FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2890340751> ?p ?o ?g. }

• W2890340751 abstract "FOXP2 is a transcriptional repressor involved in development of the human brain and is the first gene product to be linked to the evolution of human speech. FOXP2 belongs to the FOX superfamily of proteins that share a common winged helix DNA binding domain - the forkhead domain. A divalent cation (Mg2+ or Ca2+) has been identified bound to a group of highly conserved residues in a number of FOX forkhead domain crystal structures. This work aims to investigate the role of the conserved divalent cation binding site by studying both the structure and DNA-binding function of the FOXP2 forkhead domain when in the presence and absence of either cation (Mg2+or Ca2+). The presence of the cations does not significantly alter the structure of the apo-FOXP2 forkhead domain. However, when in the presence of a cognate oligonucleotide sequence, differences are observed upon addition of divalent cation. These differences occur both in the structure and in the thermodynamic DNA binding signature of the FOXP2 forkhead domain. The incorporation of molecular dynamics simulations together with the experimental data provides us with sufficient insight so as to propose a possible role for divalent cations in the regulation of DNA binding to FOX transcription factors." @default.
• W2890340751 created "2018-09-27" @default.
• W2890340751 creator A5015603070 @default.
• W2890340751 creator A5034148261 @default.
• W2890340751 creator A5041509012 @default.
• W2890340751 creator A5084962218 @default.
• W2890340751 date "2018-11-01" @default.
• W2890340751 modified "2023-10-17" @default.
• W2890340751 title "A conserved cation binding site in the DNA binding domain of forkhead box transcription factors regulates DNA binding by FOXP2" @default.
• W2890340751 cites W107523112 @default.
• W2890340751 cites W1537110470 @default.
• W2890340751 cites W1563799197 @default.
• W2890340751 cites W1969037652 @default.
• W2890340751 cites W1969855284 @default.
• W2890340751 cites W1981147791 @default.
• W2890340751 cites W1990258459 @default.
• W2890340751 cites W1991072716 @default.
• W2890340751 cites W1994942890 @default.
• W2890340751 cites W1999363650 @default.
• W2890340751 cites W2003400094 @default.
• W2890340751 cites W2021088564 @default.
• W2890340751 cites W2026727321 @default.
• W2890340751 cites W2035503835 @default.
• W2890340751 cites W2038720420 @default.
• W2890340751 cites W2047734512 @default.
• W2890340751 cites W2059222296 @default.
• W2890340751 cites W2061189653 @default.
• W2890340751 cites W2083596769 @default.
• W2890340751 cites W2083989649 @default.
• W2890340751 cites W2091325959 @default.
• W2890340751 cites W2094549188 @default.
• W2890340751 cites W2098859322 @default.
• W2890340751 cites W2113391755 @default.
• W2890340751 cites W2140260269 @default.
• W2890340751 cites W2147962558 @default.
• W2890340751 cites W2148650779 @default.
• W2890340751 cites W2151363218 @default.
• W2890340751 cites W2155963584 @default.
• W2890340751 cites W2159778357 @default.
• W2890340751 cites W2162665049 @default.
• W2890340751 cites W2163881418 @default.
• W2890340751 cites W2299992559 @default.
• W2890340751 cites W2334551212 @default.
• W2890340751 cites W2410992991 @default.
• W2890340751 cites W2577974313 @default.
• W2890340751 cites W2792365709 @default.
• W2890340751 cites W2806362156 @default.
• W2890340751 cites W2806601547 @default.
• W2890340751 cites W2949150302 @default.
• W2890340751 cites W31529086 @default.
• W2890340751 doi "https://doi.org/10.1016/j.abb.2018.09.009" @default.
• W2890340751 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30227110" @default.
• W2890340751 hasPublicationYear "2018" @default.
• W2890340751 type Work @default.
• W2890340751 sameAs 2890340751 @default.
• W2890340751 citedByCount "3" @default.
• W2890340751 countsByYear W28903407512019 @default.
• W2890340751 countsByYear W28903407512020 @default.
• W2890340751 countsByYear W28903407512021 @default.
• W2890340751 crossrefType "journal-article" @default.
• W2890340751 hasAuthorship W2890340751A5015603070 @default.
• W2890340751 hasAuthorship W2890340751A5034148261 @default.
• W2890340751 hasAuthorship W2890340751A5041509012 @default.
• W2890340751 hasAuthorship W2890340751A5084962218 @default.
• W2890340751 hasConcept C101762097 @default.
• W2890340751 hasConcept C104317684 @default.
• W2890340751 hasConcept C107824862 @default.
• W2890340751 hasConcept C150194340 @default.
• W2890340751 hasConcept C158448853 @default.
• W2890340751 hasConcept C178790620 @default.
• W2890340751 hasConcept C185592680 @default.
• W2890340751 hasConcept C187250156 @default.
• W2890340751 hasConcept C207259873 @default.
• W2890340751 hasConcept C25166345 @default.
• W2890340751 hasConcept C2908554999 @default.
• W2890340751 hasConcept C33987129 @default.
• W2890340751 hasConcept C3662595 @default.
• W2890340751 hasConcept C5179208 @default.
• W2890340751 hasConcept C54355233 @default.
• W2890340751 hasConcept C552990157 @default.
• W2890340751 hasConcept C74884574 @default.
• W2890340751 hasConcept C86339819 @default.
• W2890340751 hasConcept C86803240 @default.
• W2890340751 hasConcept C94966510 @default.
• W2890340751 hasConceptScore W2890340751C101762097 @default.
• W2890340751 hasConceptScore W2890340751C104317684 @default.
• W2890340751 hasConceptScore W2890340751C107824862 @default.
• W2890340751 hasConceptScore W2890340751C150194340 @default.
• W2890340751 hasConceptScore W2890340751C158448853 @default.
• W2890340751 hasConceptScore W2890340751C178790620 @default.
• W2890340751 hasConceptScore W2890340751C185592680 @default.
• W2890340751 hasConceptScore W2890340751C187250156 @default.
• W2890340751 hasConceptScore W2890340751C207259873 @default.
• W2890340751 hasConceptScore W2890340751C25166345 @default.
• W2890340751 hasConceptScore W2890340751C2908554999 @default.
• W2890340751 hasConceptScore W2890340751C33987129 @default.
• W2890340751 hasConceptScore W2890340751C3662595 @default.
• W2890340751 hasConceptScore W2890340751C5179208 @default.
• W2890340751 hasConceptScore W2890340751C54355233 @default.
• W2890340751 hasConceptScore W2890340751C552990157 @default.

• next