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- W2890460904 abstract "Background: Neoadjuvant therapy (NT) is increasingly being used for patients with pancreatic cancer (PDAC). Pretreatment neutrophil lymphocyte ratio (P-NLR) has been shown to predict survival in several cancers including PDAC. We sought to determine the value of P-NLR in predicting response to NT in patients with PDAC. Methods: The prognostic significance of P-NLR (high:>2 vs. low:<2) was evaluated in 70 PDAC patients that received NT. The main endpoint was overall survival (OS) associated with response to NT as measured by the College of American Pathologists (CAP) score (0 = complete pathologic response; 1 = minimal residual cancer/marked response; 2 = residual cancer outgrown by fibrosis/partial response; 3 = extensive residual cancer/poor or no response). Results: Median follow-up time was 22 months. R0 resection margin was achieved in 95% of patients. Compared with low P-NLR, patients with high P-NLR had significantly worse OS (28 vs. 40 months; HR: 2.7, CI: 1.1–6.6, p = 0.03). Patients with CAP scores 0 & 1 had significantly improved OS than those with CAP scores 2 & 3 (69 vs. 44 months; HR: 6.7, CI: 1.6–29.9, p = 0.01). Although high P-NLR patients with CAP score 0 & 1 had improved OS compared with high P-NLR with CAP scores 2 & 3 (72 vs. 34 months, p = 0.003; HR 0.1, CI: 0.03–0.62), there was no difference in OS in low P-NLR patients with CAP scores 0 & 1 vs 2 & 3 (71 vs. 59 months, p = 0.89, HR 1.1, CI: 0.21–6.17). Conclusion: While low P-NLR group had better survival than high P-NLR, only high P-NLR group showed survival benefit with neoadjuvant chemotherapy pathological response. Further studies needed to confirm the above in a larger sample." @default.
- W2890460904 created "2018-09-27" @default.
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- W2890460904 date "2018-03-01" @default.
- W2890460904 modified "2023-10-16" @default.
- W2890460904 title "The role of pretreatment neutrophil/lymphocyte ratio in predicting survival in pancreatic cancer patients based on neoadjuvant chemotherapy pathological response" @default.
- W2890460904 doi "https://doi.org/10.1016/j.hpb.2018.02.235" @default.
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