FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2890556919> ?p ?o ?g. }

• W2890556919 endingPage "136" @default.
• W2890556919 startingPage "127" @default.
• W2890556919 abstract "Autism spectrum disorder (ASD) is a neurodevelopmental disorder whose symptoms include communication deficits, a lack of social skills, and stereotyped repetitive behaviors. We used BTBR T+ Itpr3tf/J (BTBR) mice, a model that demonstrates most of the core behavioral features of ASD, such as decreased sociability and high levels of repetitive behaviors. Currently, there is no treatment available that is able to improve most of the ASD disorder symptoms; thus, finding novel therapies is immediately required. Stat3 inhibitors are potential targets in the treatment of several immune disorders. The aim of the present study was to investigate the effects of S3I-201, a selective Stat3 inhibitor, to determine its potential mechanism in BTBR mice. In this study, we first examined the effects of S3I-201 on repetitive behavior and marble burying. We also examined the treatment of S3I-201 on Th1 (IFN-γ and T-bet), Th17 (IL-17A, RORγt, Stat3, IL-21, and IL-22), and T regulatory (Treg, Foxp3 and Helios) production in spleen CD4+ T cells. We further assessed Th1, Th17, and Treg mRNA and protein expression levels in brain tissues. S3I-201 treatment in BTBR mice significantly prevents marble burying and repetitive behavior. Furthermore, S3I-201 administration causes a considerable decrease in IFN-γ, T-bet, IL-17A, RORγt, Stat3, IL-21, and IL-22 levels, and increases in Foxp3 and Helios production CD4+ T cells in BTBR mice. Additionally, S3I-201 treatment also significantly decreases Th1 and Th17 levels, and increases Treg mRNA and protein expression levels. Therefore, these results suggest that S3I-201 could be considered as a therapeutic option for ASD." @default.
• W2890556919 created "2018-09-27" @default.
• W2890556919 creator A5007766969 @default.
• W2890556919 creator A5027744482 @default.
• W2890556919 creator A5028281135 @default.
• W2890556919 creator A5034517207 @default.
• W2890556919 creator A5036821396 @default.
• W2890556919 creator A5061296890 @default.
• W2890556919 creator A5074570955 @default.
• W2890556919 creator A5086704648 @default.
• W2890556919 date "2018-12-01" @default.
• W2890556919 modified "2023-10-07" @default.
• W2890556919 title "S3I-201, a selective Stat3 inhibitor, restores neuroimmune function through upregulation of Treg signaling in autistic BTBR T+ Itpr3tf/J mice" @default.
• W2890556919 cites W1547956541 @default.
• W2890556919 cites W1774639140 @default.
• W2890556919 cites W1964118321 @default.
• W2890556919 cites W1966784044 @default.
• W2890556919 cites W1967261754 @default.
• W2890556919 cites W1979594892 @default.
• W2890556919 cites W1996087940 @default.
• W2890556919 cites W1997275623 @default.
• W2890556919 cites W1997691550 @default.
• W2890556919 cites W1998000193 @default.
• W2890556919 cites W2000169244 @default.
• W2890556919 cites W2000961759 @default.
• W2890556919 cites W2004265420 @default.
• W2890556919 cites W2007840001 @default.
• W2890556919 cites W2014763555 @default.
• W2890556919 cites W2017918524 @default.
• W2890556919 cites W2018851253 @default.
• W2890556919 cites W2030771043 @default.
• W2890556919 cites W2031792869 @default.
• W2890556919 cites W2035339084 @default.
• W2890556919 cites W2035570187 @default.
• W2890556919 cites W2037133043 @default.
• W2890556919 cites W2052649926 @default.
• W2890556919 cites W2064957876 @default.
• W2890556919 cites W2066044455 @default.
• W2890556919 cites W2067188132 @default.
• W2890556919 cites W2070438913 @default.
• W2890556919 cites W2082109123 @default.
• W2890556919 cites W2083366087 @default.
• W2890556919 cites W2085202176 @default.
• W2890556919 cites W2085252304 @default.
• W2890556919 cites W2086264253 @default.
• W2890556919 cites W2098951793 @default.
• W2890556919 cites W2100041578 @default.
• W2890556919 cites W2109451844 @default.
• W2890556919 cites W2109664460 @default.
• W2890556919 cites W2125533507 @default.
• W2890556919 cites W2125876756 @default.
• W2890556919 cites W2127289457 @default.
• W2890556919 cites W2137386978 @default.
• W2890556919 cites W2141360737 @default.
• W2890556919 cites W2147280251 @default.
• W2890556919 cites W2153289324 @default.
• W2890556919 cites W2160083314 @default.
• W2890556919 cites W2164938398 @default.
• W2890556919 cites W2171222083 @default.
• W2890556919 cites W2177407472 @default.
• W2890556919 cites W2253802357 @default.
• W2890556919 cites W2466729104 @default.
• W2890556919 cites W2514407728 @default.
• W2890556919 cites W2515947743 @default.
• W2890556919 cites W2526262022 @default.
• W2890556919 cites W2567374205 @default.
• W2890556919 cites W2588240757 @default.
• W2890556919 cites W2605160347 @default.
• W2890556919 cites W2606873509 @default.
• W2890556919 cites W2607638135 @default.
• W2890556919 cites W2742339607 @default.
• W2890556919 cites W2763604945 @default.
• W2890556919 cites W2782161053 @default.
• W2890556919 cites W2788594750 @default.
• W2890556919 doi "https://doi.org/10.1016/j.cellsig.2018.09.006" @default.
• W2890556919 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30213685" @default.
• W2890556919 hasPublicationYear "2018" @default.
• W2890556919 type Work @default.
• W2890556919 sameAs 2890556919 @default.
• W2890556919 citedByCount "17" @default.
• W2890556919 countsByYear W28905569192019 @default.
• W2890556919 countsByYear W28905569192020 @default.
• W2890556919 countsByYear W28905569192021 @default.
• W2890556919 countsByYear W28905569192022 @default.
• W2890556919 countsByYear W28905569192023 @default.
• W2890556919 crossrefType "journal-article" @default.
• W2890556919 hasAuthorship W2890556919A5007766969 @default.
• W2890556919 hasAuthorship W2890556919A5027744482 @default.
• W2890556919 hasAuthorship W2890556919A5028281135 @default.
• W2890556919 hasAuthorship W2890556919A5034517207 @default.
• W2890556919 hasAuthorship W2890556919A5036821396 @default.
• W2890556919 hasAuthorship W2890556919A5061296890 @default.
• W2890556919 hasAuthorship W2890556919A5074570955 @default.
• W2890556919 hasAuthorship W2890556919A5086704648 @default.
• W2890556919 hasConcept C104317684 @default.
• W2890556919 hasConcept C118552586 @default.
• W2890556919 hasConcept C127561419 @default.
• W2890556919 hasConcept C15744967 @default.

• next