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- W2890375712 abstract "SUMMARY Morphogen signaling forms an activity gradient and instructs cell identities in a signaling strength-dependent manner to pattern developing tissues. However, developing tissues also undergo dynamic morphogenesis, which may produce cells with unfit morphogen signaling and consequent noisy morphogen gradient. Here we show that a cell competition-related system corrects such noisy morphogen gradients. Zebrafish imaging analyses of the Wnt/β-catenin signaling-gradient, which acts as a morphogen to establish embryonic anterior-posterior patterning, revealed that unfit cells with abnormal Wnt/β-catenin activity spontaneously appear and produce noise in the Wnt/β-catenin-gradient. Communication between the unfit and neighboring fit cells via cadherin proteins stimulates the apoptosis of the unfit cells by activating Smad signaling and reactive oxygen species production. This unfit cell elimination is required for proper Wnt/β-catenin-gradient formation and consequent anterior-posterior patterning. Because this gradient controls patterning not only in the embryo but also in adult tissues, this system may support tissue robustness and disease prevention." @default.
- W2890375712 created "2018-09-27" @default.
- W2890375712 creator A5003039911 @default.
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- W2890375712 date "2018-09-25" @default.
- W2890375712 modified "2023-10-03" @default.
- W2890375712 title "Cell competition corrects noisy Wnt morphogen gradients to achieve robust patterning" @default.
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- W2890375712 doi "https://doi.org/10.1101/423814" @default.
- W2890375712 hasPublicationYear "2018" @default.
- W2890375712 type Work @default.