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• W2890434911 abstract "<b><i>Objectives:</i></b> To assess the safety and efficacy of bromelain plus tamsulosin versus tamsulosin alone as medical expulsive therapy (MET) for promoting spontaneous stone passage (SSP) of symptomatic distal ureter stones. <b><i>Patients and Methods:</i></b> One-hundred-fourteen patients with a 4–10 mm distal ureteral stone were enrolled (Group A). Patients self-administered daily bromelain with tamsulosin for 30 days or until SSP or intervention was mandatory. Patients were compared to those from a control group taking tamsulosin as MET (Group B) and matched for the following factors: sex, age ±10%, stone diameter. A logistic regression model evaluated bromelain and the ureteral stone diameter as explanatory variables. <b><i>Results:</i></b> SSP rates were 87.7 vs. 75.4% for group A vs. group B respectively (<i>p</i> = 0.016); with no difference observed for the time to self-reported stone expulsion (11.68 vs. 11.57 days; <i>p</i> = 0.91). Considering larger stones (&#x3e; 5 mm), the SSP rate was 83.3% in group A and 61% in group B (<i>p</i> &#x3c; 0.01). With each millimeter increment of stone diameter, the probability of SSP decreased by 59.1% (<i>p</i> &#x3c; 0.0001), while it increased of 3.3 when bromelain was present. Only 3 cases of tamsulosin-related adverse events were recorded. <b><i>Conclusion:</i></b> The association of bromelain and tamsulosin as MET increases the probability of SSP of symptomatic distal ureteral stones, with no bromelain-related side effects recorded." @default.
• W2890434911 created "2018-09-27" @default.
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• W2890434911 date "2018-09-18" @default.
• W2890434911 modified "2023-10-18" @default.
• W2890434911 title "Medical Expulsive Therapy for Symptomatic Distal Ureter Stones: Is the Combination of Bromelain and Tamsulosin More Effective than Tamsulosin Alone? Preliminary Results of a Single-Center Study" @default.
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• W2890434911 doi "https://doi.org/10.1159/000493158" @default.
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