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- W2890425775 abstract "Introduction: Obstructive sleep apnea (OSA) is associated with incident cardiovascular disease (CVD), which may reflect dysregulation of pathways leading to atherosclerosis. Inflammation and adaptive immunity participate in the pathogenesis of atherosclerosis, and may be influenced by OSA-related stresses. No prior community-based study has examined the associations of OSA with both leukocytes and serum inflammatory markers. Hypothesis: Biomarkers of inflammation are associated with OSA severity in a community-based cohort. We particularly focused on White Blood Cell (WBC), which has not been well-studied in association with OSA. Since OSA has been associated more strongly with CVD in middle-age vs. old age, we explored potential age modification. Methods: We analyzed data from MESA participants who underwent polysomnography in conjunction with Exam 5 (2010-13) and had available biomarkers from that exam. The primary analysis (n=1344) modeled WBC count and Cystatin-C as outcomes (available for largest sub..." @default.
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- W2890425775 date "2016-11-11" @default.
- W2890425775 modified "2023-09-27" @default.
- W2890425775 title "Abstract 13147: Obstructive Sleep Apnea Associates With Elevated Leukocytes and Markers of Inflammation in the Multi-Ethnic Study of Atherosclerosis (MESA)" @default.
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