Matches in SemOpenAlex for { <https://semopenalex.org/work/W2890423752> ?p ?o ?g. }
- W2890423752 abstract "Abstract Biological regulatory network architectures are multi-scale in their function and can adaptively acquire new functions. Gene knockout (KO) experiments provide an established experimental approach not just for studying gene function, but also for unraveling regulatory networks in which a gene and its gene product are involved. Here we study the regulatory architecture of Escherichia coli K-12 MG1655 by applying adaptive laboratory evolution (ALE) to metabolic gene KO strains. Multi-omic analysis reveal a common overall schema describing the process of adaptation whereby perturbations in metabolite concentrations lead regulatory networks to produce suboptimal states, whose function is subsequently altered and re-optimized through acquisition of mutations during ALE. These results indicate that metabolite levels, through metabolite-transcription factor interactions, have a dominant role in determining the function of a multi-scale regulatory architecture that has been molded by evolution." @default.
- W2890423752 created "2018-09-27" @default.
- W2890423752 creator A5002596498 @default.
- W2890423752 creator A5002819499 @default.
- W2890423752 creator A5007010641 @default.
- W2890423752 creator A5009834334 @default.
- W2890423752 creator A5048081015 @default.
- W2890423752 creator A5062042072 @default.
- W2890423752 creator A5071564078 @default.
- W2890423752 creator A5072991489 @default.
- W2890423752 date "2018-09-18" @default.
- W2890423752 modified "2023-10-02" @default.
- W2890423752 title "Evolution of gene knockout strains of E. coli reveal regulatory architectures governed by metabolism" @default.
- W2890423752 cites W1483361015 @default.
- W2890423752 cites W1501334198 @default.
- W2890423752 cites W1507458182 @default.
- W2890423752 cites W1535946290 @default.
- W2890423752 cites W1541235420 @default.
- W2890423752 cites W1560930772 @default.
- W2890423752 cites W1653658786 @default.
- W2890423752 cites W1740334656 @default.
- W2890423752 cites W1822348759 @default.
- W2890423752 cites W1916502439 @default.
- W2890423752 cites W1952732684 @default.
- W2890423752 cites W1969348568 @default.
- W2890423752 cites W1970558305 @default.
- W2890423752 cites W1982309495 @default.
- W2890423752 cites W1986082851 @default.
- W2890423752 cites W1987420757 @default.
- W2890423752 cites W1995808589 @default.
- W2890423752 cites W1998728673 @default.
- W2890423752 cites W1999888715 @default.
- W2890423752 cites W2004964623 @default.
- W2890423752 cites W2011514820 @default.
- W2890423752 cites W2012977051 @default.
- W2890423752 cites W2016097940 @default.
- W2890423752 cites W2016350681 @default.
- W2890423752 cites W2018927787 @default.
- W2890423752 cites W2019100231 @default.
- W2890423752 cites W2019516978 @default.
- W2890423752 cites W2022292851 @default.
- W2890423752 cites W2022829653 @default.
- W2890423752 cites W2029667189 @default.
- W2890423752 cites W2029745103 @default.
- W2890423752 cites W2039751039 @default.
- W2890423752 cites W2054117348 @default.
- W2890423752 cites W2055238593 @default.
- W2890423752 cites W2058713700 @default.
- W2890423752 cites W2068970107 @default.
- W2890423752 cites W2069821830 @default.
- W2890423752 cites W2071735418 @default.
- W2890423752 cites W2071952329 @default.
- W2890423752 cites W2078712330 @default.
- W2890423752 cites W2082978049 @default.
- W2890423752 cites W2084314118 @default.
- W2890423752 cites W2084401890 @default.
- W2890423752 cites W2091187888 @default.
- W2890423752 cites W2096378434 @default.
- W2890423752 cites W2097744318 @default.
- W2890423752 cites W2098489069 @default.
- W2890423752 cites W2100104150 @default.
- W2890423752 cites W2104640980 @default.
- W2890423752 cites W2107870682 @default.
- W2890423752 cites W2111796963 @default.
- W2890423752 cites W2111906329 @default.
- W2890423752 cites W2111967267 @default.
- W2890423752 cites W2115941371 @default.
- W2890423752 cites W2116137883 @default.
- W2890423752 cites W2116791869 @default.
- W2890423752 cites W2117357746 @default.
- W2890423752 cites W2117467324 @default.
- W2890423752 cites W2117891907 @default.
- W2890423752 cites W2124371326 @default.
- W2890423752 cites W2124737787 @default.
- W2890423752 cites W2124985265 @default.
- W2890423752 cites W2126156443 @default.
- W2890423752 cites W2130479394 @default.
- W2890423752 cites W2134138595 @default.
- W2890423752 cites W2140611297 @default.
- W2890423752 cites W2140729594 @default.
- W2890423752 cites W2140959043 @default.
- W2890423752 cites W2141458291 @default.
- W2890423752 cites W2141776893 @default.
- W2890423752 cites W2142437744 @default.
- W2890423752 cites W2144068357 @default.
- W2890423752 cites W2144907278 @default.
- W2890423752 cites W2147819069 @default.
- W2890423752 cites W2148277388 @default.
- W2890423752 cites W2150093433 @default.
- W2890423752 cites W2150381125 @default.
- W2890423752 cites W2153238155 @default.
- W2890423752 cites W2154430676 @default.
- W2890423752 cites W2158057347 @default.
- W2890423752 cites W2162467456 @default.
- W2890423752 cites W2163433435 @default.
- W2890423752 cites W2165373392 @default.
- W2890423752 cites W2167893089 @default.
- W2890423752 cites W2167942713 @default.
- W2890423752 cites W2169641851 @default.
- W2890423752 cites W2170568588 @default.