FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2890475160> ?p ?o ?g. }

• W2890475160 abstract "When obesity is caused by consumption of a high-fat diet, the tumor suppressor pRb is phosphoinactivated in the neurons of the mediobasal hypothalamus, a brain area critical for energy-balance regulation. However, the functional relevance of pRb phosphoinactivation in the mediobasal hypothalamus to diet-induced obesity remains unknown. Here, we show that inhibiting pRb phosphorylation in the mediobasal hypothalamus can prevent and treat diet-induced obesity in mice. Expressing an unphosphorylable pRb nonselectively in the mediobasal hypothalamus or conditionally in anorexigenic POMC neurons inhibits diet-induced obesity. Intracerebroventricular delivery of US Food and Drug Administration-approved (FDA-approved) cyclin-dependent kinase 4 (CDK4) inhibitor abemaciclib inhibits pRb phosphorylation in the mediobasal hypothalamus and prevents diet-induced obesity. Oral administration of abemaciclib at doses approved for human use reduces fat mass in diet-induced obese mice by increasing lipid oxidation without significantly reducing lean mass. With analysis of recent literature identifying CDK4 as the most abundantly expressed neuronal CDK in the mediobasal hypothalamus, our work uncovers CDK4 as the major kinase for hypothalamic pRb phosphoinactivation and a highly effective central antiobesity target. As three CDK4/6 inhibitors have recently received FDA approval for life-long breast cancer therapy, our study provides a preclinical basis for their expedient repurposing for obesity management." @default.
• W2890475160 created "2018-09-27" @default.
• W2890475160 creator A5017567018 @default.
• W2890475160 creator A5021490701 @default.
• W2890475160 creator A5044062128 @default.
• W2890475160 creator A5056122201 @default.
• W2890475160 creator A5066893639 @default.
• W2890475160 creator A5087741712 @default.
• W2890475160 date "2018-09-06" @default.
• W2890475160 modified "2023-09-23" @default.
• W2890475160 title "Cyclin-dependent kinase 4 is a preclinical target for diet-induced obesity" @default.
• W2890475160 cites W1539401343 @default.
• W2890475160 cites W1976555898 @default.
• W2890475160 cites W1981842016 @default.
• W2890475160 cites W1982249980 @default.
• W2890475160 cites W1984548515 @default.
• W2890475160 cites W1985956159 @default.
• W2890475160 cites W1988198379 @default.
• W2890475160 cites W1997312032 @default.
• W2890475160 cites W2009428120 @default.
• W2890475160 cites W2011129440 @default.
• W2890475160 cites W2014345877 @default.
• W2890475160 cites W2024814110 @default.
• W2890475160 cites W2035032297 @default.
• W2890475160 cites W2036861129 @default.
• W2890475160 cites W2039749588 @default.
• W2890475160 cites W2042893069 @default.
• W2890475160 cites W2049507532 @default.
• W2890475160 cites W2051981831 @default.
• W2890475160 cites W2069072617 @default.
• W2890475160 cites W2078605292 @default.
• W2890475160 cites W2079117146 @default.
• W2890475160 cites W2080748945 @default.
• W2890475160 cites W2102992960 @default.
• W2890475160 cites W2109590963 @default.
• W2890475160 cites W2109627278 @default.
• W2890475160 cites W2110865130 @default.
• W2890475160 cites W2112451262 @default.
• W2890475160 cites W2120709000 @default.
• W2890475160 cites W2128721675 @default.
• W2890475160 cites W2134511984 @default.
• W2890475160 cites W2144690367 @default.
• W2890475160 cites W2145130242 @default.
• W2890475160 cites W2151566924 @default.
• W2890475160 cites W2156796753 @default.
• W2890475160 cites W2169342042 @default.
• W2890475160 cites W2169612876 @default.
• W2890475160 cites W2219817965 @default.
• W2890475160 cites W2402797587 @default.
• W2890475160 cites W2469199053 @default.
• W2890475160 cites W2475269618 @default.
• W2890475160 cites W2497075302 @default.
• W2890475160 cites W2586421092 @default.
• W2890475160 cites W2588550986 @default.
• W2890475160 cites W2772178670 @default.
• W2890475160 cites W2790280442 @default.
• W2890475160 cites W345803373 @default.
• W2890475160 doi "https://doi.org/10.1172/jci.insight.123000" @default.
• W2890475160 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6171799" @default.
• W2890475160 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30185666" @default.
• W2890475160 hasPublicationYear "2018" @default.
• W2890475160 type Work @default.
• W2890475160 sameAs 2890475160 @default.
• W2890475160 citedByCount "13" @default.
• W2890475160 countsByYear W28904751602019 @default.
• W2890475160 countsByYear W28904751602020 @default.
• W2890475160 countsByYear W28904751602021 @default.
• W2890475160 countsByYear W28904751602022 @default.
• W2890475160 countsByYear W28904751602023 @default.
• W2890475160 crossrefType "journal-article" @default.
• W2890475160 hasAuthorship W2890475160A5017567018 @default.
• W2890475160 hasAuthorship W2890475160A5021490701 @default.
• W2890475160 hasAuthorship W2890475160A5044062128 @default.
• W2890475160 hasAuthorship W2890475160A5056122201 @default.
• W2890475160 hasAuthorship W2890475160A5066893639 @default.
• W2890475160 hasAuthorship W2890475160A5087741712 @default.
• W2890475160 hasBestOaLocation W28904751601 @default.
• W2890475160 hasConcept C126322002 @default.
• W2890475160 hasConcept C134018914 @default.
• W2890475160 hasConcept C184235292 @default.
• W2890475160 hasConcept C2777003273 @default.
• W2890475160 hasConcept C502942594 @default.
• W2890475160 hasConcept C511355011 @default.
• W2890475160 hasConcept C71924100 @default.
• W2890475160 hasConcept C86803240 @default.
• W2890475160 hasConcept C95444343 @default.
• W2890475160 hasConceptScore W2890475160C126322002 @default.
• W2890475160 hasConceptScore W2890475160C134018914 @default.
• W2890475160 hasConceptScore W2890475160C184235292 @default.
• W2890475160 hasConceptScore W2890475160C2777003273 @default.
• W2890475160 hasConceptScore W2890475160C502942594 @default.
• W2890475160 hasConceptScore W2890475160C511355011 @default.
• W2890475160 hasConceptScore W2890475160C71924100 @default.
• W2890475160 hasConceptScore W2890475160C86803240 @default.
• W2890475160 hasConceptScore W2890475160C95444343 @default.
• W2890475160 hasIssue "17" @default.
• W2890475160 hasLocation W28904751601 @default.
• W2890475160 hasLocation W28904751602 @default.
• W2890475160 hasLocation W28904751603 @default.
• W2890475160 hasLocation W28904751604 @default.

• next