FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2890431325> ?p ?o ?g. }

• W2890431325 endingPage "454" @default.
• W2890431325 startingPage "445" @default.
• W2890431325 abstract "The objective of this study is to evaluate the feasibility of obtaining extended release of tacrolimus by a novel combination of lipid-based solid dispersion and matrix-type extended release tablet techniques. Tacrolimus solid dispersion was prepared using glycerylbehenate (Compritol® ATO888) and Pluronic F127 as the carrier materials with hot-melt method, which was then blended with hydrogel matrix materials, such as HPMC and lactose, the powders were directly compressed into tablets. In vitro drug release tests were carried out to evaluate the performance of the solid dispersions and the tablets. The dissolution rate of tacrolimus was significantly improved by the lipid-based solid dispersion, and the incorporation of HPC into the solid dispersion obviously improved its stability after storage. Extended release tablets loaded with tacrolimus solid dispersion showed prolonged drug release patterns over 24 h, the release patterns of the tablets can be tailored by the compositions of the matrix materials, including the types and content of HPMCs. A modified processing method that directly mixed the melted solid dispersion with HPMC powders improved the uniformity of the solid dispersion inside the tablet matrix and release profile. The release data of the extended release tablet fitted well to the Korsmeyer-Peppas model with n value of 0.85, which suggested diffusion- and erosion-controlled release mechanism. The combination of lipid-based solid dispersion and HPMC hydrogel matrix may find wide applications in the extended release dosage forms of high potent, water-insoluble drugs." @default.
• W2890431325 created "2018-09-27" @default.
• W2890431325 creator A5039017936 @default.
• W2890431325 creator A5044164513 @default.
• W2890431325 creator A5060414497 @default.
• W2890431325 creator A5063481044 @default.
• W2890431325 creator A5072911367 @default.
• W2890431325 creator A5081675173 @default.
• W2890431325 date "2019-07-01" @default.
• W2890431325 modified "2023-09-23" @default.
• W2890431325 title "Extended tacrolimus release via the combination of lipid-based solid dispersion and HPMC hydrogel matrix tablets" @default.
• W2890431325 cites W1480151031 @default.
• W2890431325 cites W1658324192 @default.
• W2890431325 cites W1964314651 @default.
• W2890431325 cites W1973255646 @default.
• W2890431325 cites W1979814913 @default.
• W2890431325 cites W1991301979 @default.
• W2890431325 cites W1995012019 @default.
• W2890431325 cites W2000234125 @default.
• W2890431325 cites W2004895912 @default.
• W2890431325 cites W2005363709 @default.
• W2890431325 cites W2011241157 @default.
• W2890431325 cites W2027774666 @default.
• W2890431325 cites W2028222947 @default.
• W2890431325 cites W2032730584 @default.
• W2890431325 cites W2041016731 @default.
• W2890431325 cites W2045846731 @default.
• W2890431325 cites W2062270321 @default.
• W2890431325 cites W2084224847 @default.
• W2890431325 cites W2089557861 @default.
• W2890431325 cites W2092823011 @default.
• W2890431325 cites W2109613416 @default.
• W2890431325 cites W2136187304 @default.
• W2890431325 cites W2140053263 @default.
• W2890431325 cites W2158858347 @default.
• W2890431325 cites W2165973960 @default.
• W2890431325 cites W2186337469 @default.
• W2890431325 cites W2239089246 @default.
• W2890431325 cites W2297650735 @default.
• W2890431325 cites W2486325144 @default.
• W2890431325 cites W2500719151 @default.
• W2890431325 cites W2531696597 @default.
• W2890431325 cites W2547361514 @default.
• W2890431325 cites W2736210084 @default.
• W2890431325 cites W2740064334 @default.
• W2890431325 cites W2750818704 @default.
• W2890431325 cites W2782175582 @default.
• W2890431325 doi "https://doi.org/10.1016/j.ajps.2018.08.001" @default.
• W2890431325 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/7032121" @default.
• W2890431325 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/32104473" @default.
• W2890431325 hasPublicationYear "2019" @default.
• W2890431325 type Work @default.
• W2890431325 sameAs 2890431325 @default.
• W2890431325 citedByCount "19" @default.
• W2890431325 countsByYear W28904313252019 @default.
• W2890431325 countsByYear W28904313252020 @default.
• W2890431325 countsByYear W28904313252021 @default.
• W2890431325 countsByYear W28904313252022 @default.
• W2890431325 countsByYear W28904313252023 @default.
• W2890431325 crossrefType "journal-article" @default.
• W2890431325 hasAuthorship W2890431325A5039017936 @default.
• W2890431325 hasAuthorship W2890431325A5044164513 @default.
• W2890431325 hasAuthorship W2890431325A5060414497 @default.
• W2890431325 hasAuthorship W2890431325A5063481044 @default.
• W2890431325 hasAuthorship W2890431325A5072911367 @default.
• W2890431325 hasAuthorship W2890431325A5081675173 @default.
• W2890431325 hasBestOaLocation W28904313251 @default.
• W2890431325 hasConcept C101335993 @default.
• W2890431325 hasConcept C106487976 @default.
• W2890431325 hasConcept C120665830 @default.
• W2890431325 hasConcept C121332964 @default.
• W2890431325 hasConcept C127413603 @default.
• W2890431325 hasConcept C15920480 @default.
• W2890431325 hasConcept C159985019 @default.
• W2890431325 hasConcept C163588942 @default.
• W2890431325 hasConcept C171250308 @default.
• W2890431325 hasConcept C177562468 @default.
• W2890431325 hasConcept C178790620 @default.
• W2890431325 hasConcept C185592680 @default.
• W2890431325 hasConcept C192562407 @default.
• W2890431325 hasConcept C199529486 @default.
• W2890431325 hasConcept C2779820397 @default.
• W2890431325 hasConcept C42360764 @default.
• W2890431325 hasConcept C43617362 @default.
• W2890431325 hasConcept C521977710 @default.
• W2890431325 hasConcept C77281830 @default.
• W2890431325 hasConcept C88380143 @default.
• W2890431325 hasConceptScore W2890431325C101335993 @default.
• W2890431325 hasConceptScore W2890431325C106487976 @default.
• W2890431325 hasConceptScore W2890431325C120665830 @default.
• W2890431325 hasConceptScore W2890431325C121332964 @default.
• W2890431325 hasConceptScore W2890431325C127413603 @default.
• W2890431325 hasConceptScore W2890431325C15920480 @default.
• W2890431325 hasConceptScore W2890431325C159985019 @default.
• W2890431325 hasConceptScore W2890431325C163588942 @default.
• W2890431325 hasConceptScore W2890431325C171250308 @default.
• W2890431325 hasConceptScore W2890431325C177562468 @default.
• W2890431325 hasConceptScore W2890431325C178790620 @default.

• next