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- W2890324112 abstract "Abstract Pheochromocytomas and paragangliomas (PHEOs) are rare neuroendocrine tumors. Clinical manifestations include different cardiovascular signs and symptoms, which are related to excessive secretion of catecholamines. Catecholamine-induced cardiomyopathy in PHEO (CICMPP) is a rare but dreaded complication of PHEO. Once patient is diagnosed with this condition, the prognosis is worse and a surgical risk is much higher than expected. This article focuses on how catecholamines affect the heart and the pathophysiologic mechanism of CICMPP. The cardiovascular responses to catecholamine depend mostly on which catecholamine is released as well as the amount of catecholamine that is released. The acute release of norepinephrine and epinephrine from PHEO increases heart rate, systemic vascular resistance, myocardial contractility, and reduces venous compliance. The excessive adrenergic stimulation by catecholamine results in severe vasoconstriction and coronary vasospasm, myocardial ischemia, and subsequently damage, and necrosis. Chronically elevated catecholamine levels lead to significant desensitization of cardiac β-adrenoceptors. The increased levels of the enzyme β-adrenoceptors kinase (βARK) in the heart seems to mediate these biochemical and physiological changes that are consistently correlated with attenuated responsiveness to catecholamine stimulation. Through these mechanisms different types of cardiomyopathy (CMP) can be formed. This review discusses extensively the 3 types of cardiomyopathies that can be present in a PHEO patient. It also provides the clinical presentation and diagnostic and therapeutic algorithm in managing patients with CICMPP." @default.
- W2890324112 created "2018-09-27" @default.
- W2890324112 creator A5050590154 @default.
- W2890324112 creator A5061581962 @default.
- W2890324112 creator A5068457694 @default.
- W2890324112 creator A5085977952 @default.
- W2890324112 date "2018-09-18" @default.
- W2890324112 modified "2023-10-01" @default.
- W2890324112 title "Catecholamine-Induced Cardiomyopathy in Pheochromocytoma: How to Manage a Rare Complication in a Rare Disease?" @default.
- W2890324112 cites W137512195 @default.
- W2890324112 cites W1849053120 @default.
- W2890324112 cites W1968733745 @default.
- W2890324112 cites W1969373570 @default.
- W2890324112 cites W1969666518 @default.
- W2890324112 cites W1978471469 @default.
- W2890324112 cites W1980258822 @default.
- W2890324112 cites W1981297263 @default.
- W2890324112 cites W1981873224 @default.
- W2890324112 cites W1982562074 @default.
- W2890324112 cites W1996354277 @default.
- W2890324112 cites W1999069761 @default.
- W2890324112 cites W2000060796 @default.
- W2890324112 cites W2002730305 @default.
- W2890324112 cites W2004297171 @default.
- W2890324112 cites W2017757154 @default.
- W2890324112 cites W2021043503 @default.
- W2890324112 cites W2025937079 @default.
- W2890324112 cites W2032691607 @default.
- W2890324112 cites W2034614696 @default.
- W2890324112 cites W2034689879 @default.
- W2890324112 cites W2034710991 @default.
- W2890324112 cites W2036258707 @default.
- W2890324112 cites W2036627681 @default.
- W2890324112 cites W2038241836 @default.
- W2890324112 cites W2038764811 @default.
- W2890324112 cites W2043045234 @default.
- W2890324112 cites W2049376941 @default.
- W2890324112 cites W2049692691 @default.
- W2890324112 cites W2059802512 @default.
- W2890324112 cites W2061872007 @default.
- W2890324112 cites W2062019250 @default.
- W2890324112 cites W2063586606 @default.
- W2890324112 cites W2066365902 @default.
- W2890324112 cites W2068183487 @default.
- W2890324112 cites W2072845914 @default.
- W2890324112 cites W2080584676 @default.
- W2890324112 cites W2083364743 @default.
- W2890324112 cites W2084229517 @default.
- W2890324112 cites W2085511622 @default.
- W2890324112 cites W2085732683 @default.
- W2890324112 cites W2088502377 @default.
- W2890324112 cites W2090976070 @default.
- W2890324112 cites W2093465392 @default.
- W2890324112 cites W2094806874 @default.
- W2890324112 cites W2096422584 @default.
- W2890324112 cites W2103690977 @default.
- W2890324112 cites W2105973267 @default.
- W2890324112 cites W2107369395 @default.
- W2890324112 cites W2111316062 @default.
- W2890324112 cites W2115096210 @default.
- W2890324112 cites W2122915712 @default.
- W2890324112 cites W2135003179 @default.
- W2890324112 cites W2140003651 @default.
- W2890324112 cites W2140960716 @default.
- W2890324112 cites W2141410612 @default.
- W2890324112 cites W2146592576 @default.
- W2890324112 cites W2146672582 @default.
- W2890324112 cites W2153897596 @default.
- W2890324112 cites W2154460392 @default.
- W2890324112 cites W2157696268 @default.
- W2890324112 cites W2168421342 @default.
- W2890324112 cites W2170681483 @default.
- W2890324112 cites W2172304269 @default.
- W2890324112 cites W2202948904 @default.
- W2890324112 cites W2261025665 @default.
- W2890324112 cites W2335972944 @default.
- W2890324112 cites W2395479392 @default.
- W2890324112 cites W2397395882 @default.
- W2890324112 cites W2398176713 @default.
- W2890324112 cites W2402564818 @default.
- W2890324112 cites W2510591069 @default.
- W2890324112 cites W2558434222 @default.
- W2890324112 cites W2588846825 @default.
- W2890324112 cites W2614496215 @default.
- W2890324112 cites W2766915093 @default.
- W2890324112 cites W3049020861 @default.
- W2890324112 cites W4210969235 @default.
- W2890324112 cites W4234467251 @default.
- W2890324112 cites W83576799 @default.
- W2890324112 cites W934750154 @default.
- W2890324112 doi "https://doi.org/10.1055/a-0669-9556" @default.
- W2890324112 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/7451409" @default.
- W2890324112 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30227459" @default.
- W2890324112 hasPublicationYear "2018" @default.
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