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- W2890512162 abstract "miRs have been suggested to mediate pleiotropic effects of statins, including improvement of endothelial function as well as anti-inflammatory and immunomodulatory activities. miRs have been suggested to be implicated in the variations in the statin response. This role might be, at least in part, mediated via interaction of miRs with cytochrome P450 isoenzymes that are involved in statin metabolism. Upregulation of selected miRs by statins might enhance plaque stability by modulating multiple pathways, namely, repression of angiogenesis, atherosclerosis-related cell proliferation, monocyte migration, platelet adhesion, and the coagulation cascade. Cardiovascular disease (CVD) is a major cause of death globally. Addressing cardiovascular risk factors, particularly dyslipidemia, represents the most robust clinical strategy towards reducing the CVD burden. Statins inhibit 3-hydroxy-3-methylglutaryl-CoA (HMG-CoA) reductase and represent the main therapeutic approach for lowering cholesterol and reducing plaque formation/rupture. The protective effects of statins extend beyond lowering cholesterol. MicroRNAs (miRNAs or miRs), small noncoding regulatory RNAs, likely mediate the positive pleiotropic effects of statins via modulation of lipid metabolism, enhancement of endothelial function, inhibition of inflammation, improvement of plaque stability, and immune regulation. miRNAs are implicated in statin-related interindividual variations in therapeutic response, directly via HMG-CoA reductase, or indirectly through targeting cytochrome P450 3A (CYP3A) functionality and proprotein convertase subtilisin/kexin type9 (PCSK9) biology. Cardiovascular disease (CVD) is a major cause of death globally. Addressing cardiovascular risk factors, particularly dyslipidemia, represents the most robust clinical strategy towards reducing the CVD burden. Statins inhibit 3-hydroxy-3-methylglutaryl-CoA (HMG-CoA) reductase and represent the main therapeutic approach for lowering cholesterol and reducing plaque formation/rupture. The protective effects of statins extend beyond lowering cholesterol. MicroRNAs (miRNAs or miRs), small noncoding regulatory RNAs, likely mediate the positive pleiotropic effects of statins via modulation of lipid metabolism, enhancement of endothelial function, inhibition of inflammation, improvement of plaque stability, and immune regulation. miRNAs are implicated in statin-related interindividual variations in therapeutic response, directly via HMG-CoA reductase, or indirectly through targeting cytochrome P450 3A (CYP3A) functionality and proprotein convertase subtilisin/kexin type9 (PCSK9) biology. chemically engineered oligonucleotides that prevent other molecules from binding to a particular site on an mRNA molecule and therefore silence the endogenous microRNA. They are also known as anti-miRs or blockmirs. genes produce enzymes that are involved in the synthesis and metabolism of molecules and chemicals within cells. Cytochrome P450 enzymes play a role in the synthesis of steroid hormones, cholesterol and other fatty acids, and bile acids. a metabolic intermediary in the mevalonate and ketogenesis pathways, key pathways for the metabolism of branched-chain amino acids. a group of enzymes responsible for collagen and other protein degradation in the extracellular matrix. The degradation of collagen is very important in development, morphogenesis, tissue remodeling, and repair. small noncoding RNA molecules that are not translated into protein. Approximately 22 nucleotides in length, their function is to silence RNA and in post-transcriptional regulation of gene expression. miRNAs (also called miRs) are evolutionarily conserved and are abundant in mammalian cells. an enzyme encoded by the PCSK9 gene. PCSK9, expressed in many tissues and cell types, binds to the low-density lipoprotein receptor (LDLR), and transports fat molecules, including cholesterol, in extracellular fluid. PCSK9 is important in lipoprotein homeostasis, and drugs that block PCSK9 can lower LDL particle concentrations. HMG-coA reductase inhibitors, a class of lipid-lowering agents. Statins block the conversion of HMG-CoA to mevalonic acid and thus decrease the biosynthesis of cholesterol and decrease the concentration of low-density lipoprotein cholesterol (LDL-C) in the circulation. Examples of the statin drugs include atorvastatin, fluvastatin, pravastatin, rosuvastatin. a pathological condition associated with metabolic dysfunction in which there is accumulation of lipid in hepatocytes. a chemical substance found within an organism that is not naturally produced by the organism or expected to be present in the organism. This can include drugs, pollutants, and some food additives." @default.
- W2890512162 created "2018-09-27" @default.
- W2890512162 creator A5022387451 @default.
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- W2890512162 date "2018-11-01" @default.
- W2890512162 modified "2023-09-29" @default.
- W2890512162 title "MicroRNAs: Novel Molecular Targets and Response Modulators of Statin Therapy" @default.
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