FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2890466817> ?p ?o ?g. }

• W2890466817 abstract "Introduction: Malignant pleural mesothelioma (MPM) is a malignancy with a very poor prognosis for which new treatment options are urgently needed. We have previously shown that dendritic cell (DC) immunotherapy provides a clinically feasible treatment option. In the current study, we set out to assess the immunological changes induced by DC immunotherapy in peripheral blood of MPM patients. Methods: Peripheral blood was collected from nine patients enrolled in a phase I dose escalation study, before and after treatment with DCs that were pulsed with an allogeneic tumor lysate preparation consisting of a mixture of five cultured mesothelioma cell lines. We used immune profiling by multiplex flow cytometry to characterize different populations of immune cells. In particular, we determined frequencies of T cell subsets that showed single and combinatorial expression of multiple markers that signify T cell activation, maturation and inhibition. Therapy-induced T cell reactivity was assessed in peptide/MHC multimer stainings using mesothelin as a prototypic target antigen with confirmed expression in the clinical tumor lysate preparation. T cell receptor (TCR) diversity was evaluated by TCR-Vbeta PCR assays. Results: We observed an increase in the numbers of B cells, CD4 and CD8 T cells, but not NK cells at 6 weeks post treatment. The increases in B and T lymphocytes were not accompanied by major changes in T cell reactivity towards mesothelin nor in TCRB diversity. Notably, we did observe enhanced proportions of CD4 T cells expressing HLA-DR, PD-1 (at 2 weeks after onset of treatment) and ICOS (6 weeks) and a CD8 T cell population expressing LAG3 (2 weeks). Discussion: DC immunotherapy using allogeneic tumor lysate resulted in enhanced frequencies of B cells and T cells in blood. We did not detect a skewed antigen-reactivity of peripheral CD8 T cells. Interestingly, frequencies of CD4 T cells expressing activation markers and PD-1 were increased. These findings indicate a systemic activation of the adaptive immune response and may guide future immune monitoring studies of DC therapies." @default.
• W2890466817 created "2018-09-27" @default.
• W2890466817 creator A5012937808 @default.
• W2890466817 creator A5020254778 @default.
• W2890466817 creator A5022214407 @default.
• W2890466817 creator A5031007260 @default.
• W2890466817 creator A5038380886 @default.
• W2890466817 creator A5040016234 @default.
• W2890466817 creator A5051066209 @default.
• W2890466817 creator A5069775632 @default.
• W2890466817 creator A5076709979 @default.
• W2890466817 creator A5080628121 @default.
• W2890466817 date "2018-09-07" @default.
• W2890466817 modified "2023-09-25" @default.
• W2890466817 title "Autologous Dendritic Cell Therapy in Mesothelioma Patients Enhances Frequencies of Peripheral CD4 T Cells Expressing HLA-DR, PD-1, or ICOS" @default.
• W2890466817 cites W1538763181 @default.
• W2890466817 cites W1594591001 @default.
• W2890466817 cites W1661441964 @default.
• W2890466817 cites W1965668880 @default.
• W2890466817 cites W1995970041 @default.
• W2890466817 cites W2007026865 @default.
• W2890466817 cites W2020094108 @default.
• W2890466817 cites W2049126749 @default.
• W2890466817 cites W2052062569 @default.
• W2890466817 cites W2053067769 @default.
• W2890466817 cites W2057187391 @default.
• W2890466817 cites W2068323100 @default.
• W2890466817 cites W2101327682 @default.
• W2890466817 cites W2106775454 @default.
• W2890466817 cites W2112407455 @default.
• W2890466817 cites W2128113360 @default.
• W2890466817 cites W2130185552 @default.
• W2890466817 cites W2141745968 @default.
• W2890466817 cites W2144517053 @default.
• W2890466817 cites W2144995154 @default.
• W2890466817 cites W2149382500 @default.
• W2890466817 cites W2155101465 @default.
• W2890466817 cites W2157041114 @default.
• W2890466817 cites W2168685265 @default.
• W2890466817 cites W2208013529 @default.
• W2890466817 cites W2219230917 @default.
• W2890466817 cites W2274387391 @default.
• W2890466817 cites W2512308427 @default.
• W2890466817 cites W2594793697 @default.
• W2890466817 cites W2739145658 @default.
• W2890466817 cites W2772809021 @default.
• W2890466817 doi "https://doi.org/10.3389/fimmu.2018.02034" @default.
• W2890466817 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6137618" @default.
• W2890466817 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30245692" @default.
• W2890466817 hasPublicationYear "2018" @default.
• W2890466817 type Work @default.
• W2890466817 sameAs 2890466817 @default.
• W2890466817 citedByCount "10" @default.
• W2890466817 countsByYear W28904668172019 @default.
• W2890466817 countsByYear W28904668172020 @default.
• W2890466817 countsByYear W28904668172021 @default.
• W2890466817 countsByYear W28904668172022 @default.
• W2890466817 countsByYear W28904668172023 @default.
• W2890466817 crossrefType "journal-article" @default.
• W2890466817 hasAuthorship W2890466817A5012937808 @default.
• W2890466817 hasAuthorship W2890466817A5020254778 @default.
• W2890466817 hasAuthorship W2890466817A5022214407 @default.
• W2890466817 hasAuthorship W2890466817A5031007260 @default.
• W2890466817 hasAuthorship W2890466817A5038380886 @default.
• W2890466817 hasAuthorship W2890466817A5040016234 @default.
• W2890466817 hasAuthorship W2890466817A5051066209 @default.
• W2890466817 hasAuthorship W2890466817A5069775632 @default.
• W2890466817 hasAuthorship W2890466817A5076709979 @default.
• W2890466817 hasAuthorship W2890466817A5080628121 @default.
• W2890466817 hasBestOaLocation W28904668171 @default.
• W2890466817 hasConcept C147483822 @default.
• W2890466817 hasConcept C154317977 @default.
• W2890466817 hasConcept C167672396 @default.
• W2890466817 hasConcept C188280979 @default.
• W2890466817 hasConcept C19317047 @default.
• W2890466817 hasConcept C202751555 @default.
• W2890466817 hasConcept C203014093 @default.
• W2890466817 hasConcept C2776090121 @default.
• W2890466817 hasConcept C2777045440 @default.
• W2890466817 hasConcept C2777701055 @default.
• W2890466817 hasConcept C502942594 @default.
• W2890466817 hasConcept C553184892 @default.
• W2890466817 hasConcept C55493867 @default.
• W2890466817 hasConcept C71924100 @default.
• W2890466817 hasConcept C86803240 @default.
• W2890466817 hasConcept C8891405 @default.
• W2890466817 hasConceptScore W2890466817C147483822 @default.
• W2890466817 hasConceptScore W2890466817C154317977 @default.
• W2890466817 hasConceptScore W2890466817C167672396 @default.
• W2890466817 hasConceptScore W2890466817C188280979 @default.
• W2890466817 hasConceptScore W2890466817C19317047 @default.
• W2890466817 hasConceptScore W2890466817C202751555 @default.
• W2890466817 hasConceptScore W2890466817C203014093 @default.
• W2890466817 hasConceptScore W2890466817C2776090121 @default.
• W2890466817 hasConceptScore W2890466817C2777045440 @default.
• W2890466817 hasConceptScore W2890466817C2777701055 @default.
• W2890466817 hasConceptScore W2890466817C502942594 @default.
• W2890466817 hasConceptScore W2890466817C553184892 @default.
• W2890466817 hasConceptScore W2890466817C55493867 @default.
• W2890466817 hasConceptScore W2890466817C71924100 @default.

• next