Matches in SemOpenAlex for { <https://semopenalex.org/work/W2890437514> ?p ?o ?g. }
Showing items 1 to 98 of
98
with 100 items per page.
- W2890437514 endingPage "545" @default.
- W2890437514 startingPage "538" @default.
- W2890437514 abstract "Introduction: Cardiopulmonary bypass (CPB) is known to cause a systemic inflammatory and immune response. Objective: An in-vitro model of cardiotomy suction was designed to quantify the effects of incrementally increased air-blood exposure on leucocyte marker CD11b and cytokine activation in two common anticoagulants, heparin and citrate. Methods: Fresh human blood was exposed to increasing amounts of air flow for ten minutes. Leucocyte and cytokine levels were measured prior to and after ten minutes of air flow. Cytokine levels were also measured after air exposure when incubated for 24 hours at 37 o C. Results: Leucocyte activation, measured by CD11b, was elevated between baseline and air flow rates up to 50 mL/min. After 10 minutes of air exposure, no measured cytokine levels were elevated. After 24 hours of incubation, cytokine levels of TNFα, IL-10, IL-6, and IL-8 were elevated. However, only IL-8 was significantly elevated in citrated blood, but not in heparinized blood, when compared to baseline samples that were also incubated for 24 hours. Conclusion: This study investigates CD11b levels in response to an air stimulus in blood that was anticoagulated with citrate or heparin. Exposure to an air stimulus activates leucocytes. Activation of CD11b was less when using heparin as an anticoagulant compared to citrate. Cytokine activation occurs with air stimulation, but levels do not immediately rise, indicating that time is required to generate free cytokines." @default.
- W2890437514 created "2018-09-27" @default.
- W2890437514 creator A5031022861 @default.
- W2890437514 creator A5034009146 @default.
- W2890437514 creator A5072179089 @default.
- W2890437514 creator A5083335307 @default.
- W2890437514 creator A5085108379 @default.
- W2890437514 creator A5034595650 @default.
- W2890437514 date "2018-04-11" @default.
- W2890437514 modified "2023-09-29" @default.
- W2890437514 title "The effect of air exposure on leucocyte and cytokine activation in an in-vitro model of cardiotomy suction" @default.
- W2890437514 cites W1965058977 @default.
- W2890437514 cites W1982082299 @default.
- W2890437514 cites W1986299008 @default.
- W2890437514 cites W1988751520 @default.
- W2890437514 cites W1999100399 @default.
- W2890437514 cites W2000049023 @default.
- W2890437514 cites W2006389304 @default.
- W2890437514 cites W2014784085 @default.
- W2890437514 cites W2015784299 @default.
- W2890437514 cites W2017462548 @default.
- W2890437514 cites W2019951434 @default.
- W2890437514 cites W2032356038 @default.
- W2890437514 cites W2032864409 @default.
- W2890437514 cites W2034839116 @default.
- W2890437514 cites W2049659815 @default.
- W2890437514 cites W2055056732 @default.
- W2890437514 cites W2063867274 @default.
- W2890437514 cites W2072043218 @default.
- W2890437514 cites W2074773055 @default.
- W2890437514 cites W2095279271 @default.
- W2890437514 cites W2108894171 @default.
- W2890437514 cites W2116210034 @default.
- W2890437514 cites W2124355703 @default.
- W2890437514 cites W2129442068 @default.
- W2890437514 cites W2143077267 @default.
- W2890437514 cites W2156166291 @default.
- W2890437514 cites W2166127057 @default.
- W2890437514 cites W2168008901 @default.
- W2890437514 cites W2314951007 @default.
- W2890437514 cites W2318161819 @default.
- W2890437514 cites W2613253967 @default.
- W2890437514 doi "https://doi.org/10.1177/0267659118766157" @default.
- W2890437514 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/29638199" @default.
- W2890437514 hasPublicationYear "2018" @default.
- W2890437514 type Work @default.
- W2890437514 sameAs 2890437514 @default.
- W2890437514 citedByCount "13" @default.
- W2890437514 countsByYear W28904375142019 @default.
- W2890437514 countsByYear W28904375142020 @default.
- W2890437514 countsByYear W28904375142021 @default.
- W2890437514 countsByYear W28904375142022 @default.
- W2890437514 countsByYear W28904375142023 @default.
- W2890437514 crossrefType "journal-article" @default.
- W2890437514 hasAuthorship W2890437514A5031022861 @default.
- W2890437514 hasAuthorship W2890437514A5034009146 @default.
- W2890437514 hasAuthorship W2890437514A5034595650 @default.
- W2890437514 hasAuthorship W2890437514A5072179089 @default.
- W2890437514 hasAuthorship W2890437514A5083335307 @default.
- W2890437514 hasAuthorship W2890437514A5085108379 @default.
- W2890437514 hasConcept C126322002 @default.
- W2890437514 hasConcept C1621761 @default.
- W2890437514 hasConcept C203014093 @default.
- W2890437514 hasConcept C2777557582 @default.
- W2890437514 hasConcept C2778690821 @default.
- W2890437514 hasConcept C2778881276 @default.
- W2890437514 hasConcept C42219234 @default.
- W2890437514 hasConcept C71924100 @default.
- W2890437514 hasConceptScore W2890437514C126322002 @default.
- W2890437514 hasConceptScore W2890437514C1621761 @default.
- W2890437514 hasConceptScore W2890437514C203014093 @default.
- W2890437514 hasConceptScore W2890437514C2777557582 @default.
- W2890437514 hasConceptScore W2890437514C2778690821 @default.
- W2890437514 hasConceptScore W2890437514C2778881276 @default.
- W2890437514 hasConceptScore W2890437514C42219234 @default.
- W2890437514 hasConceptScore W2890437514C71924100 @default.
- W2890437514 hasIssue "7" @default.
- W2890437514 hasLocation W28904375141 @default.
- W2890437514 hasLocation W28904375142 @default.
- W2890437514 hasOpenAccess W2890437514 @default.
- W2890437514 hasPrimaryLocation W28904375141 @default.
- W2890437514 hasRelatedWork W1813018921 @default.
- W2890437514 hasRelatedWork W1969827477 @default.
- W2890437514 hasRelatedWork W1986651104 @default.
- W2890437514 hasRelatedWork W1993253543 @default.
- W2890437514 hasRelatedWork W2062148306 @default.
- W2890437514 hasRelatedWork W2079475528 @default.
- W2890437514 hasRelatedWork W2084171425 @default.
- W2890437514 hasRelatedWork W2111645375 @default.
- W2890437514 hasRelatedWork W2135218237 @default.
- W2890437514 hasRelatedWork W2144578614 @default.
- W2890437514 hasVolume "33" @default.
- W2890437514 isParatext "false" @default.
- W2890437514 isRetracted "false" @default.
- W2890437514 magId "2890437514" @default.
- W2890437514 workType "article" @default.