FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2890401410> ?p ?o ?g. }

• W2890401410 endingPage "429" @default.
• W2890401410 startingPage "422" @default.
• W2890401410 abstract "Toxoplasma gondii is responsible for one of the most prevalent infections in people. T. gondii profilin (TgPr) is a protein integral to parasite movement and cellular invasion. Murine TLRs has been described to bind TgPr. Furthermore, more recently, human TLR5 has been described to recognise recombinant TgPr, as well as bacterial flagellin. In addition to infections in humans, T. gondii infects farm animals, but little information is available about its innate recognition. We aimed to investigate whether, similarly to their human orthologue, bovine and porcine TLR5 could also be stimulated by TgPr by using a combination of reporter cell lines expressing full length TLR5 from each species as well as primary cells. Although human and bovine TLR5-transfected cells responded to flagellin, no response was detected upon stimulation with profilin. Furthermore, TgPr failed to elicit IL-6 secretion in human peripheral blood mononuclear cells and CD14 + monocytes. In contrast, exposure of RAW cells, known to express TLR11, to TgPr slightly increased the IL-6 response. Our data cast doubts on the possibility that profilin is a specific ligand for human TLR5 and bovine TLR5. This leaves the immunogenic properties of this potential target antigen (Ag) uncharacterised outside of the murine system." @default.
• W2890401410 created "2018-09-27" @default.
• W2890401410 creator A5017342065 @default.
• W2890401410 creator A5029387671 @default.
• W2890401410 creator A5036808064 @default.
• W2890401410 creator A5053864933 @default.
• W2890401410 creator A5061861242 @default.
• W2890401410 date "2018-09-08" @default.
• W2890401410 modified "2023-10-17" @default.
• W2890401410 title "<i>Toxoplasma gondii</i> profilin does not stimulate an innate immune response through bovine or human TLR5" @default.
• W2890401410 cites W1519633296 @default.
• W2890401410 cites W1646363625 @default.
• W2890401410 cites W1761339305 @default.
• W2890401410 cites W1793115003 @default.
• W2890401410 cites W1970279912 @default.
• W2890401410 cites W1980273234 @default.
• W2890401410 cites W1986784789 @default.
• W2890401410 cites W1995586746 @default.
• W2890401410 cites W1998757281 @default.
• W2890401410 cites W2003486723 @default.
• W2890401410 cites W2009219530 @default.
• W2890401410 cites W2009521410 @default.
• W2890401410 cites W2012408448 @default.
• W2890401410 cites W2021361448 @default.
• W2890401410 cites W2037863616 @default.
• W2890401410 cites W2045303929 @default.
• W2890401410 cites W2045777328 @default.
• W2890401410 cites W2062621293 @default.
• W2890401410 cites W2075744120 @default.
• W2890401410 cites W2097659338 @default.
• W2890401410 cites W2111200149 @default.
• W2890401410 cites W2114637517 @default.
• W2890401410 cites W2118261210 @default.
• W2890401410 cites W2118390380 @default.
• W2890401410 cites W2128103945 @default.
• W2890401410 cites W2130985618 @default.
• W2890401410 cites W2131025240 @default.
• W2890401410 cites W2133205789 @default.
• W2890401410 cites W2163095748 @default.
• W2890401410 cites W2167230961 @default.
• W2890401410 cites W2346168596 @default.
• W2890401410 cites W2410443770 @default.
• W2890401410 cites W2594373644 @default.
• W2890401410 cites W2883914499 @default.
• W2890401410 cites W4211218717 @default.
• W2890401410 doi "https://doi.org/10.1177/1753425918798450" @default.
• W2890401410 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6830871" @default.
• W2890401410 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30196747" @default.
• W2890401410 hasPublicationYear "2018" @default.
• W2890401410 type Work @default.
• W2890401410 sameAs 2890401410 @default.
• W2890401410 citedByCount "6" @default.
• W2890401410 countsByYear W28904014102019 @default.
• W2890401410 countsByYear W28904014102020 @default.
• W2890401410 countsByYear W28904014102022 @default.
• W2890401410 countsByYear W28904014102023 @default.
• W2890401410 crossrefType "journal-article" @default.
• W2890401410 hasAuthorship W2890401410A5017342065 @default.
• W2890401410 hasAuthorship W2890401410A5029387671 @default.
• W2890401410 hasAuthorship W2890401410A5036808064 @default.
• W2890401410 hasAuthorship W2890401410A5053864933 @default.
• W2890401410 hasAuthorship W2890401410A5061861242 @default.
• W2890401410 hasBestOaLocation W28904014101 @default.
• W2890401410 hasConcept C136449434 @default.
• W2890401410 hasConcept C137061746 @default.
• W2890401410 hasConcept C142669718 @default.
• W2890401410 hasConcept C147483822 @default.
• W2890401410 hasConcept C1491633281 @default.
• W2890401410 hasConcept C159047783 @default.
• W2890401410 hasConcept C159654299 @default.
• W2890401410 hasConcept C170493617 @default.
• W2890401410 hasConcept C202751555 @default.
• W2890401410 hasConcept C203014093 @default.
• W2890401410 hasConcept C203253989 @default.
• W2890401410 hasConcept C2776709828 @default.
• W2890401410 hasConcept C2777338127 @default.
• W2890401410 hasConcept C2778128430 @default.
• W2890401410 hasConcept C2993400109 @default.
• W2890401410 hasConcept C38117629 @default.
• W2890401410 hasConcept C54009773 @default.
• W2890401410 hasConcept C54355233 @default.
• W2890401410 hasConcept C55493867 @default.
• W2890401410 hasConcept C81885089 @default.
• W2890401410 hasConcept C86803240 @default.
• W2890401410 hasConcept C8891405 @default.
• W2890401410 hasConcept C89423630 @default.
• W2890401410 hasConcept C95444343 @default.
• W2890401410 hasConceptScore W2890401410C136449434 @default.
• W2890401410 hasConceptScore W2890401410C137061746 @default.
• W2890401410 hasConceptScore W2890401410C142669718 @default.
• W2890401410 hasConceptScore W2890401410C147483822 @default.
• W2890401410 hasConceptScore W2890401410C1491633281 @default.
• W2890401410 hasConceptScore W2890401410C159047783 @default.
• W2890401410 hasConceptScore W2890401410C159654299 @default.
• W2890401410 hasConceptScore W2890401410C170493617 @default.
• W2890401410 hasConceptScore W2890401410C202751555 @default.
• W2890401410 hasConceptScore W2890401410C203014093 @default.
• W2890401410 hasConceptScore W2890401410C203253989 @default.

• next