FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W289053284> ?p ?o ?g. }

• W289053284 abstract "Abstract : Doxorubicin (DOXO), cisplatin (CDDP) and paclitaxel (PAC) are most commonly used chemotherapeutic drugs for p53 mutant TNBC; however, the treatments eventually fail due to acquired drug resistance and toxicity. Here we report on the reconstitution of p53 in a p53-independent manner via p73 as an exciting possibility for improving cancer therapy. -TEA, an analog of vitamin E, which exhibits potent anticancer actions in vitro and in vivo, cooperates with DOXO or CDDP to enhance anticancer actions detected by apoptosis in p53 mutant TNBC cell lines. The combination treatments of -TEA with DOXO or CDDP enhanced p73 protein expression, enhanced levels of death receptors-5 (DR5), CD95/APO-1 (Fas), Bax and Noxa proteins, and reduced antiapoptotic Bcl-2 protein levels, all of which are p53 regulated genes. The combination treatments induced enhanced levels of phospho-c-Ab1 and -JNK, as well as induced Yap nuclear translocation, which are upstream events for p73 activation. Data demonstrated that -TEA cooperates with chemotherapeutic drugs (DOXO and CDDP) to induce apoptosis via targeting p53 downstream apoptotic mediators in a p73-dependent manner. Furthermore, in vivo data show that -TEA inhibits DOXO-induced lung metastasis. Taken together, our in vitro and in vivo data suggest that the combination of -TEA plus clinically relevant chemotherapeutic drugs enhances anticancer actions in p53 mutant TNBC cells via activation of p73." @default.
• W289053284 created "2016-06-24" @default.
• W289053284 creator A5048696544 @default.
• W289053284 date "2011-09-01" @default.
• W289053284 modified "2023-09-23" @default.
• W289053284 title "Strategy for Restoring Drug Sensitivity to Triple-Negative Breast Cancer" @default.
• W289053284 cites W1524638010 @default.
• W289053284 cites W1675096266 @default.
• W289053284 cites W1965727325 @default.
• W289053284 cites W1966292443 @default.
• W289053284 cites W1966380992 @default.
• W289053284 cites W1976776826 @default.
• W289053284 cites W1981353415 @default.
• W289053284 cites W1987783969 @default.
• W289053284 cites W1989444090 @default.
• W289053284 cites W1999539203 @default.
• W289053284 cites W2001781880 @default.
• W289053284 cites W2003044806 @default.
• W289053284 cites W2004445242 @default.
• W289053284 cites W2011818472 @default.
• W289053284 cites W2016965938 @default.
• W289053284 cites W2017052599 @default.
• W289053284 cites W2020696262 @default.
• W289053284 cites W2020994403 @default.
• W289053284 cites W2022423243 @default.
• W289053284 cites W2038441458 @default.
• W289053284 cites W2041134283 @default.
• W289053284 cites W2061799336 @default.
• W289053284 cites W2061932825 @default.
• W289053284 cites W2063981031 @default.
• W289053284 cites W2068868056 @default.
• W289053284 cites W2069924169 @default.
• W289053284 cites W2070996618 @default.
• W289053284 cites W2079943669 @default.
• W289053284 cites W2081574093 @default.
• W289053284 cites W2084708321 @default.
• W289053284 cites W2094691484 @default.
• W289053284 cites W2096772718 @default.
• W289053284 cites W2098911357 @default.
• W289053284 cites W2103616303 @default.
• W289053284 cites W2110405710 @default.
• W289053284 cites W2112881364 @default.
• W289053284 cites W2114508131 @default.
• W289053284 cites W2119751608 @default.
• W289053284 cites W2126787895 @default.
• W289053284 cites W2135918756 @default.
• W289053284 cites W2157149571 @default.
• W289053284 cites W2161579357 @default.
• W289053284 cites W2162622637 @default.
• W289053284 cites W2164712283 @default.
• W289053284 cites W2171181474 @default.
• W289053284 cites W2313048860 @default.
• W289053284 cites W2316994976 @default.
• W289053284 hasPublicationYear "2011" @default.
• W289053284 type Work @default.
• W289053284 sameAs 289053284 @default.
• W289053284 citedByCount "0" @default.
• W289053284 crossrefType "journal-article" @default.
• W289053284 hasAuthorship W289053284A5048696544 @default.
• W289053284 hasConcept C121608353 @default.
• W289053284 hasConcept C150903083 @default.
• W289053284 hasConcept C185592680 @default.
• W289053284 hasConcept C190283241 @default.
• W289053284 hasConcept C202751555 @default.
• W289053284 hasConcept C207001950 @default.
• W289053284 hasConcept C2776694085 @default.
• W289053284 hasConcept C2777292972 @default.
• W289053284 hasConcept C2778239845 @default.
• W289053284 hasConcept C2780110267 @default.
• W289053284 hasConcept C2781303535 @default.
• W289053284 hasConcept C3031857 @default.
• W289053284 hasConcept C31573885 @default.
• W289053284 hasConcept C502942594 @default.
• W289053284 hasConcept C530470458 @default.
• W289053284 hasConcept C54355233 @default.
• W289053284 hasConcept C55493867 @default.
• W289053284 hasConcept C86803240 @default.
• W289053284 hasConcept C98274493 @default.
• W289053284 hasConceptScore W289053284C121608353 @default.
• W289053284 hasConceptScore W289053284C150903083 @default.
• W289053284 hasConceptScore W289053284C185592680 @default.
• W289053284 hasConceptScore W289053284C190283241 @default.
• W289053284 hasConceptScore W289053284C202751555 @default.
• W289053284 hasConceptScore W289053284C207001950 @default.
• W289053284 hasConceptScore W289053284C2776694085 @default.
• W289053284 hasConceptScore W289053284C2777292972 @default.
• W289053284 hasConceptScore W289053284C2778239845 @default.
• W289053284 hasConceptScore W289053284C2780110267 @default.
• W289053284 hasConceptScore W289053284C2781303535 @default.
• W289053284 hasConceptScore W289053284C3031857 @default.
• W289053284 hasConceptScore W289053284C31573885 @default.
• W289053284 hasConceptScore W289053284C502942594 @default.
• W289053284 hasConceptScore W289053284C530470458 @default.
• W289053284 hasConceptScore W289053284C54355233 @default.
• W289053284 hasConceptScore W289053284C55493867 @default.
• W289053284 hasConceptScore W289053284C86803240 @default.
• W289053284 hasConceptScore W289053284C98274493 @default.
• W289053284 hasLocation W2890532841 @default.
• W289053284 hasOpenAccess W289053284 @default.
• W289053284 hasPrimaryLocation W2890532841 @default.

• next