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• W2890328213 abstract "Tolvaptan (TLV) is a diuretic agent administrated for heart failure (HF) only in Japan. Many clinical findings have been obtained from the accumulation of clinical experience, and the administration of TLV reportedly avoids causing a reduction in the renal function. In addition, TLV has been reported to exert effects other than diuresis. The early start of TLV after hospitalization shortens the length of the hospital stay, and continuous TLV after discharge extends the period until re-hospitalization of HF patients. TLV is thought to function via vasopressin V2 receptor antagonism. However, no significant differences in the long-term prognosis were noted between the group using TLV and not using TLV in the Endovascular Valve Edge-to-Edge Repair Study (EVEREST) trial, and effects other than diuresis are not useful for all HF patients. Therefore, it is necessary to identify patients who may experience effects other than diuresis with TLV administration. The accumulation of more patients and findings from further large-scale clinical trials will be necessary in order to clarify these points." @default.
• W2890328213 created "2018-09-27" @default.
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• W2890328213 date "2019-02-15" @default.
• W2890328213 modified "2023-10-10" @default.
• W2890328213 title "Hemodynamic and Hormonal Effects of Tolvaptan for Heart Failure" @default.
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• W2890328213 doi "https://doi.org/10.2169/internalmedicine.1697-18" @default.
• W2890328213 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6421149" @default.
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• W2890328213 hasPublicationYear "2019" @default.
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