Matches in SemOpenAlex for { <https://semopenalex.org/work/W2890348530> ?p ?o ?g. }
- W2890348530 endingPage "717" @default.
- W2890348530 startingPage "708" @default.
- W2890348530 abstract "Magnetic nanoparticles are regarded as a promising drug delivery vehicle with the improved efficacy and lowered side effects for antitumor therapy. Herein, the poly lactic-co-glycolic acid (PLGA) modified magnetic nanoplatform was synthesized using superparamagnetic γ-Fe2O3 nanoparticles (MNPs) as a core, and then labelled with polyethylenimine (PEI)-conjugated fluorescein isothiocyanate (FITC), and simultaneously loaded with antitumor drug paclitaxel (PTX) for theranostic analysis of antitumor effects investigated in human brain glioblastoma U251 cells. As a result, the prepared PEI-PLGA-MNPs showed a relatively round sphere with an average size of 80 nm approximately, and the FITC-labeling PEI-PLGA-MNPs were efficiently endocytosed by the U251 cells for cellular imaging. Moreover, the fabricated PEI-PLGA-PTX-MNPs also demonstrated an inhibition of the targeted cell proliferation and migration, and a programmed cell death, via both apoptosis modulating by a burst of reactive oxygen species (ROS) and autophagy with accumulation of autophagosomes and LC3-II signals detected in the treated glioblastoma U251 cells after uptaking. Therefore, the constructed nanoplatform could be effectively applied for simultaneous cellular imaging and drug delivery in human brain glioblastoma treatment in future." @default.
- W2890348530 created "2018-09-27" @default.
- W2890348530 creator A5007989942 @default.
- W2890348530 creator A5018574040 @default.
- W2890348530 creator A5018914638 @default.
- W2890348530 creator A5019120402 @default.
- W2890348530 creator A5021945945 @default.
- W2890348530 creator A5036202278 @default.
- W2890348530 creator A5072909687 @default.
- W2890348530 date "2018-12-01" @default.
- W2890348530 modified "2023-10-01" @default.
- W2890348530 title "Fluorescent magnetic PEI-PLGA nanoparticles loaded with paclitaxel for concurrent cell imaging, enhanced apoptosis and autophagy in human brain cancer" @default.
- W2890348530 cites W1966585685 @default.
- W2890348530 cites W1967974277 @default.
- W2890348530 cites W1968774226 @default.
- W2890348530 cites W1971752921 @default.
- W2890348530 cites W1980485904 @default.
- W2890348530 cites W1987089875 @default.
- W2890348530 cites W1989640530 @default.
- W2890348530 cites W2001837470 @default.
- W2890348530 cites W2005451446 @default.
- W2890348530 cites W2010655741 @default.
- W2890348530 cites W2013194895 @default.
- W2890348530 cites W2016404201 @default.
- W2890348530 cites W2019633596 @default.
- W2890348530 cites W2032760352 @default.
- W2890348530 cites W2041505150 @default.
- W2890348530 cites W2045120690 @default.
- W2890348530 cites W2050073028 @default.
- W2890348530 cites W2052057182 @default.
- W2890348530 cites W2062540768 @default.
- W2890348530 cites W2065527895 @default.
- W2890348530 cites W2066354221 @default.
- W2890348530 cites W2070619605 @default.
- W2890348530 cites W2072279502 @default.
- W2890348530 cites W2073918154 @default.
- W2890348530 cites W2079478685 @default.
- W2890348530 cites W2112451226 @default.
- W2890348530 cites W2124808968 @default.
- W2890348530 cites W2136502605 @default.
- W2890348530 cites W2145266849 @default.
- W2890348530 cites W2146404579 @default.
- W2890348530 cites W2313116548 @default.
- W2890348530 cites W2321866619 @default.
- W2890348530 cites W2325335768 @default.
- W2890348530 cites W2329316264 @default.
- W2890348530 cites W2335420683 @default.
- W2890348530 cites W2513030522 @default.
- W2890348530 cites W2554799456 @default.
- W2890348530 cites W2599854248 @default.
- W2890348530 cites W2605496857 @default.
- W2890348530 cites W2605957678 @default.
- W2890348530 cites W2609871459 @default.
- W2890348530 cites W2612391463 @default.
- W2890348530 cites W2627071266 @default.
- W2890348530 cites W2726342956 @default.
- W2890348530 doi "https://doi.org/10.1016/j.colsurfb.2018.09.033" @default.
- W2890348530 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30245296" @default.
- W2890348530 hasPublicationYear "2018" @default.
- W2890348530 type Work @default.
- W2890348530 sameAs 2890348530 @default.
- W2890348530 citedByCount "37" @default.
- W2890348530 countsByYear W28903485302018 @default.
- W2890348530 countsByYear W28903485302019 @default.
- W2890348530 countsByYear W28903485302020 @default.
- W2890348530 countsByYear W28903485302021 @default.
- W2890348530 countsByYear W28903485302022 @default.
- W2890348530 countsByYear W28903485302023 @default.
- W2890348530 crossrefType "journal-article" @default.
- W2890348530 hasAuthorship W2890348530A5007989942 @default.
- W2890348530 hasAuthorship W2890348530A5018574040 @default.
- W2890348530 hasAuthorship W2890348530A5018914638 @default.
- W2890348530 hasAuthorship W2890348530A5019120402 @default.
- W2890348530 hasAuthorship W2890348530A5021945945 @default.
- W2890348530 hasAuthorship W2890348530A5036202278 @default.
- W2890348530 hasAuthorship W2890348530A5072909687 @default.
- W2890348530 hasConcept C104317684 @default.
- W2890348530 hasConcept C121332964 @default.
- W2890348530 hasConcept C121608353 @default.
- W2890348530 hasConcept C12554922 @default.
- W2890348530 hasConcept C155672457 @default.
- W2890348530 hasConcept C171250308 @default.
- W2890348530 hasConcept C185592680 @default.
- W2890348530 hasConcept C190283241 @default.
- W2890348530 hasConcept C192562407 @default.
- W2890348530 hasConcept C203522944 @default.
- W2890348530 hasConcept C2775925850 @default.
- W2890348530 hasConcept C2777019933 @default.
- W2890348530 hasConcept C2777292972 @default.
- W2890348530 hasConcept C2779820397 @default.
- W2890348530 hasConcept C2780165375 @default.
- W2890348530 hasConcept C502942594 @default.
- W2890348530 hasConcept C54009773 @default.
- W2890348530 hasConcept C54355233 @default.
- W2890348530 hasConcept C55493867 @default.
- W2890348530 hasConcept C62520636 @default.
- W2890348530 hasConcept C86803240 @default.
- W2890348530 hasConcept C91881484 @default.