FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2890559906> ?p ?o ?g. }

• W2890559906 endingPage "361" @default.
• W2890559906 startingPage "339" @default.
• W2890559906 abstract "Glioblastoma multiforme (GBM), one of the most lethal Brain tumors, characterized by its high invasive nature and increased mortality rates forms a major bottleneck in transport of therapeutics across the Blood Brain Barrier (BBB). Matrix metalloproteinases (MMPs) are classified as enzymes, which are found to be up regulated in the Glioma tumor microenvironment and thus can be considered as a target for inhibition for curbing GBM. Many chemotherapeutics and techniques have been employed for inhibiting MMPs till now but all of them failed miserably and were withdrawn in clinical trials due to their inability in restricting the tumor growth or increasing the overall survival rates. Thus, the quest for finding the suitable MMP inhibitor is still on and there is a critical need for identification of novel compounds which can alter the BBB permeability, restrain tumor growth and prevent tumor recurrence. Currently, naturally derived substances are gaining widespread attention as tumor inhibitors and many studies have been reported by far highlighting their importance in restricting MMP expression thus serving as chemotherapeutics for cancer due to their minimal toxicity. These substances may serve as probable candidates for inhibiting MMP expression in GBM. However, targeting and delivering the inhibitor to its target site is an issue that needs to be overcome in order to attain maximum specificity and sustained release. The birth of nanotechnology served as a boon in delivering drugs to the most complicated areas thus paving way for Nano drug delivery. An efficient Nano carrier with ability to cross the BBB and competently kill the Glioma cells forms the prerequisite for GBM chemotherapy. Vesicular drug delivery systems are one such class of carriers, which have the capacity to release the drug at a predetermined rate at the target site thus minimizing any undesirable side effects. Exploiting vesicular systems as promising Nano drug carriers to formulate naturally derived substances, that can bypass the BBB and act as an inhibitor against MMPs in GBM is the main theme of this review." @default.
• W2890559906 created "2018-09-27" @default.
• W2890559906 creator A5017898982 @default.
• W2890559906 creator A5061699253 @default.
• W2890559906 creator A5067507459 @default.
• W2890559906 creator A5068816339 @default.
• W2890559906 date "2018-11-01" @default.
• W2890559906 modified "2023-09-23" @default.
• W2890559906 title "Vesicular systems employing natural substances as promising drug candidates for MMP inhibition in glioblastoma: A nanotechnological approach" @default.
• W2890559906 cites W1480859163 @default.
• W2890559906 cites W1493831049 @default.
• W2890559906 cites W1510308909 @default.
• W2890559906 cites W1535876276 @default.
• W2890559906 cites W1559459501 @default.
• W2890559906 cites W1588188747 @default.
• W2890559906 cites W1591653197 @default.
• W2890559906 cites W1941453499 @default.
• W2890559906 cites W1943317391 @default.
• W2890559906 cites W1965194703 @default.
• W2890559906 cites W1969370038 @default.
• W2890559906 cites W1971425380 @default.
• W2890559906 cites W1971685703 @default.
• W2890559906 cites W1972346116 @default.
• W2890559906 cites W1972840121 @default.
• W2890559906 cites W1973612882 @default.
• W2890559906 cites W1976307415 @default.
• W2890559906 cites W1981289962 @default.
• W2890559906 cites W1981576205 @default.
• W2890559906 cites W1984483611 @default.
• W2890559906 cites W1985864418 @default.
• W2890559906 cites W1987446135 @default.
• W2890559906 cites W1987448483 @default.
• W2890559906 cites W1990477020 @default.
• W2890559906 cites W1992885568 @default.
• W2890559906 cites W1994567037 @default.
• W2890559906 cites W1996719014 @default.
• W2890559906 cites W1998690636 @default.
• W2890559906 cites W1999929713 @default.
• W2890559906 cites W2002072986 @default.
• W2890559906 cites W2002771508 @default.
• W2890559906 cites W2003500892 @default.
• W2890559906 cites W2004009098 @default.
• W2890559906 cites W2005145064 @default.
• W2890559906 cites W2005334224 @default.
• W2890559906 cites W2006628284 @default.
• W2890559906 cites W2008489039 @default.
• W2890559906 cites W2009542460 @default.
• W2890559906 cites W2010750753 @default.
• W2890559906 cites W2011046820 @default.
• W2890559906 cites W2013193452 @default.
• W2890559906 cites W2015375238 @default.
• W2890559906 cites W2015809080 @default.
• W2890559906 cites W2016085763 @default.
• W2890559906 cites W2018544570 @default.
• W2890559906 cites W2019154144 @default.
• W2890559906 cites W2020913470 @default.
• W2890559906 cites W2021657783 @default.
• W2890559906 cites W2021947034 @default.
• W2890559906 cites W2025806954 @default.
• W2890559906 cites W2029963374 @default.
• W2890559906 cites W2030490037 @default.
• W2890559906 cites W2031217171 @default.
• W2890559906 cites W2034301908 @default.
• W2890559906 cites W2036161137 @default.
• W2890559906 cites W2037690301 @default.
• W2890559906 cites W2038204389 @default.
• W2890559906 cites W2039872518 @default.
• W2890559906 cites W2040301701 @default.
• W2890559906 cites W2040827479 @default.
• W2890559906 cites W2041187942 @default.
• W2890559906 cites W2042714132 @default.
• W2890559906 cites W2047021531 @default.
• W2890559906 cites W2049529196 @default.
• W2890559906 cites W2050134722 @default.
• W2890559906 cites W2050834003 @default.
• W2890559906 cites W2051720243 @default.
• W2890559906 cites W2051828991 @default.
• W2890559906 cites W2056669249 @default.
• W2890559906 cites W2057087441 @default.
• W2890559906 cites W2057340910 @default.
• W2890559906 cites W2058902820 @default.
• W2890559906 cites W2061723012 @default.
• W2890559906 cites W2061863138 @default.
• W2890559906 cites W2061896947 @default.
• W2890559906 cites W2063025997 @default.
• W2890559906 cites W2064215841 @default.
• W2890559906 cites W2066234893 @default.
• W2890559906 cites W2070373692 @default.
• W2890559906 cites W2072619059 @default.
• W2890559906 cites W2076558450 @default.
• W2890559906 cites W2081239048 @default.
• W2890559906 cites W2081246920 @default.
• W2890559906 cites W2081600938 @default.
• W2890559906 cites W2082007907 @default.
• W2890559906 cites W2082892212 @default.
• W2890559906 cites W2083785549 @default.
• W2890559906 cites W2085552822 @default.
• W2890559906 cites W2085898732 @default.

• next