FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2890418976> ?p ?o ?g. }

• W2890418976 endingPage "48" @default.
• W2890418976 startingPage "39" @default.
• W2890418976 abstract "Jab1 overexpression correlates with poor prognosis in breast cancer patients, suggestting that targeting the aberrant Jab1 signaling in breast cancer could be a promising strategy. In the current study, we investigate the hypothesis that Jab1 positively regulates the DNA repair protein Rad51 and, in turn, the cellular response of breast cancer to chemotherapy with adriamycin and cisplatin. High-throughput mRNA sequencing (RNA-Seq) data from 113 normal and 1109 tumor tissues (obtained from TCGA) were integrated to our analysis to give further support to our findings. We found that Jab1 was overexpressed in adriamycin-resistant breast cancer cell MCF-7R compared with parental MCF-7 cells, and that knockdown of Jab1 expression conferred cellular sensitivity to adriamycin and cisplatin both in vivo and in vitro. By contrast, exogenous Jab1 expression enhanced the resistance of breast cancer cells to adriamycin and cisplatin. Moreover, we discovered that Jab1 positively regulated Rad51 in p53-dependent manner and that overexpression of Rad51 conferred cellular resistance to adriamycin and cisplatin in Jab1-deficient cells. Data from TCGA further validated an correlation between Jab1 and Rad51 in breast cancer, and elevated Jab1 and Rad51 associated with poor survival in breast cancer patients. Our findings indicate that Jab1 association with Rad51 plays an important role in cellular response to chemotherapy in breast cancer." @default.
• W2890418976 created "2018-09-27" @default.
• W2890418976 creator A5001882175 @default.
• W2890418976 creator A5007321647 @default.
• W2890418976 creator A5030878372 @default.
• W2890418976 creator A5035295977 @default.
• W2890418976 creator A5040831062 @default.
• W2890418976 creator A5050564186 @default.
• W2890418976 creator A5062442835 @default.
• W2890418976 creator A5071554002 @default.
• W2890418976 date "2019-01-01" @default.
• W2890418976 modified "2023-10-17" @default.
• W2890418976 title "Jab1/Cops5 contributes to chemoresistance in breast cancer by regulating Rad51" @default.
• W2890418976 cites W1976385056 @default.
• W2890418976 cites W1987345634 @default.
• W2890418976 cites W1990026377 @default.
• W2890418976 cites W2002195359 @default.
• W2890418976 cites W2003581594 @default.
• W2890418976 cites W2025402420 @default.
• W2890418976 cites W2034979953 @default.
• W2890418976 cites W2040273148 @default.
• W2890418976 cites W2064341025 @default.
• W2890418976 cites W2074699503 @default.
• W2890418976 cites W2075958155 @default.
• W2890418976 cites W2086840140 @default.
• W2890418976 cites W2094328090 @default.
• W2890418976 cites W2123825855 @default.
• W2890418976 cites W2124472585 @default.
• W2890418976 cites W2126404651 @default.
• W2890418976 cites W2126592114 @default.
• W2890418976 cites W2130146081 @default.
• W2890418976 cites W2136216485 @default.
• W2890418976 cites W2153458528 @default.
• W2890418976 cites W2159862107 @default.
• W2890418976 cites W2461244735 @default.
• W2890418976 cites W2513505388 @default.
• W2890418976 cites W2534266625 @default.
• W2890418976 cites W2554320328 @default.
• W2890418976 cites W2591746754 @default.
• W2890418976 cites W2610280068 @default.
• W2890418976 cites W2613629789 @default.
• W2890418976 cites W2626575385 @default.
• W2890418976 cites W2731454206 @default.
• W2890418976 cites W2737083047 @default.
• W2890418976 cites W2763077107 @default.
• W2890418976 cites W2771808827 @default.
• W2890418976 cites W2772410085 @default.
• W2890418976 cites W2789605409 @default.
• W2890418976 cites W2792768542 @default.
• W2890418976 cites W2821752803 @default.
• W2890418976 doi "https://doi.org/10.1016/j.cellsig.2018.09.010" @default.
• W2890418976 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30244171" @default.
• W2890418976 hasPublicationYear "2019" @default.
• W2890418976 type Work @default.
• W2890418976 sameAs 2890418976 @default.
• W2890418976 citedByCount "18" @default.
• W2890418976 countsByYear W28904189762019 @default.
• W2890418976 countsByYear W28904189762020 @default.
• W2890418976 countsByYear W28904189762021 @default.
• W2890418976 countsByYear W28904189762022 @default.
• W2890418976 countsByYear W28904189762023 @default.
• W2890418976 crossrefType "journal-article" @default.
• W2890418976 hasAuthorship W2890418976A5001882175 @default.
• W2890418976 hasAuthorship W2890418976A5007321647 @default.
• W2890418976 hasAuthorship W2890418976A5030878372 @default.
• W2890418976 hasAuthorship W2890418976A5035295977 @default.
• W2890418976 hasAuthorship W2890418976A5040831062 @default.
• W2890418976 hasAuthorship W2890418976A5050564186 @default.
• W2890418976 hasAuthorship W2890418976A5062442835 @default.
• W2890418976 hasAuthorship W2890418976A5071554002 @default.
• W2890418976 hasConcept C121608353 @default.
• W2890418976 hasConcept C126322002 @default.
• W2890418976 hasConcept C134935766 @default.
• W2890418976 hasConcept C173396325 @default.
• W2890418976 hasConcept C2776694085 @default.
• W2890418976 hasConcept C2778239845 @default.
• W2890418976 hasConcept C2779012473 @default.
• W2890418976 hasConcept C2781303535 @default.
• W2890418976 hasConcept C502942594 @default.
• W2890418976 hasConcept C530470458 @default.
• W2890418976 hasConcept C54355233 @default.
• W2890418976 hasConcept C552990157 @default.
• W2890418976 hasConcept C71924100 @default.
• W2890418976 hasConcept C81885089 @default.
• W2890418976 hasConcept C86803240 @default.
• W2890418976 hasConcept C96232424 @default.
• W2890418976 hasConceptScore W2890418976C121608353 @default.
• W2890418976 hasConceptScore W2890418976C126322002 @default.
• W2890418976 hasConceptScore W2890418976C134935766 @default.
• W2890418976 hasConceptScore W2890418976C173396325 @default.
• W2890418976 hasConceptScore W2890418976C2776694085 @default.
• W2890418976 hasConceptScore W2890418976C2778239845 @default.
• W2890418976 hasConceptScore W2890418976C2779012473 @default.
• W2890418976 hasConceptScore W2890418976C2781303535 @default.
• W2890418976 hasConceptScore W2890418976C502942594 @default.
• W2890418976 hasConceptScore W2890418976C530470458 @default.
• W2890418976 hasConceptScore W2890418976C54355233 @default.
• W2890418976 hasConceptScore W2890418976C552990157 @default.

• next