Matches in SemOpenAlex for { <https://semopenalex.org/work/W2890520596> ?p ?o ?g. }
Showing items 1 to 77 of
77
with 100 items per page.
- W2890520596 abstract "Silver nanoparticles (AgNPs) are widely used in consumer products and the medical field for their antimicrobial properties. Some studies reported toxic effects of AgNPs but cellular uptake of AgNPs and AgNP-induced inflammation pathways are still not fully understood. Mast cells and macrophages are essential players of innate and adaptive immune response against invading foreign materials. Mast cells and macrophages express various receptors to help in recognition and clearance of invading pathogens and foreign molecules. Scavenger receptors such as scavenger receptor B1 (SR-B1) expressed by different types of cells, play an important role in biomolecule transport such as cholesterol transport inside cells. In addition, SR-B1 has been reported to be a multi-ligand receptor and can interact with negatively charged molecules leading to uptake and activation of signaling pathways. The aim of this study was to investigate role of SR-B1 and influence of physicochemical properties of AgNPs on mast cell and macrophage AgNPs uptake and subsequent inflammatory responses. We assessed mast cell and macrophage uptake of different types of AgNPs that differ in shape, size, charge, coating, and suspension media. The physicochemical properties were found to influence levels of AgNPs uptake by mast cell and macrophage. In addition, inflammatory responses of mast cells and macrophages were found to be influenced by the physicochemical properties of AgNPs. Furthermore, SR-B1 was found to mediate AgNPs cellular uptake and influence the inflammatory response following AgNPs exposure. These findings have implications in understanding mechanisms of AgNPs toxicity. Further, these findings suggest that modifications of the physicochemical properties can help in targeting or avoiding specific receptors. Therefore, safer AgNPs can be produced and used in biomedical applications." @default.
- W2890520596 created "2018-09-27" @default.
- W2890520596 creator A5085594800 @default.
- W2890520596 date "2018-04-09" @default.
- W2890520596 modified "2023-09-27" @default.
- W2890520596 title "INFLUENCE OF PHYSICOCHEMICAL PROPERTIES OF SILVER NANOPARTICLES ON MAST CELL AND MACROPHAGE UPTAKE AND ACTVATION: ROLE OF SCAVENGER RECEPTOR B1" @default.
- W2890520596 hasPublicationYear "2018" @default.
- W2890520596 type Work @default.
- W2890520596 sameAs 2890520596 @default.
- W2890520596 citedByCount "0" @default.
- W2890520596 crossrefType "journal-article" @default.
- W2890520596 hasAuthorship W2890520596A5085594800 @default.
- W2890520596 hasConcept C12554922 @default.
- W2890520596 hasConcept C155672457 @default.
- W2890520596 hasConcept C170493617 @default.
- W2890520596 hasConcept C171250308 @default.
- W2890520596 hasConcept C185592680 @default.
- W2890520596 hasConcept C192562407 @default.
- W2890520596 hasConcept C202751555 @default.
- W2890520596 hasConcept C203014093 @default.
- W2890520596 hasConcept C2776914184 @default.
- W2890520596 hasConcept C2778163477 @default.
- W2890520596 hasConcept C2779244956 @default.
- W2890520596 hasConcept C2779726688 @default.
- W2890520596 hasConcept C2780072125 @default.
- W2890520596 hasConcept C31499863 @default.
- W2890520596 hasConcept C41443022 @default.
- W2890520596 hasConcept C55493867 @default.
- W2890520596 hasConcept C86803240 @default.
- W2890520596 hasConcept C8891405 @default.
- W2890520596 hasConcept C95444343 @default.
- W2890520596 hasConceptScore W2890520596C12554922 @default.
- W2890520596 hasConceptScore W2890520596C155672457 @default.
- W2890520596 hasConceptScore W2890520596C170493617 @default.
- W2890520596 hasConceptScore W2890520596C171250308 @default.
- W2890520596 hasConceptScore W2890520596C185592680 @default.
- W2890520596 hasConceptScore W2890520596C192562407 @default.
- W2890520596 hasConceptScore W2890520596C202751555 @default.
- W2890520596 hasConceptScore W2890520596C203014093 @default.
- W2890520596 hasConceptScore W2890520596C2776914184 @default.
- W2890520596 hasConceptScore W2890520596C2778163477 @default.
- W2890520596 hasConceptScore W2890520596C2779244956 @default.
- W2890520596 hasConceptScore W2890520596C2779726688 @default.
- W2890520596 hasConceptScore W2890520596C2780072125 @default.
- W2890520596 hasConceptScore W2890520596C31499863 @default.
- W2890520596 hasConceptScore W2890520596C41443022 @default.
- W2890520596 hasConceptScore W2890520596C55493867 @default.
- W2890520596 hasConceptScore W2890520596C86803240 @default.
- W2890520596 hasConceptScore W2890520596C8891405 @default.
- W2890520596 hasConceptScore W2890520596C95444343 @default.
- W2890520596 hasLocation W28905205961 @default.
- W2890520596 hasOpenAccess W2890520596 @default.
- W2890520596 hasPrimaryLocation W28905205961 @default.
- W2890520596 hasRelatedWork W1974203143 @default.
- W2890520596 hasRelatedWork W1987386891 @default.
- W2890520596 hasRelatedWork W1997352644 @default.
- W2890520596 hasRelatedWork W2100575982 @default.
- W2890520596 hasRelatedWork W2123387939 @default.
- W2890520596 hasRelatedWork W2330908467 @default.
- W2890520596 hasRelatedWork W2521880295 @default.
- W2890520596 hasRelatedWork W2558842555 @default.
- W2890520596 hasRelatedWork W2791113304 @default.
- W2890520596 hasRelatedWork W2791811663 @default.
- W2890520596 hasRelatedWork W2913761071 @default.
- W2890520596 hasRelatedWork W2971851748 @default.
- W2890520596 hasRelatedWork W2989560674 @default.
- W2890520596 hasRelatedWork W3033589985 @default.
- W2890520596 hasRelatedWork W3121510456 @default.
- W2890520596 hasRelatedWork W3131401009 @default.
- W2890520596 hasRelatedWork W3165606507 @default.
- W2890520596 hasRelatedWork W3193861286 @default.
- W2890520596 hasRelatedWork W573769875 @default.
- W2890520596 hasRelatedWork W2988121145 @default.
- W2890520596 isParatext "false" @default.
- W2890520596 isRetracted "false" @default.
- W2890520596 magId "2890520596" @default.
- W2890520596 workType "article" @default.