FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2890423931> ?p ?o ?g. }

• W2890423931 endingPage "42" @default.
• W2890423931 startingPage "37" @default.
• W2890423931 abstract "Lynch syndrome is an inherited cancer disorder that causes an increased lifetime risk of various types of cancers. Endometrial cancer is the most common extracolonic cancer in Lynch syndrome. Guidelines recommend that patients with endometrial cancer younger than 50 years of age should be evaluated for Lynch syndrome. Molecular analysis of the mismatch repair genes and EPCAM gene is required for a definitive diagnosis of Lynch syndrome.To report the mutation analysis of mismatch repair genes using targeted next-generation sequencing in endometrial cancer diagnosed patients <50 years of age.Retrospective cross-sectional study.Seventy-nine endometrial cancer diagnosed patients <50 years of age underwent genetic counseling. They were selected among 1094 consecutive endometrial cancer patients between 2006 and 2017. Molecular analysis of MLH1, MSH2, and MSH6 genes was performed in 79 patients by using next-generation sequencing. Deletion/duplication analysis of mismatch repair genes and EPCAM gene was also performed in 79 patients by using the multiplex ligation-dependent probe amplification method.Germline testing of mismatch repair genes was performed in 79 endometrial cancer patients. Lynch syndrome was confirmed in 4 patients (5%; 4/79). A total of 14 variants (6 in MSH2, 5 in MLH1, 3 in MSH6 genes) were found in 14 patients. Four variants were assessed as pathogenic/likely pathogenic, and 10 variants were assessed as variants of uncertain significance.Lynch syndrome should be investigated in patients diagnosed with endometrial cancer that are less than 50 years of age due to the increased lifetime risk of developing cancer." @default.
• W2890423931 created "2018-09-27" @default.
• W2890423931 creator A5005275046 @default.
• W2890423931 creator A5027466015 @default.
• W2890423931 creator A5056990662 @default.
• W2890423931 creator A5070355672 @default.
• W2890423931 date "2019-01-10" @default.
• W2890423931 modified "2023-09-25" @default.
• W2890423931 title "Targeted Next-Generation Sequencing of MLH1, MSH2, and MSH6 Genes in Patients with Endometrial Carcinoma under 50 Years of Age" @default.
• W2890423931 cites W1968153494 @default.
• W2890423931 cites W1970413157 @default.
• W2890423931 cites W1980740976 @default.
• W2890423931 cites W2001538359 @default.
• W2890423931 cites W2021341670 @default.
• W2890423931 cites W2051978340 @default.
• W2890423931 cites W2059145105 @default.
• W2890423931 cites W2067560254 @default.
• W2890423931 cites W2084988326 @default.
• W2890423931 cites W2085554251 @default.
• W2890423931 cites W2087900265 @default.
• W2890423931 cites W2099162862 @default.
• W2890423931 cites W2109378245 @default.
• W2890423931 cites W2112237372 @default.
• W2890423931 cites W2117131162 @default.
• W2890423931 cites W2123860717 @default.
• W2890423931 cites W2130400016 @default.
• W2890423931 cites W2132123037 @default.
• W2890423931 cites W2137098494 @default.
• W2890423931 cites W2146263344 @default.
• W2890423931 cites W2162077547 @default.
• W2890423931 cites W2545241042 @default.
• W2890423931 cites W2569423334 @default.
• W2890423931 cites W2611972631 @default.
• W2890423931 cites W2613184396 @default.
• W2890423931 doi "https://doi.org/10.4274/balkanmedj.2018.0922" @default.
• W2890423931 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6335935" @default.
• W2890423931 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30238922" @default.
• W2890423931 hasPublicationYear "2019" @default.
• W2890423931 type Work @default.
• W2890423931 sameAs 2890423931 @default.
• W2890423931 citedByCount "4" @default.
• W2890423931 countsByYear W28904239312020 @default.
• W2890423931 countsByYear W28904239312021 @default.
• W2890423931 countsByYear W28904239312022 @default.
• W2890423931 crossrefType "journal-article" @default.
• W2890423931 hasAuthorship W2890423931A5005275046 @default.
• W2890423931 hasAuthorship W2890423931A5027466015 @default.
• W2890423931 hasAuthorship W2890423931A5056990662 @default.
• W2890423931 hasAuthorship W2890423931A5070355672 @default.
• W2890423931 hasBestOaLocation W28904239311 @default.
• W2890423931 hasConcept C104317684 @default.
• W2890423931 hasConcept C111425858 @default.
• W2890423931 hasConcept C120599132 @default.
• W2890423931 hasConcept C121608353 @default.
• W2890423931 hasConcept C126322002 @default.
• W2890423931 hasConcept C13514818 @default.
• W2890423931 hasConcept C143998085 @default.
• W2890423931 hasConcept C2776559941 @default.
• W2890423931 hasConcept C2776674815 @default.
• W2890423931 hasConcept C2777088508 @default.
• W2890423931 hasConcept C2778677574 @default.
• W2890423931 hasConcept C2779115348 @default.
• W2890423931 hasConcept C36823959 @default.
• W2890423931 hasConcept C501734568 @default.
• W2890423931 hasConcept C526805850 @default.
• W2890423931 hasConcept C54355233 @default.
• W2890423931 hasConcept C60748783 @default.
• W2890423931 hasConcept C71924100 @default.
• W2890423931 hasConcept C86803240 @default.
• W2890423931 hasConceptScore W2890423931C104317684 @default.
• W2890423931 hasConceptScore W2890423931C111425858 @default.
• W2890423931 hasConceptScore W2890423931C120599132 @default.
• W2890423931 hasConceptScore W2890423931C121608353 @default.
• W2890423931 hasConceptScore W2890423931C126322002 @default.
• W2890423931 hasConceptScore W2890423931C13514818 @default.
• W2890423931 hasConceptScore W2890423931C143998085 @default.
• W2890423931 hasConceptScore W2890423931C2776559941 @default.
• W2890423931 hasConceptScore W2890423931C2776674815 @default.
• W2890423931 hasConceptScore W2890423931C2777088508 @default.
• W2890423931 hasConceptScore W2890423931C2778677574 @default.
• W2890423931 hasConceptScore W2890423931C2779115348 @default.
• W2890423931 hasConceptScore W2890423931C36823959 @default.
• W2890423931 hasConceptScore W2890423931C501734568 @default.
• W2890423931 hasConceptScore W2890423931C526805850 @default.
• W2890423931 hasConceptScore W2890423931C54355233 @default.
• W2890423931 hasConceptScore W2890423931C60748783 @default.
• W2890423931 hasConceptScore W2890423931C71924100 @default.
• W2890423931 hasConceptScore W2890423931C86803240 @default.
• W2890423931 hasLocation W28904239311 @default.
• W2890423931 hasLocation W28904239312 @default.
• W2890423931 hasLocation W28904239313 @default.
• W2890423931 hasLocation W28904239314 @default.
• W2890423931 hasLocation W28904239315 @default.
• W2890423931 hasOpenAccess W2890423931 @default.
• W2890423931 hasPrimaryLocation W28904239311 @default.
• W2890423931 hasRelatedWork W1797625457 @default.
• W2890423931 hasRelatedWork W1980465409 @default.
• W2890423931 hasRelatedWork W2094774960 @default.

• next