FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2890477831> ?p ?o ?g. }

• W2890477831 endingPage "2161" @default.
• W2890477831 startingPage "2151" @default.
• W2890477831 abstract "The molecular chaperones are central mediators of protein homeostasis. In that role, they engage in widespread protein-protein interactions (PPIs) with each other and with their client proteins. Together, these PPIs form the backbone of a network that ensures proper vigilance over the processes of protein folding, trafficking, quality control, and degradation. The core chaperones, such as the heat shock proteins Hsp60, Hsp70, and Hsp90, are widely expressed in most tissues, yet there is growing evidence that the PPIs among them may be re-wired in disease conditions. This possibility suggests that these PPIs, and perhaps not the individual chaperones themselves, could be compelling drug targets. Indeed, recent efforts have yielded small molecules that inhibit (or promote) a subset of inter-chaperone PPIs. These chemical probes are being used to study chaperone networks in a range of models, and the successes with these approaches have inspired a community-wide objective to produce inhibitors for a broader set of targets. In this Review, we discuss progress toward that goal and point out some of the challenges ahead." @default.
• W2890477831 created "2018-09-27" @default.
• W2890477831 creator A5040066574 @default.
• W2890477831 creator A5067529915 @default.
• W2890477831 date "2019-02-01" @default.
• W2890477831 modified "2023-10-17" @default.
• W2890477831 title "Inhibitors and chemical probes for molecular chaperone networks" @default.
• W2890477831 cites W1763254533 @default.
• W2890477831 cites W1868485901 @default.
• W2890477831 cites W1965253007 @default.
• W2890477831 cites W1966122416 @default.
• W2890477831 cites W1966935234 @default.
• W2890477831 cites W1970460458 @default.
• W2890477831 cites W1971108880 @default.
• W2890477831 cites W1972121275 @default.
• W2890477831 cites W1973765041 @default.
• W2890477831 cites W1976220825 @default.
• W2890477831 cites W1980505864 @default.
• W2890477831 cites W1981988682 @default.
• W2890477831 cites W1993549724 @default.
• W2890477831 cites W1996023567 @default.
• W2890477831 cites W1997670933 @default.
• W2890477831 cites W1998259550 @default.
• W2890477831 cites W2001569984 @default.
• W2890477831 cites W2005459694 @default.
• W2890477831 cites W2007103196 @default.
• W2890477831 cites W2008441315 @default.
• W2890477831 cites W2014839850 @default.
• W2890477831 cites W2016976719 @default.
• W2890477831 cites W2019866589 @default.
• W2890477831 cites W2020742237 @default.
• W2890477831 cites W2021040301 @default.
• W2890477831 cites W2021730076 @default.
• W2890477831 cites W2022294369 @default.
• W2890477831 cites W2025623674 @default.
• W2890477831 cites W2025635334 @default.
• W2890477831 cites W2026771902 @default.
• W2890477831 cites W2027844138 @default.
• W2890477831 cites W2031329821 @default.
• W2890477831 cites W2032313009 @default.
• W2890477831 cites W2034086354 @default.
• W2890477831 cites W2036604732 @default.
• W2890477831 cites W2038016070 @default.
• W2890477831 cites W2045033562 @default.
• W2890477831 cites W2049631853 @default.
• W2890477831 cites W2051540705 @default.
• W2890477831 cites W2052151051 @default.
• W2890477831 cites W2052697091 @default.
• W2890477831 cites W2054290614 @default.
• W2890477831 cites W2075239233 @default.
• W2890477831 cites W2077004593 @default.
• W2890477831 cites W2078741614 @default.
• W2890477831 cites W2080409112 @default.
• W2890477831 cites W2082140468 @default.
• W2890477831 cites W2082862625 @default.
• W2890477831 cites W2087689873 @default.
• W2890477831 cites W2089206488 @default.
• W2890477831 cites W2089400513 @default.
• W2890477831 cites W2089558579 @default.
• W2890477831 cites W2091492589 @default.
• W2890477831 cites W2094753632 @default.
• W2890477831 cites W2095231417 @default.
• W2890477831 cites W2095722179 @default.
• W2890477831 cites W2095763971 @default.
• W2890477831 cites W2096038757 @default.
• W2890477831 cites W2100881236 @default.
• W2890477831 cites W2102049218 @default.
• W2890477831 cites W2104935252 @default.
• W2890477831 cites W2109936231 @default.
• W2890477831 cites W2112232744 @default.
• W2890477831 cites W2112374700 @default.
• W2890477831 cites W2113234217 @default.
• W2890477831 cites W2140432698 @default.
• W2890477831 cites W2143633033 @default.
• W2890477831 cites W2148065722 @default.
• W2890477831 cites W2149436095 @default.
• W2890477831 cites W2154654162 @default.
• W2890477831 cites W2156576736 @default.
• W2890477831 cites W2156739666 @default.
• W2890477831 cites W2160269498 @default.
• W2890477831 cites W2160577276 @default.
• W2890477831 cites W2160690759 @default.
• W2890477831 cites W2161577974 @default.
• W2890477831 cites W2162483267 @default.
• W2890477831 cites W2163739062 @default.
• W2890477831 cites W2167398093 @default.
• W2890477831 cites W2191152768 @default.
• W2890477831 cites W2238888716 @default.
• W2890477831 cites W2254771353 @default.
• W2890477831 cites W2263525143 @default.
• W2890477831 cites W2274015824 @default.
• W2890477831 cites W2280676615 @default.
• W2890477831 cites W2293815880 @default.
• W2890477831 cites W2319153280 @default.
• W2890477831 cites W2334168507 @default.
• W2890477831 cites W2335222230 @default.
• W2890477831 cites W2338903889 @default.
• W2890477831 cites W2344331730 @default.

• next