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- W2890425265 abstract "Human tuberculosis (TB) is amongst the oldest and deadliest human bacterial diseases that pose major health, social and economic burden at a global level. Current regimens for TB treatment are lengthy, expensive and ineffective to emerging drug resistant strains. Thus, there is an urgent need for identification and development of novel TB drugs and drug regimens with comprehensive and specific mechanisms of action. Many medicinal plants are traditionally used for TB treatment. While some of their phytochemical composition has been elucidated, their mechanisms of action are not well understood. Insufficient knowledge on Mycobacterium tuberculosis (M.tb) biology and the complex nature of its infection limit the effectiveness of current screening-based methods used for TB drug discovery. Nonetheless, application of metabolomics tools within the 'omics' approaches, could provide an alternative method of elucidating the mechanism of action of medicinal plants. Metabolomics aims at high throughput detection, quantification and identification of metabolites in biological samples. Changes in the concentration of specific metabolites in a biological sample indicate changes in the metabolic pathways. In this paper review and discuss novel methods that involve application of metabolomics to drug discovery and the understanding of mechanisms of action of medicinal plants with anti-TB activity. Current knowledge on TB infection, anti-TB drugs and mechanisms of action are also included. We further highlight metabolism of M. tuberculosis and the potential drug targets, as well as current approaches in the development of anti-TB drugs." @default.
- W2890425265 created "2018-09-27" @default.
- W2890425265 creator A5038756960 @default.
- W2890425265 creator A5060288078 @default.
- W2890425265 creator A5060443901 @default.
- W2890425265 creator A5068307772 @default.
- W2890425265 creator A5070209942 @default.
- W2890425265 creator A5086294117 @default.
- W2890425265 date "2018-10-01" @default.
- W2890425265 modified "2023-10-16" @default.
- W2890425265 title "Application of metabolomics to drug discovery and understanding the mechanisms of action of medicinal plants with anti‐tuberculosis activity" @default.
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