FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2890433326> ?p ?o ?g. }

• W2890433326 endingPage "733" @default.
• W2890433326 startingPage "724" @default.
• W2890433326 abstract "Triple-negative breast cancer (TNBC) is one of the most aggressive and poor prognosis breast cancers. Currently, chemotherapy with conventional cytotoxic agents is the only available option to treat TNBC. Hence, we identified new therapeutic agents against TNBC from traditional Chinese medicine Radix Bupleuri and unveiled the molecule mechanism of anti-TNBC effects. Multi-component bioactivity and structure-guided methods were used to identify the most effective anti-TNBC compound Saikosaponin D (SSD) from Radix Bupleuri. Cell viability and apoptosis assays were employed to demonstrate the effect of SSD on the proliferation and apoptosis of TNBC cells. Dynamic mass redistribution assay, TopFlash assay, western blotting, and special agonist were applied to dissect the potential molecular mechanisms of SSD. We screened twenty fractions in Radix Bupleuri and identified SSD as the most effective component to inhibit the proliferation of TNBC cells. Investigating the interaction of SSD with the frequently overexpressed targets in TNBC led to the identification that it markedly suppressed Wnt/β-catenin signaling, but did not act on epidermal growth factor receptor and neurotensin receptor-1. Moreover, we demonstrated that SSD significantly repressed β-catenin and its downstream target genes, resulting in TNBC cell apoptosis. Specifically, docking of SSD to the crystal structure of β-catenin suggested that SSD interacted with β-catenin via hydrogen bonds and hydrophobic interaction. We identified the most effective component SSD from Radix Bupleuri in inhibiting the proliferation of TNBC cells by targeting β-catenin signaling. Given the important role of Wnt/β-catenin signaling in breast cancer, SSD may present an opportunity to discover new therapeutics for the treatment of TNBC." @default.
• W2890433326 created "2018-09-27" @default.
• W2890433326 creator A5002402073 @default.
• W2890433326 creator A5013178268 @default.
• W2890433326 creator A5016841529 @default.
• W2890433326 creator A5035169366 @default.
• W2890433326 creator A5038623685 @default.
• W2890433326 creator A5040502320 @default.
• W2890433326 creator A5046463041 @default.
• W2890433326 creator A5054872738 @default.
• W2890433326 creator A5069648479 @default.
• W2890433326 creator A5075195709 @default.
• W2890433326 creator A5086716026 @default.
• W2890433326 creator A5091716767 @default.
• W2890433326 date "2018-12-01" @default.
• W2890433326 modified "2023-10-16" @default.
• W2890433326 title "Saikosaponin D from Radix Bupleuri suppresses triple-negative breast cancer cell growth by targeting β-catenin signaling" @default.
• W2890433326 cites W1256125786 @default.
• W2890433326 cites W1588334150 @default.
• W2890433326 cites W1857266517 @default.
• W2890433326 cites W1966614045 @default.
• W2890433326 cites W1970655448 @default.
• W2890433326 cites W1973632911 @default.
• W2890433326 cites W1973927012 @default.
• W2890433326 cites W1988206259 @default.
• W2890433326 cites W1993306472 @default.
• W2890433326 cites W2005364473 @default.
• W2890433326 cites W2008870230 @default.
• W2890433326 cites W2017005705 @default.
• W2890433326 cites W2024898148 @default.
• W2890433326 cites W203309426 @default.
• W2890433326 cites W2033636905 @default.
• W2890433326 cites W2036223112 @default.
• W2890433326 cites W2042341230 @default.
• W2890433326 cites W2056357661 @default.
• W2890433326 cites W2089373315 @default.
• W2890433326 cites W2098537494 @default.
• W2890433326 cites W2119393905 @default.
• W2890433326 cites W2133540952 @default.
• W2890433326 cites W2145617194 @default.
• W2890433326 cites W2202599200 @default.
• W2890433326 cites W2314621992 @default.
• W2890433326 cites W2347180983 @default.
• W2890433326 cites W2352943218 @default.
• W2890433326 cites W2402636472 @default.
• W2890433326 cites W2561596885 @default.
• W2890433326 cites W2568695943 @default.
• W2890433326 cites W2603705142 @default.
• W2890433326 cites W2604586440 @default.
• W2890433326 cites W2619491072 @default.
• W2890433326 cites W2727009687 @default.
• W2890433326 doi "https://doi.org/10.1016/j.biopha.2018.09.038" @default.
• W2890433326 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30248540" @default.
• W2890433326 hasPublicationYear "2018" @default.
• W2890433326 type Work @default.
• W2890433326 sameAs 2890433326 @default.
• W2890433326 citedByCount "39" @default.
• W2890433326 countsByYear W28904333262018 @default.
• W2890433326 countsByYear W28904333262019 @default.
• W2890433326 countsByYear W28904333262020 @default.
• W2890433326 countsByYear W28904333262021 @default.
• W2890433326 countsByYear W28904333262022 @default.
• W2890433326 countsByYear W28904333262023 @default.
• W2890433326 crossrefType "journal-article" @default.
• W2890433326 hasAuthorship W2890433326A5002402073 @default.
• W2890433326 hasAuthorship W2890433326A5013178268 @default.
• W2890433326 hasAuthorship W2890433326A5016841529 @default.
• W2890433326 hasAuthorship W2890433326A5035169366 @default.
• W2890433326 hasAuthorship W2890433326A5038623685 @default.
• W2890433326 hasAuthorship W2890433326A5040502320 @default.
• W2890433326 hasAuthorship W2890433326A5046463041 @default.
• W2890433326 hasAuthorship W2890433326A5054872738 @default.
• W2890433326 hasAuthorship W2890433326A5069648479 @default.
• W2890433326 hasAuthorship W2890433326A5075195709 @default.
• W2890433326 hasAuthorship W2890433326A5086716026 @default.
• W2890433326 hasAuthorship W2890433326A5091716767 @default.
• W2890433326 hasBestOaLocation W28904333261 @default.
• W2890433326 hasConcept C121608353 @default.
• W2890433326 hasConcept C126322002 @default.
• W2890433326 hasConcept C137620995 @default.
• W2890433326 hasConcept C185592680 @default.
• W2890433326 hasConcept C2780110267 @default.
• W2890433326 hasConcept C30145163 @default.
• W2890433326 hasConcept C502942594 @default.
• W2890433326 hasConcept C530470458 @default.
• W2890433326 hasConcept C55493867 @default.
• W2890433326 hasConcept C62112901 @default.
• W2890433326 hasConcept C62478195 @default.
• W2890433326 hasConcept C71924100 @default.
• W2890433326 hasConcept C86803240 @default.
• W2890433326 hasConcept C95444343 @default.
• W2890433326 hasConceptScore W2890433326C121608353 @default.
• W2890433326 hasConceptScore W2890433326C126322002 @default.
• W2890433326 hasConceptScore W2890433326C137620995 @default.
• W2890433326 hasConceptScore W2890433326C185592680 @default.
• W2890433326 hasConceptScore W2890433326C2780110267 @default.
• W2890433326 hasConceptScore W2890433326C30145163 @default.
• W2890433326 hasConceptScore W2890433326C502942594 @default.

• next