FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2890422929> ?p ?o ?g. }

• W2890422929 abstract "The relationship between growth and immune phenotypes has been presented in the context of physiology and energy allocation theory, but has rarely been explained genetically in humans. As more summary statistics of genome-wide association studies (GWAS) become available, it is increasingly possible to explore the genetic relationship between traits at the level of genome-wide summary statistics. In this study, publicly available summary statistics of growth and immune related traits were used to evaluate the genetic correlation coefficients between immune and growth traits, as well as the cause and effect relationship between them. In addition, pleiotropic variants and KEGG pathways were identified. As a result, we found negative correlations between birthweight and immune cell count phenotypes, a positive correlation between childhood head circumference and eosinophil counts, and positive or negative correlations between childhood body mass index and immune phenotypes. Statistically significant negative effects of immune cell count phenotypes on human height, and a slight but significant negative influence of human height on allergic disease were also observed. A total of 98 genomic regions were identified as containing variants potentially related to both immunity and growth. Some variants, such as rs3184504 located in SH2B3, rs13107325 in SLC39A8, and rs1260326 located in GCKR, which have been identified to be pleiotropic SNPs among other traits, were found to also be related to growth and immune traits in this study. Meanwhile, the most frequent overlapping KEGG pathways between growth and immune phenotypes were autoimmune related pathways. Pleiotropic pathways such as the adipocytokine signaling pathway and JAK-STAT signaling pathway were also identified to be significant. The results of this study indicate the complex genetic relationship between growth and immune phenotypes, and reveal the genetic background of their correlation in the context of pleiotropy." @default.
• W2890422929 created "2018-09-27" @default.
• W2890422929 creator A5001716002 @default.
• W2890422929 creator A5003310703 @default.
• W2890422929 creator A5009588850 @default.
• W2890422929 creator A5018586372 @default.
• W2890422929 creator A5024916524 @default.
• W2890422929 creator A5073916751 @default.
• W2890422929 creator A5077558876 @default.
• W2890422929 creator A5080160602 @default.
• W2890422929 date "2018-09-14" @default.
• W2890422929 modified "2023-10-03" @default.
• W2890422929 title "Exploring the Genetic Correlation Between Growth and Immunity Based on Summary Statistics of Genome-Wide Association Studies" @default.
• W2890422929 cites W1548331719 @default.
• W2890422929 cites W1604449639 @default.
• W2890422929 cites W1782833144 @default.
• W2890422929 cites W1832133707 @default.
• W2890422929 cites W1858714005 @default.
• W2890422929 cites W1928849416 @default.
• W2890422929 cites W1976620258 @default.
• W2890422929 cites W1977825487 @default.
• W2890422929 cites W1983270011 @default.
• W2890422929 cites W1984050812 @default.
• W2890422929 cites W1984068087 @default.
• W2890422929 cites W1996299724 @default.
• W2890422929 cites W1996606664 @default.
• W2890422929 cites W2001823075 @default.
• W2890422929 cites W2015578131 @default.
• W2890422929 cites W2033132992 @default.
• W2890422929 cites W2040148846 @default.
• W2890422929 cites W2047540788 @default.
• W2890422929 cites W2057811513 @default.
• W2890422929 cites W2060156648 @default.
• W2890422929 cites W2068162513 @default.
• W2890422929 cites W2073836327 @default.
• W2890422929 cites W2080215939 @default.
• W2890422929 cites W2083497058 @default.
• W2890422929 cites W2100847604 @default.
• W2890422929 cites W2103783427 @default.
• W2890422929 cites W2106294125 @default.
• W2890422929 cites W2114609796 @default.
• W2890422929 cites W2117446594 @default.
• W2890422929 cites W2118216748 @default.
• W2890422929 cites W2120226362 @default.
• W2890422929 cites W2122737396 @default.
• W2890422929 cites W2130767371 @default.
• W2890422929 cites W2131241257 @default.
• W2890422929 cites W2139852278 @default.
• W2890422929 cites W2143877047 @default.
• W2890422929 cites W2145714319 @default.
• W2890422929 cites W2155615155 @default.
• W2890422929 cites W2161633633 @default.
• W2890422929 cites W2167776875 @default.
• W2890422929 cites W2195783463 @default.
• W2890422929 cites W2216513861 @default.
• W2890422929 cites W2268001801 @default.
• W2890422929 cites W2300091156 @default.
• W2890422929 cites W2306167448 @default.
• W2890422929 cites W2328393125 @default.
• W2890422929 cites W2360159874 @default.
• W2890422929 cites W2401811918 @default.
• W2890422929 cites W2503030347 @default.
• W2890422929 cites W2510387549 @default.
• W2890422929 cites W2550031966 @default.
• W2890422929 cites W2569467431 @default.
• W2890422929 cites W2571503386 @default.
• W2890422929 cites W2600809019 @default.
• W2890422929 cites W2725988230 @default.
• W2890422929 cites W2738307791 @default.
• W2890422929 cites W2748443982 @default.
• W2890422929 cites W2765256236 @default.
• W2890422929 cites W2768238915 @default.
• W2890422929 cites W2780232486 @default.
• W2890422929 cites W2781803148 @default.
• W2890422929 cites W2784021290 @default.
• W2890422929 cites W2789833091 @default.
• W2890422929 cites W2794999358 @default.
• W2890422929 cites W2797237250 @default.
• W2890422929 cites W2949543964 @default.
• W2890422929 cites W2950757888 @default.
• W2890422929 cites W79977280 @default.
• W2890422929 doi "https://doi.org/10.3389/fgene.2018.00393" @default.
• W2890422929 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6149433" @default.
• W2890422929 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30271426" @default.
• W2890422929 hasPublicationYear "2018" @default.
• W2890422929 type Work @default.
• W2890422929 sameAs 2890422929 @default.
• W2890422929 citedByCount "11" @default.
• W2890422929 countsByYear W28904229292019 @default.
• W2890422929 countsByYear W28904229292020 @default.
• W2890422929 countsByYear W28904229292021 @default.
• W2890422929 countsByYear W28904229292022 @default.
• W2890422929 countsByYear W28904229292023 @default.
• W2890422929 crossrefType "journal-article" @default.
• W2890422929 hasAuthorship W2890422929A5001716002 @default.
• W2890422929 hasAuthorship W2890422929A5003310703 @default.
• W2890422929 hasAuthorship W2890422929A5009588850 @default.
• W2890422929 hasAuthorship W2890422929A5018586372 @default.
• W2890422929 hasAuthorship W2890422929A5024916524 @default.
• W2890422929 hasAuthorship W2890422929A5073916751 @default.

• next