Matches in SemOpenAlex for { <https://semopenalex.org/work/W2890439823> ?p ?o ?g. }
- W2890439823 abstract "With an estimated 390 million infections per year, the four serotypes of dengue virus (DENV) cause the most important mosquito-borne viral disease in humans. The dengue vaccine Dengvaxia was licensed; however, its low efficacy among dengue-naive individuals and increased risk of causing severe dengue in children highlight the need for a better understanding of the role of human antibodies in immunity against DENV. DENV suspensions contain mature, immature, and partially immature particles. We investigated the binding of 22 human monoclonal antibodies (MAbs) to the DENV envelope protein on particles with different maturation states. Potently neutralizing MAbs had higher relative maximum binding and avidity to mature particles than weakly neutralizing MAbs. This was supported by analysis of MAb repertoires and polyclonal sera from patients with primary DENV infection. Together, these findings suggest that mature particles may be the optimal form of presentation of the envelope protein to induce more potent neutralizing antibodies against DENV." @default.
- W2890439823 created "2018-09-27" @default.
- W2890439823 creator A5016628689 @default.
- W2890439823 creator A5024138459 @default.
- W2890439823 creator A5046971682 @default.
- W2890439823 creator A5059959150 @default.
- W2890439823 creator A5065841508 @default.
- W2890439823 creator A5072476030 @default.
- W2890439823 creator A5072557021 @default.
- W2890439823 creator A5081179387 @default.
- W2890439823 creator A5088147193 @default.
- W2890439823 date "2018-12-01" @default.
- W2890439823 modified "2023-10-16" @default.
- W2890439823 title "Potent Neutralizing Human Monoclonal Antibodies Preferentially Target Mature Dengue Virus Particles: Implication for Novel Strategy for Dengue Vaccine" @default.
- W2890439823 cites W1017348960 @default.
- W2890439823 cites W1799716582 @default.
- W2890439823 cites W1885666101 @default.
- W2890439823 cites W1969376060 @default.
- W2890439823 cites W1970455211 @default.
- W2890439823 cites W1978520991 @default.
- W2890439823 cites W1981132160 @default.
- W2890439823 cites W1983305047 @default.
- W2890439823 cites W1989555063 @default.
- W2890439823 cites W2001568055 @default.
- W2890439823 cites W2002545308 @default.
- W2890439823 cites W2005355109 @default.
- W2890439823 cites W2012599139 @default.
- W2890439823 cites W2016266684 @default.
- W2890439823 cites W2017081541 @default.
- W2890439823 cites W2017577931 @default.
- W2890439823 cites W2022037432 @default.
- W2890439823 cites W2029869358 @default.
- W2890439823 cites W2051298245 @default.
- W2890439823 cites W2067389058 @default.
- W2890439823 cites W2068825716 @default.
- W2890439823 cites W2073727854 @default.
- W2890439823 cites W2091001172 @default.
- W2890439823 cites W2094487061 @default.
- W2890439823 cites W2096108215 @default.
- W2890439823 cites W2100572232 @default.
- W2890439823 cites W2106800284 @default.
- W2890439823 cites W2110760542 @default.
- W2890439823 cites W2114296756 @default.
- W2890439823 cites W2121726045 @default.
- W2890439823 cites W2124547357 @default.
- W2890439823 cites W2127324477 @default.
- W2890439823 cites W2131222241 @default.
- W2890439823 cites W2131849805 @default.
- W2890439823 cites W2137755244 @default.
- W2890439823 cites W2138353532 @default.
- W2890439823 cites W2144095627 @default.
- W2890439823 cites W2153930618 @default.
- W2890439823 cites W2155705845 @default.
- W2890439823 cites W2155845482 @default.
- W2890439823 cites W2156864709 @default.
- W2890439823 cites W2171160586 @default.
- W2890439823 cites W2178817171 @default.
- W2890439823 cites W2287622965 @default.
- W2890439823 cites W2494201535 @default.
- W2890439823 cites W2520556610 @default.
- W2890439823 cites W2565673565 @default.
- W2890439823 cites W2617192564 @default.
- W2890439823 cites W2724475480 @default.
- W2890439823 cites W2738629505 @default.
- W2890439823 cites W2755317080 @default.
- W2890439823 cites W4211135732 @default.
- W2890439823 cites W4239275885 @default.
- W2890439823 cites W4361851718 @default.
- W2890439823 cites W762871406 @default.
- W2890439823 doi "https://doi.org/10.1128/jvi.00556-18" @default.
- W2890439823 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6232466" @default.
- W2890439823 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30185598" @default.
- W2890439823 hasPublicationYear "2018" @default.
- W2890439823 type Work @default.
- W2890439823 sameAs 2890439823 @default.
- W2890439823 citedByCount "20" @default.
- W2890439823 countsByYear W28904398232019 @default.
- W2890439823 countsByYear W28904398232020 @default.
- W2890439823 countsByYear W28904398232021 @default.
- W2890439823 countsByYear W28904398232022 @default.
- W2890439823 countsByYear W28904398232023 @default.
- W2890439823 crossrefType "journal-article" @default.
- W2890439823 hasAuthorship W2890439823A5016628689 @default.
- W2890439823 hasAuthorship W2890439823A5024138459 @default.
- W2890439823 hasAuthorship W2890439823A5046971682 @default.
- W2890439823 hasAuthorship W2890439823A5059959150 @default.
- W2890439823 hasAuthorship W2890439823A5065841508 @default.
- W2890439823 hasAuthorship W2890439823A5072476030 @default.
- W2890439823 hasAuthorship W2890439823A5072557021 @default.
- W2890439823 hasAuthorship W2890439823A5081179387 @default.
- W2890439823 hasAuthorship W2890439823A5088147193 @default.
- W2890439823 hasBestOaLocation W28904398231 @default.
- W2890439823 hasConcept C159047783 @default.
- W2890439823 hasConcept C159654299 @default.
- W2890439823 hasConcept C179223381 @default.
- W2890439823 hasConcept C196594336 @default.
- W2890439823 hasConcept C203014093 @default.
- W2890439823 hasConcept C2522874641 @default.
- W2890439823 hasConcept C2779261636 @default.
- W2890439823 hasConcept C2779308166 @default.