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- W2890541322 abstract "When describing the profound hearing loss she suffered as a result of her treatment for multidrug-resistant tuberculosis, the noted advocate Nandita Venkatesan said: “My world fell silent around me. I am in front of people, but I am not here.” 1 Venkatesan N Hearing loss: a survivor's perspective. Presentation at the USAID Scientific Forum on Replacing the Injectable for Drug-Resistant Tuberculosis. USA, Washington, DC2018 Google Scholar In the context of India's National Tuberculosis Programme, she seems to be right: 8 years after she was clinically diagnosed, first with abdominal tuberculosis and then multidrug-resistant tuberculosis, Venkatesan was declared to be a treatment success. This outcome is a rarity in multidrug-resistant tuberculosis, for which global success rates are roughly 50%. 2 WHO Global tuberculosis report 2017. World Health Organization, Geneva2017 Google Scholar Yet the bacteriological outcomes by which victories are measured in the battle to end tuberculosis give scant attention to the long-term consequences of treatment, including permanent hearing loss and its attendant unemployment, social isolation, and depression. Treatment correlates of successful outcomes in pulmonary multidrug-resistant tuberculosis: an individual patient data meta-analysisAlthough inferences are limited by the observational nature of these data, treatment outcomes were significantly better with use of linezolid, later generation fluoroquinolones, bedaquiline, clofazimine, and carbapenems for treatment of multidrug-resistant tuberculosis. These findings emphasise the need for trials to ascertain the optimal combination and duration of these drugs for treatment of this condition. Full-Text PDF" @default.
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- W2890541322 date "2018-09-01" @default.
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- W2890541322 title "Reducing harm in the treatment of multidrug-resistant tuberculosis" @default.
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- W2890541322 doi "https://doi.org/10.1016/s0140-6736(18)31670-2" @default.
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