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- W2890429708 abstract "Objective: To determine specific electroencephalography (EEG) patterns in WNV neuroinvasive disease. Background: West Nile virus (WNV) is a flaviviridae virus transmitted by mosquitoes. Neuroinvasive disease occurs in less than 1% of those infected, and may manifest as meningitis, encephalitis and/or acute flaccid paralysis. We aimed to determine the frequency of seizures as well as to describe specific EEG patterns in WNV neuroinvasive disease. Design/Methods: A retrospective chart review was conducted searching for patients 18–99 years of age, admitted to Mayo Clinic (Arizona, Jacksonville, and Rochester), from January 2000 to May 2017, with a diagnosis of WNV neuroinvasive disease. Inclusion criteria consisted of 1) presence of WNV IgM antibodies in both cerebrospinal fluid (CSF) and serum, 2) presence of WNV IgM antibodies in serum only and CSF consistent with meningitis, or 3) presence of serum or CSF WNV PCR and CSF consistent with meningitis. EEG reports were classified in categories based on the presence of epileptiform activity, focal slowing, triphasic waves, and frontal intermittent rhythmic delta activity (FIRDA). Results: Thirty-five patients were identified. EEG results were categorized as follows: generalized slowing (n=31), epileptiform discharges 17. 1% (n=6), focal slowing 17. 1% (n=6), FIRDA 11. 4% (n=4) and triphasic waves in 20% (n=7). Pure generalized slowing was seen in 37% of patients (n=13). An anterior predominance of EEG abnormalities was observed in 54. 5% (n=6) of the 11 patients with epileptiform discharges and/or focal slowing. Conclusions: Patients with WNV neuroinvasive disease can present with a multitude of EEG abnormalities ranging from non-specific slowing, epileptiform activity, focal slowing, triphasic waves and FIRDA. In our study, an anterior predominance of EEG changes was observed in more than half of those with epileptiform discharges and/or focal slowing. In patients with meningoencephalitis of undetermined etiology, a corresponding EEG demonstrating an anterior predominance of abnormalities should prompt testing for West Nile virus. Disclosure: Dr. Parsons has nothing to disclose. Dr Grill has nothing to disclose. Dr. Feyissa has nothing to disclose. Dr. Britton has nothing to disclose. Dr Hocker has nothing to disclose. Dr Crepeau has nothing to disclose." @default.
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- W2890429708 date "2018-04-10" @default.
- W2890429708 modified "2023-09-22" @default.
- W2890429708 title "Electroencephalography in West Nile virus Neuroinvasive Disease (P3.273)" @default.
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