Matches in SemOpenAlex for { <https://semopenalex.org/work/W2890334458> ?p ?o ?g. }
- W2890334458 endingPage "14683" @default.
- W2890334458 startingPage "14672" @default.
- W2890334458 abstract "Type I collagen is the main component of the extracellular matrix (ECM). In vitro, under a narrow window of physicochemical conditions, type I collagen self-assembles to form complex supramolecular architectures reminiscent of those found in native ECM. Presently, a major challenge in collagen-based biomaterials is to couple the delicate collagen fibrillogenesis events with a controlled shaping process in non-denaturating conditions. In this work, an ice-templating approach promoting the structuration of collagen into macroporous monoliths is used. Instead of common solvent removal procedures, a new topotactic conversion approach yielding self-assembled ordered fibrous materials is implemented. These collagen-only, non-cross-linked scaffolds exhibit uncommon mechanical properties in the wet state, with a Young’s modulus of 33 ± 12 kPa, an ultimate tensile stress of 33 ± 6 kPa, and a strain at failure of 105 ± 28%. With the help of the ice-patterned microridge features, normal human dermal fibroblasts and C2C12 murine myoblasts successfully migrate and form highly aligned populations within the resulting three-dimensional (3D) collagen scaffolds. These results open a new pathway to the development of new tissue engineering scaffolds ordered across various organization levels from the molecule to the macropore and are of particular interest for biomedical applications where large-scale 3D cell alignment is needed such as for muscular or nerve reconstruction." @default.
- W2890334458 created "2018-09-27" @default.
- W2890334458 creator A5002336596 @default.
- W2890334458 creator A5003136625 @default.
- W2890334458 creator A5042369944 @default.
- W2890334458 creator A5043859659 @default.
- W2890334458 creator A5053906395 @default.
- W2890334458 creator A5072138602 @default.
- W2890334458 creator A5079926065 @default.
- W2890334458 date "2019-03-26" @default.
- W2890334458 modified "2023-09-30" @default.
- W2890334458 title "Topotactic Fibrillogenesis of Freeze-Cast Microridged Collagen Scaffolds for 3D Cell Culture" @default.
- W2890334458 cites W151104881 @default.
- W2890334458 cites W1843958690 @default.
- W2890334458 cites W1950268352 @default.
- W2890334458 cites W1964042376 @default.
- W2890334458 cites W1970536640 @default.
- W2890334458 cites W1978828633 @default.
- W2890334458 cites W1983700870 @default.
- W2890334458 cites W1984213298 @default.
- W2890334458 cites W1986611930 @default.
- W2890334458 cites W1987448247 @default.
- W2890334458 cites W1987929539 @default.
- W2890334458 cites W1988785917 @default.
- W2890334458 cites W1998152984 @default.
- W2890334458 cites W2005840935 @default.
- W2890334458 cites W2007191221 @default.
- W2890334458 cites W2008711932 @default.
- W2890334458 cites W2014185746 @default.
- W2890334458 cites W2017399902 @default.
- W2890334458 cites W2018126662 @default.
- W2890334458 cites W2026632078 @default.
- W2890334458 cites W2030820338 @default.
- W2890334458 cites W2031396751 @default.
- W2890334458 cites W2034239774 @default.
- W2890334458 cites W2047404361 @default.
- W2890334458 cites W2048122098 @default.
- W2890334458 cites W2053537523 @default.
- W2890334458 cites W2054293005 @default.
- W2890334458 cites W2056256822 @default.
- W2890334458 cites W2071436089 @default.
- W2890334458 cites W2076173611 @default.
- W2890334458 cites W2077783392 @default.
- W2890334458 cites W2081900631 @default.
- W2890334458 cites W2083184721 @default.
- W2890334458 cites W2085163136 @default.
- W2890334458 cites W2088278979 @default.
- W2890334458 cites W2092477212 @default.
- W2890334458 cites W2096415654 @default.
- W2890334458 cites W2099276841 @default.
- W2890334458 cites W2105106837 @default.
- W2890334458 cites W2115795181 @default.
- W2890334458 cites W2125782089 @default.
- W2890334458 cites W2126617561 @default.
- W2890334458 cites W2128076390 @default.
- W2890334458 cites W2137620995 @default.
- W2890334458 cites W2138475873 @default.
- W2890334458 cites W2139586508 @default.
- W2890334458 cites W2147979150 @default.
- W2890334458 cites W2152118403 @default.
- W2890334458 cites W2158776028 @default.
- W2890334458 cites W2167243609 @default.
- W2890334458 cites W2254007494 @default.
- W2890334458 cites W2286022789 @default.
- W2890334458 cites W2300987284 @default.
- W2890334458 cites W2326859102 @default.
- W2890334458 cites W2340347191 @default.
- W2890334458 cites W2397604431 @default.
- W2890334458 cites W2510240060 @default.
- W2890334458 cites W2550556363 @default.
- W2890334458 cites W2593200545 @default.
- W2890334458 cites W2616443477 @default.
- W2890334458 cites W2625428012 @default.
- W2890334458 cites W2789654641 @default.
- W2890334458 cites W2791349152 @default.
- W2890334458 cites W2794192724 @default.
- W2890334458 cites W2806655581 @default.
- W2890334458 cites W3103727127 @default.
- W2890334458 cites W3189920043 @default.
- W2890334458 cites W4243353366 @default.
- W2890334458 cites W4246939662 @default.
- W2890334458 cites W436205860 @default.
- W2890334458 doi "https://doi.org/10.1021/acsami.9b03219" @default.
- W2890334458 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30913387" @default.
- W2890334458 hasPublicationYear "2019" @default.
- W2890334458 type Work @default.
- W2890334458 sameAs 2890334458 @default.
- W2890334458 citedByCount "41" @default.
- W2890334458 countsByYear W28903344582020 @default.
- W2890334458 countsByYear W28903344582021 @default.
- W2890334458 countsByYear W28903344582022 @default.
- W2890334458 countsByYear W28903344582023 @default.
- W2890334458 crossrefType "journal-article" @default.
- W2890334458 hasAuthorship W2890334458A5002336596 @default.
- W2890334458 hasAuthorship W2890334458A5003136625 @default.
- W2890334458 hasAuthorship W2890334458A5042369944 @default.
- W2890334458 hasAuthorship W2890334458A5043859659 @default.
- W2890334458 hasAuthorship W2890334458A5053906395 @default.