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• W2890375100 abstract "The world's oceans contain an enormous biodiversity of organisms living in a wide range of environments, and the survival of those organisms depends on a diversity of biologically active compounds. Here, we explore how this situation can be exploited to discover bioactive marine molecules that can lead to the development of pharmaceutical products for use in medicine. The biodiversity and biopharmaceutical potential of molecules derived from marine ecosystems is greater than those already derived from terrestrial sources. Bioactive compounds have been discovered from marine fungi, bacteria, cyanobacteria, seaweeds, tunicates, polychaetes, corals, sponges, jellyfish, sea urchins, molluscs, crustaceans, and fish. Many of the compounds have been named after the organism from which they were isolated. This chapter discusses marine-derived molecules with antitumor therapeutic potential, molecules for the treatment of pain, and marine peptides with antimicrobial activity. Updates are given on methods used in biopharmaceutical research, including technologies to explore pathophysiology, ways to determine that a compound demonstrates the proper pharmacological and pharmacokinetic characteristics, culture methods, and cell detachment methods. Advances in marine natural product development, and in marine and human genomics, will lead to better personalized medicine and precision biomolecular therapeutics. The goal is to discover additional bioactive molecules that will deliver marine biopharmaceuticals of greater potency, higher efficacy, and with fewer side effects. Along with the harvest of marine organisms from the wild and from cell culture, organic chemists must continue to use synthetic chemistry to scale up the production of approved biopharmaceutical products for medicinal purposes." @default.
• W2890375100 created "2018-09-27" @default.
• W2890375100 creator A5016537225 @default.
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• W2890375100 date "2018-03-19" @default.
• W2890375100 modified "2023-09-26" @default.
• W2890375100 title "Bioactive Marine Molecules and Derivatives with Biopharmaceutical Potential" @default.
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• W2890375100 doi "https://doi.org/10.1002/9783527801718.ch19" @default.
• W2890375100 hasPublicationYear "2018" @default.
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