Matches in SemOpenAlex for { <https://semopenalex.org/work/W2890504600> ?p ?o ?g. }
- W2890504600 endingPage "3018" @default.
- W2890504600 startingPage "3008" @default.
- W2890504600 abstract "mTOR pathway inhibitors such as rapalogs represent a promising tool to induce functional memory CD8 T cells. In our study, we investigated the combination of temsirolimus with anticancer vaccines. Using various designs of cancer vaccines (short and long peptides or the B subunit of Shiga toxin as an antigen delivery vector) and tumor models (melanoma, lung and colon cancer), we showed that the administration of temsirolimus efficiently decreased tumor growth and enhanced tumor‐specific CD8 T‐cell responses induced by vaccination. Furthermore, tumor‐specific CD8 T cells induced by the bi‐therapy (vaccine + temsirolimus) exhibit phenotypic characteristics of central memory (CD127 + CD62L + ) CD8 T cells compared to vaccination alone. We demonstrated that regulatory CD4 T cells (T regs ) expansion in vivo limits the efficacy of the bi‐therapy by altering the antitumor CD8 T‐cell responses. Finally, the use of a small molecule CCR4 antagonist to prevent T regs induction considerably improved the efficacy of the bi‐therapy by enhancing CD8 T cells‐mediated antitumor immunity. Taken together, our study highlights the potential interest of combining cancer vaccines with drugs that promote memory CD8 T cells and inhibit T regs ." @default.
- W2890504600 created "2018-09-27" @default.
- W2890504600 creator A5013413507 @default.
- W2890504600 creator A5013984891 @default.
- W2890504600 creator A5018415934 @default.
- W2890504600 creator A5033031556 @default.
- W2890504600 creator A5035492096 @default.
- W2890504600 creator A5060518732 @default.
- W2890504600 creator A5075650598 @default.
- W2890504600 creator A5080931242 @default.
- W2890504600 creator A5081117216 @default.
- W2890504600 creator A5086147416 @default.
- W2890504600 date "2018-10-01" @default.
- W2890504600 modified "2023-10-09" @default.
- W2890504600 title "Rapalog combined with CCR4 antagonist improves anticancer vaccines efficacy" @default.
- W2890504600 cites W1591397815 @default.
- W2890504600 cites W1627033116 @default.
- W2890504600 cites W1922412259 @default.
- W2890504600 cites W1979214273 @default.
- W2890504600 cites W1980296375 @default.
- W2890504600 cites W1982704558 @default.
- W2890504600 cites W1994993231 @default.
- W2890504600 cites W2038670965 @default.
- W2890504600 cites W2056721231 @default.
- W2890504600 cites W2059689009 @default.
- W2890504600 cites W2060207478 @default.
- W2890504600 cites W2063888187 @default.
- W2890504600 cites W2064876347 @default.
- W2890504600 cites W2074546881 @default.
- W2890504600 cites W2081061928 @default.
- W2890504600 cites W2096477330 @default.
- W2890504600 cites W2100714842 @default.
- W2890504600 cites W2104156406 @default.
- W2890504600 cites W2104454069 @default.
- W2890504600 cites W2104801234 @default.
- W2890504600 cites W2110714188 @default.
- W2890504600 cites W2115686439 @default.
- W2890504600 cites W2117636996 @default.
- W2890504600 cites W2118677643 @default.
- W2890504600 cites W2121007697 @default.
- W2890504600 cites W2127063807 @default.
- W2890504600 cites W2131536528 @default.
- W2890504600 cites W2137158234 @default.
- W2890504600 cites W2138466297 @default.
- W2890504600 cites W2144323242 @default.
- W2890504600 cites W2147652122 @default.
- W2890504600 cites W2149010238 @default.
- W2890504600 cites W2153867442 @default.
- W2890504600 cites W2155759076 @default.
- W2890504600 cites W2158123524 @default.
- W2890504600 cites W2167188058 @default.
- W2890504600 cites W2172901603 @default.
- W2890504600 cites W2252585899 @default.
- W2890504600 cites W2295202170 @default.
- W2890504600 cites W2326223130 @default.
- W2890504600 cites W2334692764 @default.
- W2890504600 cites W2339317612 @default.
- W2890504600 cites W2340563390 @default.
- W2890504600 cites W2398103487 @default.
- W2890504600 cites W2410302390 @default.
- W2890504600 cites W2513737916 @default.
- W2890504600 cites W2617387200 @default.
- W2890504600 cites W2743388258 @default.
- W2890504600 cites W4294214970 @default.
- W2890504600 doi "https://doi.org/10.1002/ijc.31842" @default.
- W2890504600 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30183073" @default.
- W2890504600 hasPublicationYear "2018" @default.
- W2890504600 type Work @default.
- W2890504600 sameAs 2890504600 @default.
- W2890504600 citedByCount "15" @default.
- W2890504600 countsByYear W28905046002019 @default.
- W2890504600 countsByYear W28905046002020 @default.
- W2890504600 countsByYear W28905046002021 @default.
- W2890504600 countsByYear W28905046002022 @default.
- W2890504600 crossrefType "journal-article" @default.
- W2890504600 hasAuthorship W2890504600A5013413507 @default.
- W2890504600 hasAuthorship W2890504600A5013984891 @default.
- W2890504600 hasAuthorship W2890504600A5018415934 @default.
- W2890504600 hasAuthorship W2890504600A5033031556 @default.
- W2890504600 hasAuthorship W2890504600A5035492096 @default.
- W2890504600 hasAuthorship W2890504600A5060518732 @default.
- W2890504600 hasAuthorship W2890504600A5075650598 @default.
- W2890504600 hasAuthorship W2890504600A5080931242 @default.
- W2890504600 hasAuthorship W2890504600A5081117216 @default.
- W2890504600 hasAuthorship W2890504600A5086147416 @default.
- W2890504600 hasBestOaLocation W28905046001 @default.
- W2890504600 hasConcept C147483822 @default.
- W2890504600 hasConcept C154317977 @default.
- W2890504600 hasConcept C167672396 @default.
- W2890504600 hasConcept C183713625 @default.
- W2890504600 hasConcept C202751555 @default.
- W2890504600 hasConcept C203014093 @default.
- W2890504600 hasConcept C2776820818 @default.
- W2890504600 hasConcept C502942594 @default.
- W2890504600 hasConcept C55493867 @default.
- W2890504600 hasConcept C62478195 @default.
- W2890504600 hasConcept C71924100 @default.
- W2890504600 hasConcept C86554907 @default.