• W2890314577 hasConceptScore W2890314577C162317418 @default.
• W2890314577 hasConceptScore W2890314577C2776194525 @default.
• W2890314577 hasConceptScore W2890314577C2776914184 @default.
• W2890314577 hasConceptScore W2890314577C2778227246 @default.
• W2890314577 hasConceptScore W2890314577C45240729 @default.

• next