Matches in SemOpenAlex for { <https://semopenalex.org/work/W2890318181> ?p ?o ?g. }
- W2890318181 abstract "ABSTRACT In humans and livestock, Clostridium perfringens is an important cause of intestinal infections that manifest as enteritis, enterocolitis, or enterotoxemia. This virulence is largely related to the toxin-producing ability of C. perfringens . This article primarily focuses on the C. perfringens type F strains that cause a very common type of human food poisoning and many cases of nonfoodborne human gastrointestinal diseases. The enteric virulence of type F strains is dependent on their ability to produce C. perfringens enterotoxin (CPE). CPE has a unique amino acid sequence but belongs structurally to the aerolysin pore-forming toxin family. The action of CPE begins with binding of the toxin to claudin receptors, followed by oligomerization of the bound toxin into a prepore on the host membrane surface. Each CPE molecule in the prepore then extends a beta-hairpin to form, collectively, a beta-barrel membrane pore that kills cells by increasing calcium influx. The cpe gene is typically encoded on the chromosome of type F food poisoning strains but is encoded by conjugative plasmids in nonfoodborne human gastrointestinal disease type F strains. During disease, CPE is produced when C. perfringens sporulates in the intestines. Beyond type F strains, C. perfringens type C strains producing beta-toxin and type A strains producing a toxin named CPILE or BEC have been associated with human intestinal infections. C. perfringens is also an important cause of enteritis, enterocolitis, and enterotoxemia in livestock and poultry due to intestinal growth and toxin production." @default.
- W2890318181 created "2018-09-27" @default.
- W2890318181 creator A5047683626 @default.
- W2890318181 creator A5088099999 @default.
- W2890318181 creator A5089450547 @default.
- W2890318181 date "2018-09-07" @default.
- W2890318181 modified "2023-10-18" @default.
- W2890318181 title "Enterotoxic Clostridia: <i>Clostridium perfringens</i> Enteric Diseases" @default.
- W2890318181 cites W1253150299 @default.
- W2890318181 cites W1489073014 @default.
- W2890318181 cites W1535825866 @default.
- W2890318181 cites W1542705459 @default.
- W2890318181 cites W1560596098 @default.
- W2890318181 cites W1571517112 @default.
- W2890318181 cites W1700331050 @default.
- W2890318181 cites W1853713578 @default.
- W2890318181 cites W1866525818 @default.
- W2890318181 cites W1924495178 @default.
- W2890318181 cites W1933260492 @default.
- W2890318181 cites W1933680207 @default.
- W2890318181 cites W1943381804 @default.
- W2890318181 cites W1951346612 @default.
- W2890318181 cites W196474878 @default.
- W2890318181 cites W1966777133 @default.
- W2890318181 cites W1968619706 @default.
- W2890318181 cites W1971713461 @default.
- W2890318181 cites W1972764676 @default.
- W2890318181 cites W1979308263 @default.
- W2890318181 cites W1999314049 @default.
- W2890318181 cites W2001756346 @default.
- W2890318181 cites W2013261860 @default.
- W2890318181 cites W2016292716 @default.
- W2890318181 cites W2016556527 @default.
- W2890318181 cites W2024432852 @default.
- W2890318181 cites W2025412305 @default.
- W2890318181 cites W2025592916 @default.
- W2890318181 cites W2027302084 @default.
- W2890318181 cites W2028032474 @default.
- W2890318181 cites W2028833608 @default.
- W2890318181 cites W2031704987 @default.
- W2890318181 cites W2031888318 @default.
- W2890318181 cites W2034601493 @default.
- W2890318181 cites W2034656439 @default.
- W2890318181 cites W2037479315 @default.
- W2890318181 cites W2045888939 @default.
- W2890318181 cites W2047515407 @default.
- W2890318181 cites W2052199264 @default.
- W2890318181 cites W2060898607 @default.
- W2890318181 cites W2063120914 @default.
- W2890318181 cites W2063648320 @default.
- W2890318181 cites W2064557781 @default.
- W2890318181 cites W2066744554 @default.
- W2890318181 cites W2067496406 @default.
- W2890318181 cites W2069431460 @default.
- W2890318181 cites W2078709216 @default.
- W2890318181 cites W2081157135 @default.
- W2890318181 cites W2083435317 @default.
- W2890318181 cites W2085627828 @default.
- W2890318181 cites W2087710101 @default.
- W2890318181 cites W2087762882 @default.
- W2890318181 cites W2088710570 @default.
- W2890318181 cites W2089483355 @default.
- W2890318181 cites W2091899525 @default.
- W2890318181 cites W2095383565 @default.
- W2890318181 cites W2098827291 @default.
- W2890318181 cites W2099792326 @default.
- W2890318181 cites W2100628434 @default.
- W2890318181 cites W2102320488 @default.
- W2890318181 cites W2104606186 @default.
- W2890318181 cites W2105267058 @default.
- W2890318181 cites W2105508603 @default.
- W2890318181 cites W2106418680 @default.
- W2890318181 cites W2106994688 @default.
- W2890318181 cites W2107204729 @default.
- W2890318181 cites W2107512674 @default.
- W2890318181 cites W2108664963 @default.
- W2890318181 cites W2109523998 @default.
- W2890318181 cites W2110235981 @default.
- W2890318181 cites W2114019116 @default.
- W2890318181 cites W2116598668 @default.
- W2890318181 cites W2117496378 @default.
- W2890318181 cites W2118196075 @default.
- W2890318181 cites W2119530493 @default.
- W2890318181 cites W2120268627 @default.
- W2890318181 cites W2121487371 @default.
- W2890318181 cites W2121961839 @default.
- W2890318181 cites W2122392249 @default.
- W2890318181 cites W2124070339 @default.
- W2890318181 cites W2124530743 @default.
- W2890318181 cites W2125061699 @default.
- W2890318181 cites W2126019224 @default.
- W2890318181 cites W2127653170 @default.
- W2890318181 cites W2128296686 @default.
- W2890318181 cites W2128591134 @default.
- W2890318181 cites W2128750262 @default.
- W2890318181 cites W2129431620 @default.
- W2890318181 cites W2130995144 @default.
- W2890318181 cites W2131148718 @default.
- W2890318181 cites W2133393514 @default.
- W2890318181 cites W2133397269 @default.