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- W2890424934 abstract "Abstract An autorhythmic population of excitatory neurons in the brainstem pre-Bötzinger complex is a critical component of the mammalian respiratory oscillator. Two intrinsic neuronal biophysical mechanisms—a persistent sodium current ( I NaP ) and a calcium-activated non-selective cationic current ( I CAN )—were proposed to individually or in combination generate cellular-and circuit-level oscillations, but their roles are debated without resolution. We re-examined these roles with a new computational model of an excitatory population with randomly distributed I NaP and I CAN conductances and synaptic connections. This model robustly reproduces experimental data showing contrary to previous hypotheses, rhythm generation is independent of I CAN activation, which instead determines population activity amplitude. The novel insight is that this occurs when I CAN is primarily activated by neuronal calcium fluxes driven by synaptic mechanisms. Rhythm depends critically on I NaP in a subpopulation forming the rhythmogenic kernel. The model explains how the rhythm and amplitude of respiratory oscillations involve distinct biophysical mechanisms." @default.
- W2890424934 created "2018-09-27" @default.
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- W2890424934 date "2018-09-12" @default.
- W2890424934 modified "2023-09-26" @default.
- W2890424934 title "Biophysical mechanisms in the mammalian respiratory oscillator re-examined with a new data-driven computational model" @default.
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- W2890424934 doi "https://doi.org/10.1101/415190" @default.
- W2890424934 hasPublicationYear "2018" @default.
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