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• W2890537493 endingPage "e1006496" @default.
• W2890537493 startingPage "e1006496" @default.
• W2890537493 abstract "Antibiotic-resistance of hospital-acquired infections is a major public health issue. The worldwide emergence and diffusion of extended-spectrum β-lactamase (ESBL)-producing Enterobacteriaceae, including Escherichia coli (ESBL-EC) and Klebsiella pneumoniae (ESBL-KP), is of particular concern. Preventing their nosocomial spread requires understanding their transmission. Using Close Proximity Interactions (CPIs), measured by wearable sensors, and weekly ESBL-EC-and ESBL-KP-carriage data, we traced their possible transmission paths among 329 patients in a 200-bed long-term care facility over 4 months. Based on phenotypically defined resistance profiles to 12 antibiotics only, new bacterial acquisitions were tracked. Extending a previously proposed statistical method, the CPI network's ability to support observed incident-colonization episodes of ESBL-EC and ESBL-KP was tested. Finally, mathematical modeling based on our findings assessed the effect of several infection-control measures. A potential infector was identified in the CPI network for 80% (16/20) of ESBL-KP acquisition episodes. The lengths of CPI paths between ESBL-KP incident cases and their potential infectors were shorter than predicted by chance (P = 0.02), indicating that CPI-network relationships were consistent with dissemination. Potential ESBL-EC infectors were identified for 54% (19/35) of the acquisitions, with longer-than-expected lengths of CPI paths. These contrasting results yielded differing impacts of infection control scenarios, with contact reduction interventions proving less effective for ESBL-EC than for ESBL-KP. These results highlight the widely variable transmission patterns among ESBL-producing Enterobacteriaceae species. CPI networks supported ESBL-KP, but not ESBL-EC spread. These outcomes could help design more specific surveillance and control strategies to prevent in-hospital Enterobacteriaceae dissemination." @default.
• W2890537493 created "2018-09-27" @default.
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• W2890537493 date "2019-05-30" @default.
• W2890537493 modified "2023-10-17" @default.
• W2890537493 title "Close proximity interactions support transmission of ESBL-K. pneumoniae but not ESBL-E. coli in healthcare settings" @default.
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• W2890537493 doi "https://doi.org/10.1371/journal.pcbi.1006496" @default.
• W2890537493 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6542504" @default.
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• W2890537493 hasPublicationYear "2019" @default.
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