FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2890461213> ?p ?o ?g. }

• W2890461213 endingPage "1223" @default.
• W2890461213 startingPage "1214" @default.
• W2890461213 abstract "The endoplasmic reticulum (ER) is an architecturally diverse organelle that serves as a membrane source for the replication of multiple viruses. Flaviviruses, including yellow fever virus, West Nile virus, dengue virus and Zika virus, induce unique single-membrane ER invaginations that house the viral replication machinery1. Whether this virus-induced ER remodelling is vulnerable to antiviral pathways is unknown. Here, we show that flavivirus replication at the ER is targeted by the interferon (IFN) response. Through genome-scale CRISPR screening, we uncovered an antiviral mechanism mediated by a functional gene pairing between IFI6 (encoding IFN-α-inducible protein 6), an IFN-stimulated gene cloned over 30 years ago2, and HSPA5, which encodes the ER-resident heat shock protein 70 chaperone BiP. We reveal that IFI6 is an ER-localized integral membrane effector that is stabilized through interactions with BiP. Mechanistically, IFI6 prophylactically protects uninfected cells by preventing the formation of virus-induced ER membrane invaginations. Notably, IFI6 has little effect on other mammalian RNA viruses, including the related Flaviviridae family member hepatitis C virus, which replicates in double-membrane vesicles that protrude outwards from the ER. These findings support a model in which the IFN response is armed with a membrane-targeted effector that discriminately blocks the establishment of virus-specific ER microenvironments that are required for replication." @default.
• W2890461213 created "2018-09-27" @default.
• W2890461213 creator A5017016861 @default.
• W2890461213 creator A5018664498 @default.
• W2890461213 creator A5023697572 @default.
• W2890461213 creator A5023840226 @default.
• W2890461213 creator A5028162368 @default.
• W2890461213 creator A5043316539 @default.
• W2890461213 creator A5046165271 @default.
• W2890461213 creator A5046194366 @default.
• W2890461213 creator A5065057086 @default.
• W2890461213 creator A5067225314 @default.
• W2890461213 creator A5074403433 @default.
• W2890461213 creator A5087524000 @default.
• W2890461213 date "2018-09-17" @default.
• W2890461213 modified "2023-10-16" @default.
• W2890461213 title "A CRISPR screen identifies IFI6 as an ER-resident interferon effector that blocks flavivirus replication" @default.
• W2890461213 cites W1489272761 @default.
• W2890461213 cites W1584086642 @default.
• W2890461213 cites W1622488271 @default.
• W2890461213 cites W1971214320 @default.
• W2890461213 cites W1973260880 @default.
• W2890461213 cites W1998770647 @default.
• W2890461213 cites W2012156061 @default.
• W2890461213 cites W2018637841 @default.
• W2890461213 cites W2024970900 @default.
• W2890461213 cites W2029052029 @default.
• W2890461213 cites W2030925771 @default.
• W2890461213 cites W2031211461 @default.
• W2890461213 cites W2035826838 @default.
• W2890461213 cites W2041758725 @default.
• W2890461213 cites W2051956247 @default.
• W2890461213 cites W2058277625 @default.
• W2890461213 cites W2059226699 @default.
• W2890461213 cites W2066845132 @default.
• W2890461213 cites W2078646756 @default.
• W2890461213 cites W2084604444 @default.
• W2890461213 cites W2085202049 @default.
• W2890461213 cites W2089640290 @default.
• W2890461213 cites W2100122648 @default.
• W2890461213 cites W2101575257 @default.
• W2890461213 cites W2112330012 @default.
• W2890461213 cites W2115259452 @default.
• W2890461213 cites W2115425661 @default.
• W2890461213 cites W2118830863 @default.
• W2890461213 cites W2128517237 @default.
• W2890461213 cites W2131242974 @default.
• W2890461213 cites W2160107586 @default.
• W2890461213 cites W2228347275 @default.
• W2890461213 cites W2413814731 @default.
• W2890461213 cites W2426204902 @default.
• W2890461213 cites W2522122580 @default.
• W2890461213 cites W2526388434 @default.
• W2890461213 cites W2567416137 @default.
• W2890461213 cites W2584795971 @default.
• W2890461213 cites W2593410784 @default.
• W2890461213 cites W2793366365 @default.
• W2890461213 doi "https://doi.org/10.1038/s41564-018-0244-1" @default.
• W2890461213 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6202210" @default.
• W2890461213 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30224801" @default.
• W2890461213 hasPublicationYear "2018" @default.
• W2890461213 type Work @default.
• W2890461213 sameAs 2890461213 @default.
• W2890461213 citedByCount "112" @default.
• W2890461213 countsByYear W28904612132019 @default.
• W2890461213 countsByYear W28904612132020 @default.
• W2890461213 countsByYear W28904612132021 @default.
• W2890461213 countsByYear W28904612132022 @default.
• W2890461213 countsByYear W28904612132023 @default.
• W2890461213 crossrefType "journal-article" @default.
• W2890461213 hasAuthorship W2890461213A5017016861 @default.
• W2890461213 hasAuthorship W2890461213A5018664498 @default.
• W2890461213 hasAuthorship W2890461213A5023697572 @default.
• W2890461213 hasAuthorship W2890461213A5023840226 @default.
• W2890461213 hasAuthorship W2890461213A5028162368 @default.
• W2890461213 hasAuthorship W2890461213A5043316539 @default.
• W2890461213 hasAuthorship W2890461213A5046165271 @default.
• W2890461213 hasAuthorship W2890461213A5046194366 @default.
• W2890461213 hasAuthorship W2890461213A5065057086 @default.
• W2890461213 hasAuthorship W2890461213A5067225314 @default.
• W2890461213 hasAuthorship W2890461213A5074403433 @default.
• W2890461213 hasAuthorship W2890461213A5087524000 @default.
• W2890461213 hasBestOaLocation W28904612131 @default.
• W2890461213 hasConcept C104317684 @default.
• W2890461213 hasConcept C140704245 @default.
• W2890461213 hasConcept C158617107 @default.
• W2890461213 hasConcept C159047783 @default.
• W2890461213 hasConcept C2522874641 @default.
• W2890461213 hasConcept C2776178377 @default.
• W2890461213 hasConcept C2776408679 @default.
• W2890461213 hasConcept C2777510210 @default.
• W2890461213 hasConcept C2779635636 @default.
• W2890461213 hasConcept C2780568436 @default.
• W2890461213 hasConcept C51785407 @default.
• W2890461213 hasConcept C54355233 @default.
• W2890461213 hasConcept C86803240 @default.
• W2890461213 hasConcept C95444343 @default.
• W2890461213 hasConcept C98108389 @default.

• next