Matches in SemOpenAlex for { <https://semopenalex.org/work/W2890531257> ?p ?o ?g. }
Showing items 1 to 92 of
92
with 100 items per page.
- W2890531257 endingPage "140" @default.
- W2890531257 startingPage "132" @default.
- W2890531257 abstract "To evaluate OS and toxicity after definitive radiation with concurrent cetuximab (CTX-RT) compared to radiation with concurrent cytotoxic chemotherapy (CRT) in older HNSCC patients via the SEER-Medicare linked database. We used the SEER-Medicare linked database to evaluate OS in HNSCC patients (Oropharynx, Larynx, Hypopharynx, Nasopharynx) diagnosed over 2005–2011, following FDA approval of cetuximab in combination with radiation therapy (RT) in March 2006. 2135 beneficiaries were identified. Median age was 73 (66–104) years. Primary was oropharynx (61%), hypopharynx (15%), nasopharynx (5%), and larynx (19%). CRT was platinum based in 82% of patients. CTX-RT was associated with worse OS compared to CRT (P < 0.005), and similar OS to RT (P = 0.21); 5-year OS was 46% for CRT, 35% for CTX-RT, 32% for RT. Patients were more likely to receive CTX-RT vs. CRT if they had oropharyngeal vs nasopharyngeal primary, Charlson comorbidity index 2 vs 0, older age at diagnosis. Multivariable Cox regression showed that CTX-RT was associated with a higher risk of death compared to CRT (hazard ratio = 1.23, 1.07–1.42; p = 0.005), after stratifying by stage and primary site, and adjusting for gender, race, age, income, Charlson comorbidity index, marital status, hospital type, and year of diagnosis. There were no differences in dysphagia, gastrostomy tube placement, pneumonia, and weight loss over the first 12 months after diagnosis. Despite the limitations to comparative effectiveness evaluation in population-based registries, our data suggest that cytotoxic chemotherapy should be used with RT for eligible older HNSCC patients." @default.
- W2890531257 created "2018-09-27" @default.
- W2890531257 creator A5012068082 @default.
- W2890531257 creator A5032809504 @default.
- W2890531257 creator A5079940663 @default.
- W2890531257 creator A5087818889 @default.
- W2890531257 date "2018-11-01" @default.
- W2890531257 modified "2023-10-17" @default.
- W2890531257 title "Definitive radiation with concurrent cetuximab vs. radiation with or without concurrent cytotoxic chemotherapy in older patients with squamous cell carcinoma of the head and neck: Analysis of the SEER-medicare linked database" @default.
- W2890531257 cites W1554549663 @default.
- W2890531257 cites W1974227785 @default.
- W2890531257 cites W2089257078 @default.
- W2890531257 cites W2114041936 @default.
- W2890531257 cites W2125919881 @default.
- W2890531257 cites W2146955099 @default.
- W2890531257 cites W2151730005 @default.
- W2890531257 cites W2152609192 @default.
- W2890531257 cites W2155384808 @default.
- W2890531257 cites W2170971614 @default.
- W2890531257 cites W2293600379 @default.
- W2890531257 cites W2468155864 @default.
- W2890531257 cites W2512495455 @default.
- W2890531257 cites W2564548469 @default.
- W2890531257 doi "https://doi.org/10.1016/j.oraloncology.2018.09.023" @default.
- W2890531257 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30409293" @default.
- W2890531257 hasPublicationYear "2018" @default.
- W2890531257 type Work @default.
- W2890531257 sameAs 2890531257 @default.
- W2890531257 citedByCount "19" @default.
- W2890531257 countsByYear W28905312572019 @default.
- W2890531257 countsByYear W28905312572020 @default.
- W2890531257 countsByYear W28905312572021 @default.
- W2890531257 countsByYear W28905312572022 @default.
- W2890531257 countsByYear W28905312572023 @default.
- W2890531257 crossrefType "journal-article" @default.
- W2890531257 hasAuthorship W2890531257A5012068082 @default.
- W2890531257 hasAuthorship W2890531257A5032809504 @default.
- W2890531257 hasAuthorship W2890531257A5079940663 @default.
- W2890531257 hasAuthorship W2890531257A5087818889 @default.
- W2890531257 hasConcept C121608353 @default.
- W2890531257 hasConcept C126322002 @default.
- W2890531257 hasConcept C141071460 @default.
- W2890531257 hasConcept C143998085 @default.
- W2890531257 hasConcept C207103383 @default.
- W2890531257 hasConcept C2776530083 @default.
- W2890531257 hasConcept C2776833033 @default.
- W2890531257 hasConcept C2779998722 @default.
- W2890531257 hasConcept C2780474809 @default.
- W2890531257 hasConcept C2908647359 @default.
- W2890531257 hasConcept C44249647 @default.
- W2890531257 hasConcept C50382708 @default.
- W2890531257 hasConcept C509974204 @default.
- W2890531257 hasConcept C526805850 @default.
- W2890531257 hasConcept C71924100 @default.
- W2890531257 hasConcept C99454951 @default.
- W2890531257 hasConceptScore W2890531257C121608353 @default.
- W2890531257 hasConceptScore W2890531257C126322002 @default.
- W2890531257 hasConceptScore W2890531257C141071460 @default.
- W2890531257 hasConceptScore W2890531257C143998085 @default.
- W2890531257 hasConceptScore W2890531257C207103383 @default.
- W2890531257 hasConceptScore W2890531257C2776530083 @default.
- W2890531257 hasConceptScore W2890531257C2776833033 @default.
- W2890531257 hasConceptScore W2890531257C2779998722 @default.
- W2890531257 hasConceptScore W2890531257C2780474809 @default.
- W2890531257 hasConceptScore W2890531257C2908647359 @default.
- W2890531257 hasConceptScore W2890531257C44249647 @default.
- W2890531257 hasConceptScore W2890531257C50382708 @default.
- W2890531257 hasConceptScore W2890531257C509974204 @default.
- W2890531257 hasConceptScore W2890531257C526805850 @default.
- W2890531257 hasConceptScore W2890531257C71924100 @default.
- W2890531257 hasConceptScore W2890531257C99454951 @default.
- W2890531257 hasLocation W28905312571 @default.
- W2890531257 hasLocation W28905312572 @default.
- W2890531257 hasOpenAccess W2890531257 @default.
- W2890531257 hasPrimaryLocation W28905312571 @default.
- W2890531257 hasRelatedWork W1956415942 @default.
- W2890531257 hasRelatedWork W1996158748 @default.
- W2890531257 hasRelatedWork W2047962734 @default.
- W2890531257 hasRelatedWork W2062707457 @default.
- W2890531257 hasRelatedWork W2077763859 @default.
- W2890531257 hasRelatedWork W2081836551 @default.
- W2890531257 hasRelatedWork W2110125130 @default.
- W2890531257 hasRelatedWork W3012537123 @default.
- W2890531257 hasRelatedWork W3093167374 @default.
- W2890531257 hasRelatedWork W3154194420 @default.
- W2890531257 hasVolume "86" @default.
- W2890531257 isParatext "false" @default.
- W2890531257 isRetracted "false" @default.
- W2890531257 magId "2890531257" @default.
- W2890531257 workType "article" @default.