FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2890500897> ?p ?o ?g. }

• W2890500897 endingPage "e0203955" @default.
• W2890500897 startingPage "e0203955" @default.
• W2890500897 abstract "Nitric oxide (NO) can be generated from nitrite by reductase activity of deoxygenated hemoglobin (deoxyHb) apparently to facilitate tissue perfusion under hypoxic condition. Although hemoglobin E (HbE) solutions have been shown to exhibit decreased rate of nitrite reduction to NO, this observation has never been reported in erythrocytes from subjects with hemoglobin E/ß-thalassemia (HbE/ß-thal). In this study, we investigated the nitrite reductase activity of deoxyHb dialysates from 58 non-splenectomized and 23 splenectomized HbE/ß-thal subjects compared to 47 age- and sex-matched normal subjects, and examined its correlation with platelet activity. Iron-nitrosyl-hemoglobin (HbNO) was measured by tri-iodide reductive chemiluminescence as a marker of NO generation. HbNO produced from the reaction of nitrite with deoxyHb dialysate from both non-splenectomized and splenectomized HbE/ß-thal subjects was lower than that of normal (AA) hemoglobin subjects. P-selectin expression, a marker of platelet activation, at baseline and in reactivity to stimulation by adenosine diphosphate (ADP), were higher in HbE/ß-thal subjects than normal subjects. HbNO formation from the reactions of nitrite and deoxyHb inversely correlated with baseline platelet P-selectin expression, HbE levels, and tricuspid regurgitant velocity (TRV). Nitrite plus deoxygenated erythrocytes from HbE/ß-thal subjects had a lower ability to inhibit ADP-induced P-selectin expression on platelets than erythrocytes from normal subjects. We conclude that deoxyHb in erythrocytes from HbE/ß-thal subjects has a decreased ability to reduce nitrite to NO, which is correlated with increased platelet activity in these individuals." @default.
• W2890500897 created "2018-09-27" @default.
• W2890500897 creator A5013226401 @default.
• W2890500897 creator A5027950965 @default.
• W2890500897 creator A5028075577 @default.
• W2890500897 creator A5032976426 @default.
• W2890500897 creator A5039568106 @default.
• W2890500897 creator A5047048178 @default.
• W2890500897 creator A5054182018 @default.
• W2890500897 creator A5054330291 @default.
• W2890500897 creator A5079028675 @default.
• W2890500897 date "2018-09-20" @default.
• W2890500897 modified "2023-10-12" @default.
• W2890500897 title "Decreased nitrite reductase activity of deoxyhemoglobin correlates with platelet activation in hemoglobin E/ß-thalassemia subjects" @default.
• W2890500897 cites W137633485 @default.
• W2890500897 cites W1589586351 @default.
• W2890500897 cites W169337690 @default.
• W2890500897 cites W1994748657 @default.
• W2890500897 cites W200405971 @default.
• W2890500897 cites W2005061205 @default.
• W2890500897 cites W2005466083 @default.
• W2890500897 cites W2011640462 @default.
• W2890500897 cites W2012154760 @default.
• W2890500897 cites W2013392029 @default.
• W2890500897 cites W2016139728 @default.
• W2890500897 cites W2017470603 @default.
• W2890500897 cites W2024514051 @default.
• W2890500897 cites W2026086821 @default.
• W2890500897 cites W2026117623 @default.
• W2890500897 cites W2026545858 @default.
• W2890500897 cites W2027221283 @default.
• W2890500897 cites W2027419908 @default.
• W2890500897 cites W2029162308 @default.
• W2890500897 cites W2033357754 @default.
• W2890500897 cites W2039582673 @default.
• W2890500897 cites W2040578994 @default.
• W2890500897 cites W2043897455 @default.
• W2890500897 cites W2044921286 @default.
• W2890500897 cites W2049172199 @default.
• W2890500897 cites W2064332148 @default.
• W2890500897 cites W2067381623 @default.
• W2890500897 cites W2072307990 @default.
• W2890500897 cites W2078872808 @default.
• W2890500897 cites W2085030105 @default.
• W2890500897 cites W2117871365 @default.
• W2890500897 cites W2120714892 @default.
• W2890500897 cites W2121087546 @default.
• W2890500897 cites W2142613692 @default.
• W2890500897 cites W2157636363 @default.
• W2890500897 cites W2161221966 @default.
• W2890500897 cites W2166273322 @default.
• W2890500897 cites W2302799799 @default.
• W2890500897 cites W2557351719 @default.
• W2890500897 cites W2587769401 @default.
• W2890500897 cites W2590626967 @default.
• W2890500897 cites W2610546084 @default.
• W2890500897 cites W2761055723 @default.
• W2890500897 cites W2779868152 @default.
• W2890500897 cites W2793883488 @default.
• W2890500897 doi "https://doi.org/10.1371/journal.pone.0203955" @default.
• W2890500897 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6147434" @default.
• W2890500897 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30235277" @default.
• W2890500897 hasPublicationYear "2018" @default.
• W2890500897 type Work @default.
• W2890500897 sameAs 2890500897 @default.
• W2890500897 citedByCount "6" @default.
• W2890500897 countsByYear W28905008972019 @default.
• W2890500897 countsByYear W28905008972020 @default.
• W2890500897 countsByYear W28905008972023 @default.
• W2890500897 crossrefType "journal-article" @default.
• W2890500897 hasAuthorship W2890500897A5013226401 @default.
• W2890500897 hasAuthorship W2890500897A5027950965 @default.
• W2890500897 hasAuthorship W2890500897A5028075577 @default.
• W2890500897 hasAuthorship W2890500897A5032976426 @default.
• W2890500897 hasAuthorship W2890500897A5039568106 @default.
• W2890500897 hasAuthorship W2890500897A5047048178 @default.
• W2890500897 hasAuthorship W2890500897A5054182018 @default.
• W2890500897 hasAuthorship W2890500897A5054330291 @default.
• W2890500897 hasAuthorship W2890500897A5079028675 @default.
• W2890500897 hasBestOaLocation W28905008971 @default.
• W2890500897 hasConcept C126322002 @default.
• W2890500897 hasConcept C134018914 @default.
• W2890500897 hasConcept C178790620 @default.
• W2890500897 hasConcept C185592680 @default.
• W2890500897 hasConcept C2776175824 @default.
• W2890500897 hasConcept C2776179834 @default.
• W2890500897 hasConcept C2776384668 @default.
• W2890500897 hasConcept C2776557347 @default.
• W2890500897 hasConcept C2777799968 @default.
• W2890500897 hasConcept C2778917026 @default.
• W2890500897 hasConcept C2779668550 @default.
• W2890500897 hasConcept C2781217586 @default.
• W2890500897 hasConcept C2910876585 @default.
• W2890500897 hasConcept C3018697912 @default.
• W2890500897 hasConcept C519581460 @default.
• W2890500897 hasConcept C55493867 @default.
• W2890500897 hasConcept C71924100 @default.
• W2890500897 hasConcept C89560881 @default.

• next