FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2890499780> ?p ?o ?g. }

• W2890499780 endingPage "443" @default.
• W2890499780 startingPage "434" @default.
• W2890499780 abstract "Pitavastatin inhibits 3 hydroxy 3 methyl glutaryl coenzyme A (HMGCoA) reductase enzyme, preventing cholesterol synthesis along with elevating high density apolipoprotein A1 (Apo-A1). The present study was designed to evaluate cardioprotective potential of pitavastatin at 1 mg/kg/day and 3 mg/kg/day dose for 14 days in low dose isoproterenol (ISO) (5 mg/kg/day for 7 consecutive days) induced myocardial damage. ISO administration induced significant reduction in endogenous antioxidant enzymes like reduced glutathione (GSH), superoxide dismutase (SOD), catalase (CAT) and raised thiobarbituric acid reactive substances (TBARS) indicating activated lipid peroxidation. Along with this, a significant increase in level of cardiac injury biomarkers vie, creatine kinase (CK-MB), lactate dehydrogenase (LDH), aspartate amino transferase (AST), tumor necrosis factor (TNF-α) and transforming growth factor (TGF-β) as well as brain natriuretic peptide (BNP). Histological examination also revealed marked myocardial tissue damage in ISO treated rats. However, pretreatment with pitavastatin (3 mg/kg/day) significantly maintained nearly normal levels of cardiac biomarkers and oxidant antioxidant status as well as lipid peroxidation in ISO induced MI rats. Cardiac histological assessment and infarct size assessment also showed marked reduction in myocardial architecture alteration including infarct size as well as collagen deposition by pitavastatin that strongly supported biochemical findings. These observations strongly corroborate that pitavastatin prevents myocardial damages via up regulation of endogenous oxidants along with its hypocholesterolemic activity." @default.
• W2890499780 created "2018-09-27" @default.
• W2890499780 creator A5013569767 @default.
• W2890499780 creator A5023024286 @default.
• W2890499780 creator A5027630088 @default.
• W2890499780 creator A5043642432 @default.
• W2890499780 creator A5086714442 @default.
• W2890499780 creator A5087230626 @default.
• W2890499780 date "2018-09-07" @default.
• W2890499780 modified "2023-10-16" @default.
• W2890499780 title "Pitavastatin ameliorates myocardial damage by preventing inflammation and collagen deposition via reduced free radical generation in isoproterenol-induced cardiomyopathy" @default.
• W2890499780 cites W115120425 @default.
• W2890499780 cites W1603502910 @default.
• W2890499780 cites W1775749144 @default.
• W2890499780 cites W1826355858 @default.
• W2890499780 cites W1978152747 @default.
• W2890499780 cites W1981797363 @default.
• W2890499780 cites W2004844858 @default.
• W2890499780 cites W2008576439 @default.
• W2890499780 cites W2014555432 @default.
• W2890499780 cites W2023419517 @default.
• W2890499780 cites W2024911951 @default.
• W2890499780 cites W2029654767 @default.
• W2890499780 cites W2030155718 @default.
• W2890499780 cites W2041688157 @default.
• W2890499780 cites W2041755731 @default.
• W2890499780 cites W2042087846 @default.
• W2890499780 cites W2052558573 @default.
• W2890499780 cites W2056530140 @default.
• W2890499780 cites W2060340186 @default.
• W2890499780 cites W2063576996 @default.
• W2890499780 cites W2065232390 @default.
• W2890499780 cites W2078757411 @default.
• W2890499780 cites W2081182791 @default.
• W2890499780 cites W2088866343 @default.
• W2890499780 cites W2089405687 @default.
• W2890499780 cites W2098643301 @default.
• W2890499780 cites W2104969714 @default.
• W2890499780 cites W2125311258 @default.
• W2890499780 cites W2126251788 @default.
• W2890499780 cites W2131056473 @default.
• W2890499780 cites W2136718447 @default.
• W2890499780 cites W2146409845 @default.
• W2890499780 cites W2157245535 @default.
• W2890499780 cites W2164089346 @default.
• W2890499780 cites W2196906371 @default.
• W2890499780 cites W2263023695 @default.
• W2890499780 cites W2273081455 @default.
• W2890499780 cites W2317242663 @default.
• W2890499780 cites W2324186239 @default.
• W2890499780 cites W2557012249 @default.
• W2890499780 cites W2581927139 @default.
• W2890499780 cites W2613852168 @default.
• W2890499780 cites W2631317507 @default.
• W2890499780 cites W3022864527 @default.
• W2890499780 cites W4254424778 @default.
• W2890499780 cites W4292856638 @default.
• W2890499780 doi "https://doi.org/10.1080/10641963.2018.1501059" @default.
• W2890499780 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30192645" @default.
• W2890499780 hasPublicationYear "2018" @default.
• W2890499780 type Work @default.
• W2890499780 sameAs 2890499780 @default.
• W2890499780 citedByCount "8" @default.
• W2890499780 countsByYear W28904997802019 @default.
• W2890499780 countsByYear W28904997802020 @default.
• W2890499780 countsByYear W28904997802021 @default.
• W2890499780 countsByYear W28904997802022 @default.
• W2890499780 countsByYear W28904997802023 @default.
• W2890499780 crossrefType "journal-article" @default.
• W2890499780 hasAuthorship W2890499780A5013569767 @default.
• W2890499780 hasAuthorship W2890499780A5023024286 @default.
• W2890499780 hasAuthorship W2890499780A5027630088 @default.
• W2890499780 hasAuthorship W2890499780A5043642432 @default.
• W2890499780 hasAuthorship W2890499780A5086714442 @default.
• W2890499780 hasAuthorship W2890499780A5087230626 @default.
• W2890499780 hasConcept C126322002 @default.
• W2890499780 hasConcept C134018914 @default.
• W2890499780 hasConcept C181199279 @default.
• W2890499780 hasConcept C185592680 @default.
• W2890499780 hasConcept C2775838275 @default.
• W2890499780 hasConcept C2776151105 @default.
• W2890499780 hasConcept C2776692505 @default.
• W2890499780 hasConcept C2776839432 @default.
• W2890499780 hasConcept C2777318727 @default.
• W2890499780 hasConcept C2777352226 @default.
• W2890499780 hasConcept C2777504301 @default.
• W2890499780 hasConcept C2778004101 @default.
• W2890499780 hasConcept C2778532138 @default.
• W2890499780 hasConcept C2780829032 @default.
• W2890499780 hasConcept C36036425 @default.
• W2890499780 hasConcept C500558357 @default.
• W2890499780 hasConcept C538909803 @default.
• W2890499780 hasConcept C55493867 @default.
• W2890499780 hasConcept C71924100 @default.
• W2890499780 hasConcept C98274493 @default.
• W2890499780 hasConceptScore W2890499780C126322002 @default.
• W2890499780 hasConceptScore W2890499780C134018914 @default.
• W2890499780 hasConceptScore W2890499780C181199279 @default.

• next