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- W2890317593 abstract "Background & aims This review examines to what extent high-protein diets (HPD), which may favor body weight loss and improve metabolic outcomes in overweight and obese individuals, may also impact the gut environment, shaping the microbiota and the host-microbe (co)metabolic pathways and products, possibly affecting large intestine mucosa homeostasis. Methods PubMed-referenced publications were analyzed with an emphasis on dietary intervention studies involving human volunteers in order to clarify the beneficial vs. deleterious effects of HPD in terms of both metabolic and gut-related health parameters; taking into account the interactions with the gut microbiota. Results HPD generally decrease body weight and improve blood metabolic parameters, but also modify the fecal and urinary contents in various bacterial metabolites and co-metabolites. The effects of HPD on the intestinal microbiota composition appear rather heterogeneous depending on the type of dietary intervention. Recently, HPD consumption was shown to modify the expression of genes playing key roles in homeostatic processes in the rectal mucosa, without evidence of intestinal inflammation. Importantly, the effects of HPD on the gut were dependent on the protein source (i.e. from plant or animal sources), a result which should be considered for further investigations. Conclusion Although HPD appear to be efficient for weight loss, the effects of HPD on microbiota-derived metabolites and gene expression in the gut raise new questions on the impact of HPD on the large intestine mucosa homeostasis leading the authors to recommend some caution regarding the utilization of HPD, notably in a recurrent and/or long-term ways." @default.
- W2890317593 created "2018-09-27" @default.
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- W2890317593 date "2019-06-01" @default.
- W2890317593 modified "2023-10-11" @default.
- W2890317593 title "High-protein diets for weight management: Interactions with the intestinal microbiota and consequences for gut health. A position paper by the my new gut study group" @default.
- W2890317593 cites W1562652370 @default.
- W2890317593 cites W1665140791 @default.
- W2890317593 cites W1839306363 @default.
- W2890317593 cites W1879953056 @default.
- W2890317593 cites W1893271439 @default.
- W2890317593 cites W1898733506 @default.
- W2890317593 cites W1918701009 @default.
- W2890317593 cites W1934624334 @default.
- W2890317593 cites W1968105193 @default.
- W2890317593 cites W1977785247 @default.
- W2890317593 cites W1981461721 @default.
- W2890317593 cites W1985491729 @default.
- W2890317593 cites W1994800928 @default.
- W2890317593 cites W2005187828 @default.
- W2890317593 cites W2006719040 @default.
- W2890317593 cites W2012260947 @default.
- W2890317593 cites W2017410917 @default.
- W2890317593 cites W2020443042 @default.
- W2890317593 cites W2025210455 @default.
- W2890317593 cites W2025681379 @default.
- W2890317593 cites W2025707255 @default.
- W2890317593 cites W2026658658 @default.
- W2890317593 cites W2027962027 @default.
- W2890317593 cites W2030380421 @default.
- W2890317593 cites W2031355202 @default.
- W2890317593 cites W2032157852 @default.
- W2890317593 cites W2033051660 @default.
- W2890317593 cites W2033239478 @default.
- W2890317593 cites W2039563786 @default.
- W2890317593 cites W2040501063 @default.
- W2890317593 cites W2042394891 @default.
- W2890317593 cites W2050669021 @default.
- W2890317593 cites W2055219298 @default.
- W2890317593 cites W2056743479 @default.
- W2890317593 cites W2057083693 @default.
- W2890317593 cites W2060918076 @default.
- W2890317593 cites W2062661305 @default.
- W2890317593 cites W2063634345 @default.
- W2890317593 cites W2065925831 @default.
- W2890317593 cites W2066805219 @default.
- W2890317593 cites W2068368322 @default.
- W2890317593 cites W2074079138 @default.
- W2890317593 cites W2075041541 @default.
- W2890317593 cites W2075787169 @default.
- W2890317593 cites W2078770291 @default.
- W2890317593 cites W2082846038 @default.
- W2890317593 cites W2083022081 @default.
- W2890317593 cites W2083501377 @default.
- W2890317593 cites W2090742607 @default.
- W2890317593 cites W2092725930 @default.
- W2890317593 cites W2101238009 @default.
- W2890317593 cites W2104975759 @default.
- W2890317593 cites W2106273653 @default.
- W2890317593 cites W2107022700 @default.
- W2890317593 cites W2107334879 @default.
- W2890317593 cites W2107616906 @default.
- W2890317593 cites W2109241894 @default.
- W2890317593 cites W2116846792 @default.
- W2890317593 cites W2121331954 @default.
- W2890317593 cites W2124719566 @default.
- W2890317593 cites W2129314930 @default.
- W2890317593 cites W2129873036 @default.
- W2890317593 cites W2131902769 @default.
- W2890317593 cites W2134042092 @default.
- W2890317593 cites W2143789605 @default.
- W2890317593 cites W2144038971 @default.
- W2890317593 cites W2144776996 @default.
- W2890317593 cites W2145635845 @default.
- W2890317593 cites W2145860316 @default.
- W2890317593 cites W2147862619 @default.
- W2890317593 cites W2155897723 @default.
- W2890317593 cites W2157489298 @default.
- W2890317593 cites W2158773181 @default.
- W2890317593 cites W2159352552 @default.
- W2890317593 cites W2164791001 @default.
- W2890317593 cites W2166562121 @default.