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• W2890432462 abstract "Abstract Hypercapnia, the elevation of CO 2 in blood and tissues, commonly occurs in severe acute and chronic respiratory diseases, and is associated with increased risk of mortality. Recent studies have shown that hypercapnia adversely affects innate immunity, host defense, lung edema clearance and cell proliferation. Airway epithelial dysfunction is a feature of advanced lung disease, but the effect of hypercapnia on airway epithelium is unknown. Thus, in the current study we examined the effect of normoxic hypercapnia (20% CO 2 for 24 h) vs normocapnia (5% CO 2 ), on global gene expression in differentiated normal human airway epithelial cells. Gene expression was assessed on Affymetrix microarrays, and subjected to gene ontology analysis for biological process and cluster-network representation. We found that hypercapnia downregulated the expression of 183 genes and upregulated 126. Among these, major gene clusters linked to immune responses and nucleosome assembly were largely downregulated, while lipid metabolism genes were largely upregulated. The overwhelming majority of these genes were not previously known to be regulated by CO 2 . These changes in gene expression indicate the potential for hypercapnia to impact bronchial epithelial cell function in ways that may contribute to poor clinical outcomes in patients with severe acute or advanced chronic lung diseases." @default.
• W2890432462 created "2018-09-27" @default.
• W2890432462 creator A5011793208 @default.
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• W2890432462 date "2018-09-10" @default.
• W2890432462 modified "2023-10-13" @default.
• W2890432462 title "Hypercapnia Alters Expression of Immune Response, Nucleosome Assembly and Lipid Metabolism Genes in Differentiated Human Bronchial Epithelial Cells" @default.
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• W2890432462 cites W1918184794 @default.
• W2890432462 cites W1921305060 @default.
• W2890432462 cites W1928868997 @default.
• W2890432462 cites W1939952622 @default.
• W2890432462 cites W1968637358 @default.
• W2890432462 cites W1968690870 @default.
• W2890432462 cites W1969600641 @default.
• W2890432462 cites W1973530626 @default.
• W2890432462 cites W1985422736 @default.
• W2890432462 cites W1988403514 @default.
• W2890432462 cites W1993362950 @default.
• W2890432462 cites W1998100955 @default.
• W2890432462 cites W1998435868 @default.
• W2890432462 cites W2000971263 @default.
• W2890432462 cites W2003544664 @default.
• W2890432462 cites W2007199806 @default.
• W2890432462 cites W2007962988 @default.
• W2890432462 cites W2008036841 @default.
• W2890432462 cites W2009198292 @default.
• W2890432462 cites W2011285661 @default.
• W2890432462 cites W2022267672 @default.
• W2890432462 cites W2039769151 @default.
• W2890432462 cites W2040909238 @default.
• W2890432462 cites W2045873707 @default.
• W2890432462 cites W2051682127 @default.
• W2890432462 cites W2052685738 @default.
• W2890432462 cites W2057942269 @default.
• W2890432462 cites W2064257198 @default.
• W2890432462 cites W2065691491 @default.
• W2890432462 cites W2066605916 @default.
• W2890432462 cites W2066716562 @default.
• W2890432462 cites W2072331982 @default.
• W2890432462 cites W2074128267 @default.
• W2890432462 cites W2086375279 @default.
• W2890432462 cites W2087714421 @default.
• W2890432462 cites W2087796014 @default.
• W2890432462 cites W2094255773 @default.
• W2890432462 cites W2099540110 @default.
• W2890432462 cites W2105260061 @default.
• W2890432462 cites W2106651585 @default.
• W2890432462 cites W2107277218 @default.
• W2890432462 cites W2109890581 @default.
• W2890432462 cites W2115565682 @default.
• W2890432462 cites W2118755647 @default.
• W2890432462 cites W2119446930 @default.
• W2890432462 cites W2122746019 @default.
• W2890432462 cites W2124523627 @default.
• W2890432462 cites W2133416903 @default.
• W2890432462 cites W2136623765 @default.
• W2890432462 cites W2137131296 @default.
• W2890432462 cites W2141802106 @default.
• W2890432462 cites W2143767849 @default.
• W2890432462 cites W2146091325 @default.
• W2890432462 cites W2146512944 @default.
• W2890432462 cites W2148908421 @default.
• W2890432462 cites W2153936765 @default.
• W2890432462 cites W2153960708 @default.
• W2890432462 cites W2154457032 @default.
• W2890432462 cites W2159613168 @default.
• W2890432462 cites W2160697532 @default.
• W2890432462 cites W2161607837 @default.
• W2890432462 cites W2161834691 @default.
• W2890432462 cites W2164906420 @default.
• W2890432462 cites W2166432084 @default.
• W2890432462 cites W2168504646 @default.
• W2890432462 cites W2176695138 @default.
• W2890432462 cites W2192080449 @default.
• W2890432462 cites W2195971187 @default.
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• W2890432462 cites W2408483783 @default.
• W2890432462 cites W2480992917 @default.
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• W2890432462 cites W2615946421 @default.
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• W2890432462 doi "https://doi.org/10.1038/s41598-018-32008-x" @default.
• W2890432462 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6131151" @default.
• W2890432462 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30202079" @default.
• W2890432462 hasPublicationYear "2018" @default.
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