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- W2890427718 abstract "Abstract Cucurbitacin B (CuB) is a natural tetracyclic triterpene product that displays antitumor activity against a wide variety of cancers. In this study, we explored the antipancreatic cancer activity of CuB via the inhibition of expression of the cancer‐related long noncoding RNA, actin filament‐associated protein 1‐antisense RNA 1 (AFAP1‐AS1). CuB arrested pancreatic cancer (PC) cells in the G2/M cell cycle phase by suppressing the expression of AFAP1‐AS1. Insights into the mechanisms of competing endogenous RNAs (ceRNAs) gained from bioinformatics analysis and luciferase activity assays showed that the epidermal growth factor receptor (EGFR) and AFAP1‐AS1 directly compete for miR‐146b‐5p binding. CuB‐induced high miR‐146b‐5p expression and inhibited the expression of AFAP1‐AS1. In summary, reducing the expression of endogenous AFAP1‐AS1 effectively increased the available concentration of miR‐146b‐5p in PC, whereas miR‐146b‐5p overexpression prevented the expression of endogenous AFAP1‐AS1. In particular, we hypothesized that AFAP1‐AS1 might act as a ceRNA, effectively becoming a sponge for miR‐146b‐5p, thereby activating the expression of the EGFR. Thus, CuB suppresses the proliferation, in vitro and in vivo, of PC cells through the ceRNA effect of AFAP1‐AS1 on miR‐146b‐5p." @default.
- W2890427718 created "2018-09-27" @default.
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- W2890427718 date "2018-09-12" @default.
- W2890427718 modified "2023-09-26" @default.
- W2890427718 title "Cucurbitacin B suppresses proliferation of pancreatic cancer cells by ceRNA: Effect of miR‐146b‐5p and lncRNA‐AFAP1‐AS1" @default.
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- W2890427718 doi "https://doi.org/10.1002/jcp.27264" @default.
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