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- W2890403763 abstract "To evaluate the risk of blastogenesis birth defects (those occurring within the first four weeks after conception) in children conceived with IVF and non-IVF ART (subfertile), IVF siblings, and fertile controls. Cohort study, with exposure groups defined as IVF-exposed, siblings of IVF-exposed, subfertile, and fertile. IVF cycles in SART CORS resulting in live births in 2004-13 were linked to birth certificates and birth defects registries in four States (NY, TX, MA, and NC). All other births to each IVF-treated woman were also identified (IVF siblings). A 10:1 sample of non-IVF births in the same month as the IVF births were selected as controls; those with infertility treatment indicated on the birth certificate (but not in SART CORS) were categorized as subfertile, all others were categorized as fertile. Risks were modeled separately by plurality using logistic regression (AOR, 95% CI), adjusted for maternal age, race and ethnicity, education, parity, pre-gestational and gestational diabetes and hypertension, State and year of birth; children of fertile women were the reference group. The study population included 942,920 children (see table). Analyses limiting the IVF group to cycles with autologous oocytes, partner sperm, and fresh embryos are shown by (*). There was an increased risk of blastogenesis birth defects for singleton IVF births, but not for multiples born with IVF. There also appeared to be an increased risk in subfertile children, especially in multiple births.Tabled 1FertileIVFIVF*IVF SiblingsSubfertileAllN, Children811,989106,72172,51518,6515,559SingletonsN, Children789,30657,57138,59117,4433,815Rate/10,000All birth defects377.7485.7482.5431.7474.4Rate/10,000Blastogenesis defects21.927.326.918.328.8AOR, 95% CIBlastogenesis defects1.00 (Reference)1.43 (1.18, 1.74)1.53 (1.22, 1.90)1.06 (0.74, 1.52)1.57 (0.86, 2.85)MultiplesN, Children22,68349,15033,9241,2081,744Rate/10,000All defects619.8708.0708.9860.9756.9Rate/10,000Blastogenesis defects37.035.635.449.768.8AOR, 95% CIBlastogenesis defects1.00 (Reference)1.00 (0.72, 1.39)0.93 (0.65, 1.32)1.25 (0.52, 2.97)2.36 (1.25, 4.47) Open table in a new tab" @default.
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- W2890403763 date "2018-09-01" @default.
- W2890403763 modified "2023-10-18" @default.
- W2890403763 title "Risk of blastogenesis birth defects in IVF, non-IVF ART, and fertile births" @default.
- W2890403763 doi "https://doi.org/10.1016/j.fertnstert.2018.07.572" @default.
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