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• W2890437692 abstract "Epidemiological studies show that maternal exposure to PM2.5 affects the neurodevelopment of the offspring, especially the neurocognitive function. However, no relevant experimental researches have been published on toxic mechanism and diet intervention. We evaluated the effects of exposure to different doses of PM2.5 on the behavioral development of offspring via a PM2.5 exposure model established by intratracheal instillation, explored its mechanism and the protective effects of quercetin and VC intervention, and focused on the protein expression of CREB/BDNF signaling pathway. Specifically, Exposure to PM2.5 during gestation and lactation period caused maternal oxidative stress. Maternal exposure to PM2.5 changed postnatal open-field behaviors in both gender, impaired spatial learning and memory in the female offspring, increased the level of IL-1β, IL-6, down-regulated p-CREB/CREB, BDNF, TrkB, p-CaMKII/CaMKII, p-CaMKIV/CaMKIV, up-regulated p-Akt/Akt and p-ERK1/2/ERK1/2 in the offspring. In addition, maternal supplementation with quercetin ameliorate the maternal oxidative stress, improved progeny inflammatory response, regulated BDNF, TrkB, p-Akt/Akt, p-ERK1/2/ERK1/2 in female offspring, regulated TrkB, p-CREB/CREB and p-Akt/Akt in male offspring. Maternal supplementation with VC increased the levels of CAT in maternal mice, up-regulated BDNF in female offspring, regulated p-CREB/CREB and p-ERK1/2/ERK1/2 in male offspring. Our findings indicate that PM2.5 exposure during pregnancy and lactation could impair behavioral development of offspring. Quercetin shows more protective effects than VC. The mechanism of neurodevelopmental toxicity induced by PM2.5 may be related to oxidative stress, inflammatory response and modulation of the CREB/BDNF signaling pathway." @default.
• W2890437692 created "2018-09-27" @default.
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• W2890437692 date "2018-12-01" @default.
• W2890437692 modified "2023-10-01" @default.
• W2890437692 title "Neurodevelopmental toxicity induced by maternal PM2.5 exposure and protective effects of quercetin and Vitamin C" @default.
• W2890437692 cites W1166222726 @default.
• W2890437692 cites W1548377685 @default.
• W2890437692 cites W1876835192 @default.
• W2890437692 cites W1903457033 @default.
• W2890437692 cites W1966037459 @default.
• W2890437692 cites W1968241587 @default.
• W2890437692 cites W1970836667 @default.
• W2890437692 cites W1973326832 @default.
• W2890437692 cites W1981827479 @default.
• W2890437692 cites W1987282857 @default.
• W2890437692 cites W1990487655 @default.
• W2890437692 cites W1993099756 @default.
• W2890437692 cites W1994580609 @default.
• W2890437692 cites W1996979240 @default.
• W2890437692 cites W1998052725 @default.
• W2890437692 cites W1998751550 @default.
• W2890437692 cites W2005869604 @default.
• W2890437692 cites W2006376003 @default.
• W2890437692 cites W2008225034 @default.
• W2890437692 cites W2013877398 @default.
• W2890437692 cites W2022392583 @default.
• W2890437692 cites W2023516160 @default.
• W2890437692 cites W2025735078 @default.
• W2890437692 cites W2030398704 @default.
• W2890437692 cites W2035339084 @default.
• W2890437692 cites W2039131669 @default.
• W2890437692 cites W2051928091 @default.
• W2890437692 cites W2059931627 @default.
• W2890437692 cites W2064039790 @default.
• W2890437692 cites W2077555553 @default.
• W2890437692 cites W2088359631 @default.
• W2890437692 cites W2090590228 @default.
• W2890437692 cites W2094775089 @default.
• W2890437692 cites W2100463268 @default.
• W2890437692 cites W2102498068 @default.
• W2890437692 cites W2103235886 @default.
• W2890437692 cites W2112285262 @default.
• W2890437692 cites W2115094443 @default.
• W2890437692 cites W2121873218 @default.
• W2890437692 cites W2126801397 @default.
• W2890437692 cites W2128883244 @default.
• W2890437692 cites W2135919238 @default.
• W2890437692 cites W2136827845 @default.
• W2890437692 cites W2136867910 @default.
• W2890437692 cites W2143210222 @default.
• W2890437692 cites W2151381405 @default.
• W2890437692 cites W2171471584 @default.
• W2890437692 cites W2181531051 @default.
• W2890437692 cites W2186214466 @default.
• W2890437692 cites W2276724985 @default.
• W2890437692 cites W2312659198 @default.
• W2890437692 cites W2337309238 @default.
• W2890437692 cites W2373345807 @default.
• W2890437692 cites W2493905583 @default.
• W2890437692 cites W2500493094 @default.
• W2890437692 cites W2507186816 @default.
• W2890437692 cites W2518947353 @default.
• W2890437692 cites W2531582397 @default.
• W2890437692 cites W2532859617 @default.
• W2890437692 cites W2548978728 @default.
• W2890437692 cites W2552124963 @default.
• W2890437692 cites W2553301009 @default.
• W2890437692 cites W2607350314 @default.
• W2890437692 cites W2620998393 @default.
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• W2890437692 doi "https://doi.org/10.1016/j.chemosphere.2018.09.009" @default.
• W2890437692 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30218877" @default.
• W2890437692 hasPublicationYear "2018" @default.
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