FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2890555615> ?p ?o ?g. }

• W2890555615 endingPage "189" @default.
• W2890555615 startingPage "185" @default.
• W2890555615 abstract "Objective To estimate the relationship of initial pharmacotherapy with methadone or morphine and length of stay (LOS) in infants with neonatal abstinence syndrome (NAS) admitted to the neonatal intensive care unit (NICU). Study design From the Pediatrix Clinical Data Warehouse database, we identified all infants born at ≥36 weeks of gestation between 2011 and 2015 who were diagnosed with NAS (International Classification of Diseases, Ninth Revision code 779.5) and treated with methadone or morphine in the first 7 days of life. We used multivariable Cox proportional hazards regression analysis to quantify the association between initial treatment and LOS after adjusting for maternal age, maternal race/ethnicity, maternal drug use, maternal smoking, gestational age, small for gestational age status, inborn status, and discharge year. Results We identified a total of 7667 eligible infants, including 1187 treated with methadone (15%) and 6480 treated with morphine (85%). Birth weight, gestational age, and sex were similar in the 2 groups. Methadone treatment was associated with a 22% shorter median LOS (18 days [IQR, 11-30 days] vs 23 days [IQR, 16-33]; P < .001) and a 19% shorter median NICU stay (17 days [IQR, 10-29 days] vs 21 days [IQR, 14-36 days]; P < .001). After adjustment, methadone was associated with a shorter LOS (hazard ratio for discharge, 1.24; 95% CI, 1.11-1.37; P < .001) Conclusion Among infants born at ≥36 weeks of gestation with NAS, initial methadone treatment was associated with a shorter LOS compared with morphine treatment. Future prospective comparative effectiveness trials to treat infants with NAS are needed to verify this observation. To estimate the relationship of initial pharmacotherapy with methadone or morphine and length of stay (LOS) in infants with neonatal abstinence syndrome (NAS) admitted to the neonatal intensive care unit (NICU). From the Pediatrix Clinical Data Warehouse database, we identified all infants born at ≥36 weeks of gestation between 2011 and 2015 who were diagnosed with NAS (International Classification of Diseases, Ninth Revision code 779.5) and treated with methadone or morphine in the first 7 days of life. We used multivariable Cox proportional hazards regression analysis to quantify the association between initial treatment and LOS after adjusting for maternal age, maternal race/ethnicity, maternal drug use, maternal smoking, gestational age, small for gestational age status, inborn status, and discharge year. We identified a total of 7667 eligible infants, including 1187 treated with methadone (15%) and 6480 treated with morphine (85%). Birth weight, gestational age, and sex were similar in the 2 groups. Methadone treatment was associated with a 22% shorter median LOS (18 days [IQR, 11-30 days] vs 23 days [IQR, 16-33]; P < .001) and a 19% shorter median NICU stay (17 days [IQR, 10-29 days] vs 21 days [IQR, 14-36 days]; P < .001). After adjustment, methadone was associated with a shorter LOS (hazard ratio for discharge, 1.24; 95% CI, 1.11-1.37; P < .001) Among infants born at ≥36 weeks of gestation with NAS, initial methadone treatment was associated with a shorter LOS compared with morphine treatment. Future prospective comparative effectiveness trials to treat infants with NAS are needed to verify this observation." @default.
• W2890555615 created "2018-09-27" @default.
• W2890555615 creator A5006401725 @default.
• W2890555615 creator A5008227471 @default.
• W2890555615 creator A5008852386 @default.
• W2890555615 creator A5017306415 @default.
• W2890555615 creator A5067695269 @default.
• W2890555615 creator A5076556014 @default.
• W2890555615 creator A5081987147 @default.
• W2890555615 date "2018-12-01" @default.
• W2890555615 modified "2023-09-25" @default.
• W2890555615 title "Morphine vs Methadone Treatment for Infants with Neonatal Abstinence Syndrome" @default.
• W2890555615 cites W1965307957 @default.
• W2890555615 cites W1991488924 @default.
• W2890555615 cites W2005498024 @default.
• W2890555615 cites W2021256567 @default.
• W2890555615 cites W2025988777 @default.
• W2890555615 cites W2029540523 @default.
• W2890555615 cites W2040113464 @default.
• W2890555615 cites W2047822006 @default.
• W2890555615 cites W2048870090 @default.
• W2890555615 cites W2090458405 @default.
• W2890555615 cites W2117713721 @default.
• W2890555615 cites W2150910069 @default.
• W2890555615 cites W2153086151 @default.
• W2890555615 cites W2155957464 @default.
• W2890555615 cites W2341129469 @default.
• W2890555615 cites W2404237987 @default.
• W2890555615 cites W2765476035 @default.
• W2890555615 cites W2781572752 @default.
• W2890555615 cites W2791800224 @default.
• W2890555615 doi "https://doi.org/10.1016/j.jpeds.2018.07.061" @default.
• W2890555615 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30220442" @default.
• W2890555615 hasPublicationYear "2018" @default.
• W2890555615 type Work @default.
• W2890555615 sameAs 2890555615 @default.
• W2890555615 citedByCount "18" @default.
• W2890555615 countsByYear W28905556152019 @default.
• W2890555615 countsByYear W28905556152020 @default.
• W2890555615 countsByYear W28905556152021 @default.
• W2890555615 countsByYear W28905556152022 @default.
• W2890555615 countsByYear W28905556152023 @default.
• W2890555615 crossrefType "journal-article" @default.
• W2890555615 hasAuthorship W2890555615A5006401725 @default.
• W2890555615 hasAuthorship W2890555615A5008227471 @default.
• W2890555615 hasAuthorship W2890555615A5008852386 @default.
• W2890555615 hasAuthorship W2890555615A5017306415 @default.
• W2890555615 hasAuthorship W2890555615A5067695269 @default.
• W2890555615 hasAuthorship W2890555615A5076556014 @default.
• W2890555615 hasAuthorship W2890555615A5081987147 @default.
• W2890555615 hasConcept C126322002 @default.
• W2890555615 hasConcept C131872663 @default.
• W2890555615 hasConcept C187212893 @default.
• W2890555615 hasConcept C207103383 @default.
• W2890555615 hasConcept C2777091541 @default.
• W2890555615 hasConcept C2777389121 @default.
• W2890555615 hasConcept C2778376644 @default.
• W2890555615 hasConcept C2778767360 @default.
• W2890555615 hasConcept C2779234561 @default.
• W2890555615 hasConcept C42219234 @default.
• W2890555615 hasConcept C44249647 @default.
• W2890555615 hasConcept C46973012 @default.
• W2890555615 hasConcept C54355233 @default.
• W2890555615 hasConcept C66322754 @default.
• W2890555615 hasConcept C71924100 @default.
• W2890555615 hasConcept C86803240 @default.
• W2890555615 hasConceptScore W2890555615C126322002 @default.
• W2890555615 hasConceptScore W2890555615C131872663 @default.
• W2890555615 hasConceptScore W2890555615C187212893 @default.
• W2890555615 hasConceptScore W2890555615C207103383 @default.
• W2890555615 hasConceptScore W2890555615C2777091541 @default.
• W2890555615 hasConceptScore W2890555615C2777389121 @default.
• W2890555615 hasConceptScore W2890555615C2778376644 @default.
• W2890555615 hasConceptScore W2890555615C2778767360 @default.
• W2890555615 hasConceptScore W2890555615C2779234561 @default.
• W2890555615 hasConceptScore W2890555615C42219234 @default.
• W2890555615 hasConceptScore W2890555615C44249647 @default.
• W2890555615 hasConceptScore W2890555615C46973012 @default.
• W2890555615 hasConceptScore W2890555615C54355233 @default.
• W2890555615 hasConceptScore W2890555615C66322754 @default.
• W2890555615 hasConceptScore W2890555615C71924100 @default.
• W2890555615 hasConceptScore W2890555615C86803240 @default.
• W2890555615 hasLocation W28905556151 @default.
• W2890555615 hasLocation W28905556152 @default.
• W2890555615 hasOpenAccess W2890555615 @default.
• W2890555615 hasPrimaryLocation W28905556151 @default.
• W2890555615 hasRelatedWork W1991151698 @default.
• W2890555615 hasRelatedWork W2004228627 @default.
• W2890555615 hasRelatedWork W2029126795 @default.
• W2890555615 hasRelatedWork W2127045213 @default.
• W2890555615 hasRelatedWork W2149858512 @default.
• W2890555615 hasRelatedWork W2333891256 @default.
• W2890555615 hasRelatedWork W2414057952 @default.
• W2890555615 hasRelatedWork W2555964298 @default.
• W2890555615 hasRelatedWork W2780688356 @default.
• W2890555615 hasRelatedWork W4284701438 @default.
• W2890555615 hasVolume "203" @default.
• W2890555615 isParatext "false" @default.

• next